Hao Yan

Molecular Design and Biomimetics
Center Director
Molecular Design and Biomimetics
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Arizona State University
University Club
University Club

Location: TEMPE

Contact Information
(480) 727-8570


  • Ph.D. Chemistry, New York University 2001
  • B.S. Chemistry, Shandong University, China 1993

Research Interests

Hao Yan's research program is highly interdisciplinary which combines chemistry, biology, physics and material science. The goal of his research group is to achieve programmed design and assembly of biologically inspired nanomaterials and to explore its applications in nanoelectronics, controlled macromolecular interactions and biosensing. Their research is focused in the following four themes:

1) Bio-Nanotechnology: Design of novel DNA nanostructures, implementation of the designed structure in the construction of patterned DNA arrays and nanomechanical devices. Develop modular methods to achieve biomimetic molecular motors.

2) Nanoelectronics: Utilize rationally designed DNA nanostructure to template nanoelectronic components such as nanoparticles or carbon nanotubes into functional nanodevices.

3) Macromolecule Structure Elucidation: Develop methods to self-assemble 2-D and 3-D protein arrays for structural determination using Electron Microscopy or X-ray Crystallography.

4) Biomolecular Imaging: Investigation of protein-DNA interactions using high resolution imaging technology such as Atomic Force Microscopy and Electron Microscopy.

Major techniques in the group include: DNA/RNA/Protein manipulation (gel electrophoresis, labeling, hybridization, PCR and footprinting, cloning), electron-beam lithography, Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Electron Microscopy (EM), Fluorescence Spectroscopy, UV-Vis, Circular Dichroism (CD) and chemical synthesis.


Hao Yan studied chemistry at Shandong University, China. He obtained his PhD in Chemistry under Professor N. C. Seeman, New York University in 2001. Following a period as an Assistant Research Professor at Duke University in the Computer Science department, he joined Arizona State University as Assistant Professor in Department of Chemistry and Biochemistry in 2004. He became a Full Professor at Arizona State University since 2008. He is currently the Milton D. Glick Distinguished Professor in Chemistry and Biochemistry and Director of the Center for Molecular Design and Biomimetics in the Biodesign Institute at Arizona State University. The themes of his research are structural DNA nanotechnology and DNA-directed self-assembly.