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Biodesign Directory Profile

Contact Information

(480)965-2805

Joshua LaBaer, MD, PhD

Virginia G. Piper Chair in Personalized Medicine

Director

The Biodesign Institute, Personalized Diagnostics

Bio

Visit the LaBaer Lab Web Site

Joshua LaBaer is one of the nation’s foremost investigators in the rapidly expanding field of personalized medicine. His efforts involve the discovery and validation of biomarkers — unique molecular fingerprints of disease — which can provide early warning for those at risk of major illnesses, including cancer and diabetes.

The Virginia G. Piper Center for Personalized Diagnostics (VGPCPD) has a highly multidisciplinary staff of molecular biologists, cell biologists, biochemists, software engineers, database specialists, bioinformaticists, biostatisticians, and automation engineers with individuals ranging from Ph.D. and M.D. degrees to graduate students to technical support individuals. An organizing principle of VGPCPD is the application of open reading frame clones to the high throughput (HT) study of protein function.

Dr. LaBaer was an early initiator and leader of the effort to build fully sequence-verified recombination-based clone sets for human genes and other model organisms now managed in an automated repository with more than 250,000 samples, which are openly shared with the scientific community. His laboratory has developed a number of methods to employ these clones, including HT protein expression and purification, and HT screens of ectopic protein expression in mammalian cells for relevant phenotypes.

In addition, his group invented a novel protein microarray technology, Nucleic Acid Programmable Protein Array, which has been used widely for biomedical research, including the recent discovery of a panel of 28 autoantibody biomarkers that may aid the early diagnosis of breast cancer.

Formerly founder and director of the Harvard Institute of Proteomics, LaBaer was recruited to ASU’s Biodesign Institute as the first Piper Chair in Personalized Medicine in 2009.

Dr. LaBaer completed both his medical internship and residency at the Brigham and Women’s Hospital and a clinical fellowship in oncology at the Dana-Farber Cancer Institute, both in Boston. He is a board certified physician in internal medicine and medical oncology and was an instructor and clinical fellow in medicine at Harvard Medical School. He has contributed more than 140 original research publications, reviews and chapters.

LaBaer is an associate editor of the Journal of Proteome Research and a member of the editorial boards of Analytical Biochemistry, Current Opinion in Biotechnology, Cancer Biomarkers, Molecular Biosystems, and Clinical Proteomics. He is a former member of the National Cancer Institute’s Board of Scientific Advisors and serves as chair of the National Cancer Institute’s Early Detection Research Network Executive Committee and Co-Chair of its Steering Committee. He is the president of the U.S. Human Proteome Organization. He also serves on a number of government and industry scientific advisory boards.

LaBaer earned his medical degree and a doctorate in biochemistry and biophysics, from the University of California, San Francisco.

Education:

1981 - B.S. University of California, Berkeley, California
1989 - Ph.D. University of California School of Medicine, San Francisco, California (Biochemistry and Biophysics)
1990 - M.D. University of California School of Medicine

Awards and Honors:

    1978 Edward Frank Kraft Prize for Outstanding Academic Achievement, University of California
    1977-1981 Regents Scholar, University of California
    1981 Phi Beta Kappa
    1981 Citation for Outstanding Student Research, UC Berkeley
    1981 University Medal for Most Distinguished Graduating Senior, UC Berkeley
    1981 Graduation with Highest Honors, UC Berkeley
    1985 Dean’s Prize for Student Research
    1986-1987 Chancellor’s Fellowship
    1989 Alpha Omega Alpha
    2001-04 Arthur and Rochelle Belfer Foundation Awardee, Breast Cancer Research Foundation
    2005- Breast Cancer Research Foundation
    2007 Kavli Frontiers of Science Symposium Recipient
    2009 The Otto Herz Memorial Lectureship in Cancer Research
    2009 The Virginia G. Piper Chair of Personalized Medicine
    2011 Health Care Hero [researcher/innovator]; Phoenix Business Journal

Major Research Interests:

    1. Finding drug and vaccine targets for biodefense pathogens
    2. Disease biomarker discovery
    3. Estrogen resistance in breast cancer
    4. Protein microarray technology and protein interaction mapping
    5. DNA-damage checkpoint regulation

Selected Publications

2014

  • Bhuiyan, S.; Sayeed, A.; Khanam, F.; Leung, D. T.; Rahman Bhuiyan, T.; Sheikh, A.; Salma, U.; Larocque, R. C.; Harris, J. B.; Pacek, M.; Calderwood, S. B.; LaBaer, J.; Ryan, E. T.; Qadri, F.; Charles, R. C.. Cellular and Cytokine Responses to Salmonella enterica Serotype Typhi Proteins in Patients with Typhoid Fever in Bangladesh. Am J Trop Med Hyg (2014) Refereed Articles.
  • Saul, J.; Petritis, B.; Sau, S.; Rauf, F.; Gaskin, M.; Ober-Reynolds, B.; Mineyev, I.; Magee, M.; Chaput, J.; Qiu, J.; LaBaer, J.. Development of a full-length human protein production pipeline.. Protein Sci (2014) Refereed Articles.
  • Seiler CY, Park JG, Sharma A, Hunter P, Surapaneni P, Sedillo C, Field J, Algar R, Price A, Steel J, Throop A, Fiacco M, LaBaer J.. DNASU plasmid and PSI:Biology-Materials repositories: resources to accelerate biological research.. Nucleic Acids Res (2014) Refereed Articles.
  • Seiler, C.; Park, J.; Sharma, A.; Hunter., P.; Surapaneni, P.; Sedillo, C.; Field, J.; Algar, R.; Price, A.; Steel, J.; Throop, A.; Fiacco, M.; LaBaer, J.. DNASU Plasmid and the PSI:Biology-Materials Repositories: Features and Resources to Accelerate Biological Research. Nucleic Acids Research (2014) Refereed Articles.
  • Skibinski, A.; Breindel, J. L.; Prat, A.; Galvan, P.; Smith, E.; Rolfs, A.; Gupta, P. B.; LaBaer, J.; Kuperwasser, C.. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep (2014) Refereed Articles.
  • Yu, X.; Bian, X.; Throop, A.; Song, L.; Del Moral, L.; Park, J.; Seiler, C. Y.; Fiacco, M.; Steel, J.; Hunter, P.; Saul, J.; Wang, J.; Qiu, J.; Pipas, J. M.; LaBaer, J.. Exploration of Panviral Proteome: High-Throughput Cloning and Functional Implications in Virus-host Interactions.. Theranostics (2014) Refereed Articles.
  • Yu, X.; Woolery, A. R.; Luong, P.; Hao, Y. H.; Grammel, M.; Westcott, N.; Park, J.; Wang, J.; Bian, X.; Demirkan, G.; Hang, H. C.; Orth, K.; LaBaer, J.. Click chemistry-based detection of global pathogen-host AMPylation on self-assembled human protein microarrays.. Mol Cell Proteomics (2014) Refereed Articles.

2013

  • Festa, F.; Steel, J.; Bian, X.; LaBaer, J.. High-throughput cloning and expression library creation for functional proteomics.. Proteomics (2013) Refereed Articles.
  • Kang D-W, P. J., Ilhan ZE, Wallstrom G, LaBaer J, Adams, JB, Krajmalnik_Brown. Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children.. PLoS ONE (2013) Refereed Articles.
  • Lee, J. R.; Magee, D. M.; Gaster, R. S.; LaBaer, J.; Wang, S. X.. Emerging protein array technologies for proteomics.. Expert review of proteomics (2013) Refereed Articles.
  • Miersch, S.; Bian, X.; Wallstrom, G.; Sibani, S.; Logvinenko, T.; Wasserfall, C. H.; Schatz, D.; Atkinson, M.; Qiu, J.; LaBaer, J.. Serological autoantibody profiling of type 1 diabetes by protein arrays.. Journal of Proteomics (2013) Refereed Articles.
  • Skates, S. J.; Gillette, M. A.; LaBaer, J.; Carr, S. A.; Anderson, L.; Liebler, D. C.; Ransohof, D.; Rifai, N.; Kondratovich, M.; Tezak, Z.; Mansfield, E.; Oberg, A. L.; Wright, I.; Barnes, G.; Gail, M.; Mesri, M.; Kinsinger, C. R.; Rodriguez, H.; Boja, E. Statistical Design for Biospecimen Cohort Size in Proteomics-based Biomarker Discovery and Verification Studies.. Journal of Proteome Research (2013) Refereed Articles.
  • Spera, R.; Festa, F.; Bragazzi, N.; Pechkova, E.; LaBaer, J.; Nicolini, C.. Conductometric Monitoring of Protein-Protein Interactions.. Journal of Proteome Research (2013) Refereed Articles.
  • Wallstrom, G.; Anderson, K. S.; LaBaer, J.. Biomarker discovery for heterogeneous diseases. Cancer epidemiology, biomarkers & prevention. American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. (2013) Refereed Articles.
  • Wang, J.; Barker, K.; Steel, J.; Park, J.; Saul, J.; Festa, F.; Wallstrom, G.; Yu, X.; Bian, X.; Anderson, K. S.; Figueroa, J. D.; LaBaer, J.; Qiu, J.. A versatile protein microarray platform enabling antibody profiling against denatured proteins.. Proteomics Clinical Applications (2013) Refereed Articles.
  • Yu, X.; Wallstrom, G.; Magee, D. M.; Qiu, J.; Mendoza, D. E.; Wang, J.; Bian, X.; Graves, M.; LaBaer, J.. Quantifying antibody binding on protein microarrays using microarray nonlinear calibration.. BioTechniques (2013) Refereed Articles.

2012

  • Festa F, Rollins SM, Vattem K, Hathaway M, Lorenz P, Mendoza EA, Yu X, Qiu J, Kilmer G, Jensen P, Webb B, Ryan ET, LaBaer J.. Robust microarray production of freshly expressed proteins in a human milieu.. Proteomics Clin Appl (2012) Refereed Articles.
  • Gibson, D.S.; Qiu, J.; Mendoza, E.A.; Barker, K.; Rooney, M.E., LaBaer, J.. Circulating and synovial antibody profiling of juvenile arthritis patients by nucleic acid programmable protein arrays.. Arthritis Res Ther. 2012 Apr 17;14(2):R77. [Epub ahead of print] (2012) Refereed Articles.
  • Hood LE, Omenn GS, Moritz RL, Aebersold R, Yamamoto KR, Amos M, Hunter-Cevera J, Locascio L; Workshop Participants.. New and improved proteomics technologies for understanding complex biological systems: addressing a grand challenge in the life sciences.. Proteomics. (2012) Refereed Articles.
  • LaBaer, J.. Improving international research with clinical specimens: 5 achievable objectives (Perspective).. Journal of Proteome Research (2012) Refereed Articles.
  • Manzano-Rom?n R, D?az-Mart?n V, Gonz?lez-Gonz?lez M, Matarraz S, Alvarez-Prado AF, Labaer J, Orfao A, P?rez-S?nchez R, Fuentes M.. Self-assembled Protein Arrays from an Ornithodoros moubata Salivary Gland Expression Library.. J Proteome Res (2012) Refereed Articles.
  • Takulapalli, B.R., Qiu J., Magee, D.M., Kahn. P., Brunner, A., Barker, K., Means, S., Miersch, S., Bian, X., Mendoza, A., Festa, F., Syal, K., Park, J.G., LaBaer, J., Wiktor, P.. High Density Diffusion-Free Nanowell Arrays.. Journal of Proteome Research (2012) Refereed Articles.
  • Wang J, Barker K, Steel J, Park J, Saul J, Festa F, Wallstrom G, Yu X, Bian X, Anderson KS, Figueroa J, Labaer J, Qiu J.. A versatile protein microarray platform enabling antibody profiling against denatured proteins.. Proteomics Clin Appl. (2012) Refereed Articles.
  • Wright C., Sibani S., Trudgian D., Fischer R., Kessler B., LaBaer J., Bowness P.. Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic Acid programmable protein arrays.. Mol Cell Proteomics (2012) Refereed Articles.

2011

  • Anderson, K. S.; Sibani, S.; Wallstrom, G.; Qiu, J.; Mendoza, E. A.; Raphael, J.; Hainsworth, E.; Montor, W. R.; Wong, J.; Park, J. G.; Lokko, N.; Logvinenko, T.; Ramachandran, N.; Godwin, A. K.; Marks, J.; Engstrom, P.; LaBaer, J.. Protein Microarray Signature of Autoantibody Biomarkers for the Early Detection of Breast Cancer.. Journal of Proteome Research (2011) Refereed Articles.
  • Anderson, K. S.; Wong, J.; D'Souza, G.; Riemer, A. B.; Lorch, J.; Haddad, R.; Pai, S. I.; Longtine, J.; McClean, M.; LaBaer, J.; Kelsey, K. T.; Posner, M.. Serum antibodies to the HPV16 proteome as biomarkers for head and neck cancer.. British Journal of Cancer (2011) Refereed Articles.
  • Cormier, C. Y.; Park, J. G.; Fiacco, M.; Steel, J.; Hunter, P.; Kramer, J.; Singla, R.; LaBaer, J.. PSI: Biology-materials repository: a biologist's resource for protein expression plasmids.. J Struct Funct Genomics (2011) Refereed Articles.
  • Gibson, D.S.; Rooney, M.E.; Finnegan, S.F.; Qiu, J.; Thompson, D.C.; LaBaer, J.; Pennington, S.R.; Duncan, M.W.. Biomarkers in rheumatology, now and in the future.. Rheumatology 2011 (2011) Refereed Articles.
  • Gonzalez-Malerva, L.; Park, J.; Zou, L. H.; Hu, Y. H.; Moradpour, Z.; Pearlberg, J.; Sawyer, J.; Stevens, H.; Harlow, E.; LaBaer, J.. High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.. Proceedings of the National Academy of Sciences of the United States of America (2011) Refereed Articles.
  • Hancock, W.; LaBaer, J.; Marko-Varga, G. A.. Journal of Proteome Research-10th Anniversary. Journal of Proteome Research (2011) Refereed Articles.
  • Link, A. J.; LaBaer, J.. Trichloroacetic acid (TCA) precipitation of proteins.. Cold Spring Harb Protoc (2011) Refereed Articles.
  • Link, A. J.; LaBaer, J.. Off-line desalting of peptide mixtures.. Cold Spring Harb Protoc (2011) Refereed Articles.
  • Link, A. J.; LaBaer, J.. Solution protein digest.. Cold Spring Harb Protoc (2011) Refereed Articles.
  • Link, A. J.; LaBaer, J.. Setup and demonstration of a nanoelectrospray ionization source and tandem mass spectrometry. Cold Spring Harb Protoc (2011) Refereed Articles.
  • Miersch, S.; LaBaer, J.. Nucleic Acid programmable protein arrays: versatile tools for array-based functional protein studies.. Curr Protoc Protein Sci (2011) Refereed Articles.
  • Qiu, J.; LaBaer, J.. Nucleic acid programmable protein array a just-in-time multiplexed protein expression and purification platform.. Methods Enzymol (2011) Refereed Articles.
  • Sheikh, A.; Khanam, F.; Sayeed, M. A.; Rahman, T.; Pacek, M.; Hu, Y.; Rollins, A.; Bhuiyan, M. S.; Rollins, S.; Kalsy, A.; Arifuzzaman, M.; Leung, D. T.; Sarracino, D. A.; Krastins, B.; Charles, R. C.; Larocque, R. C.; Cravioto, A.; Calderwood, S. B.; Bro. Interferon-gamma and Proliferation Responses to Salmonella enterica Serotype Typhi Proteins in Patients with S. Typhi Bacteremia in Dhaka, Bangladesh.. PLoS Negl Trop Dis (2011) Refereed Articles.
  • Spera, R.; Labaer, J.; Nicolini, C.. MALDI-TOF characterization of NAPPA-generated proteins.. J Mass Spectrom (2011) Refereed Articles.

2010

  • Anderson, K. S.; Wong, J.; Vitonis, A.; Crum, C. P.; Sluss, P. M.; LaBaer, J.; Cramer, D.. p53 Autoantibodies as Potential Detection and Prognostic Biomarkers in Serous Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention (2010) Refereed Articles.
  • Ceroni, A.; Sibani, S.; Baiker, A.; Pothineni, V. R.; Bailer, S. M.; LaBaer, J.; Haas, J.; Campbell, C. J.. Systematic analysis of the IgG antibody immune response against varicella zoster virus (VZV) using a self-assembled protein microarray.. Molecular Biosystems (2010) Refereed Articles.
  • Cormier, C. Y.; Mohr, S. E.; Zuo, D. M.; Hu, Y. H.; Rolfs, A.; Kramer, J.; Taycher, E.; Kelley, F.; Fiacco, M.; Turnbull, G.; LaBaer, J.. Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community.. Nucleic Acids Research (2010) Refereed Articles.
  • Jarvis, D. L.; Geisler, C.; Aumiller, J.; Jacob, B.; Moremen, K. W.; Steel, J.; LaBaer, J.. Repository of Recombinant Expression Constructs for Mammalian Glycosylation Enzymes: Baculovirus Vectors for Glycosyltransferase and Glycoside Hydrolase Production in Insect Cells.. Glycobiology (2010) Refereed Articles.
  • Moremen, K. W.; Naim, A. V.; Meng, L.; Ramiah, A.; Gao, Z.; Johnson, R.; Samli, E. F.; Strachan, H.; Xiang, Y.; Scott, I.; Gilbert, H. J.; Jarvis, D. L.; Steel, J.; LaBaer, J.. Repository of Recombinant Expression Constructs for Mammalian Glycosylation Enzymes: Production of Glycosyltransferases and Glycoside Hydrolases in Mammalian Cells.. Glycobiology (2010) Refereed Articles.
  • Ramirez, A. B.; Loch, C. M.; Zhang, Y. Z.; Liu, Y.; Wang, X. H.; Wayner, E. A.; Sargent, J. E.; Sibani, S.; Hainsworth, E.; Mendoza, E. A.; Eugene, R.; LaBaer, J., Urban, N. D.; McIntosh, M. W.; Lampe, P. D.. Use of a Single-Chain Antibody Library for Ovarian Cancer Biomarker Discovery.. Molecular & Cellular Proteomics (2010) Refereed Articles.
  • Wright, C.; Sibani, S.; Trudgian, D.; Fischer, R.; Kessler, B.; LaBaer, J.; Bowness, P.. Detection of multiple autoantibodies in patients with ankylosing spondylitis using nucleic acid programmable protein arrays.. Mol Cell Proteomics (2010) Refereed Articles.

2009

  • 87. Hughes, S. R.; Sterner, D. E.; Bischoff, K. M.; Hector, R. E.; Dowd, P. F.; Qureshi, N.; Bang, S. S.; Grynaviski, N.; Chakrabarty, T.; Johnson, E. T.; Dien, B. S.; Mertens, J. A.; Caughey, R. J.; Liu, S. Q.; Butt, T. R.; LaBaer, J.; Cotta, M. A.; Rich. Engineered Saccharomyces cerevisiae strain for improved xylose utilization with a three-plasmid SUMO yeast expression system.. Plasmid (2009) Refereed Articles.
  • Anderson, K. S.; Hodi, F. S.; Sasada, T.; Canning, C.; Hassett, M.; Mayer, E.; Hannagan, K.; Wong, J.; Colson, Y.; Shoji, B.; Najita, J.; Sibani, S.; LaBaer, J.; Winer, E. P.; Dranoff, G.. A phase I study of an autologous GM-CSF-secreting breast cancer vaccine.. Cancer Research (2009) Refereed Articles.
  • Anderson, K. S.; Sibani, S.; Wong, J.; Hainsworth, E.; Mendoza, E. A.; Eugene, R.; Raphael, J.; Logvinenko, T.; Ramachandran, N.; Godwin, A.; Marks, J.; Engstrom, P.; LaBaer, J.. Using custom protein microarrays to identify autoantibody biomarkers for the early detection of breast cancer.. Cancer Research (2009) Refereed Articles.
  • Gonzalez-Malerva, L. G.; Park, J.; Zou, L.; Hu, Y.; Moradpour, Z.; Pearlberg, J.; Harlow, E.; LaBaer, J.. Autophagy and Tamoxifen Resistance in Breast Cancer.. Cancer Research 2 (2009) Refereed Articles.
  • Hughes, S. R.; Hector, R. E.; Rich, J. O.; Qureshi, N.; Bischoff, K. M.; Dien, B. S.; Saha, B. C.; Liu, S. Q.; Cox, E. J.; Jackson, J. S.; Sterner, D. E.; Butt, T. R.; LaBaer, J.; Cotta, M. A.. Automated Yeast Mating Protocol Using Open Reading Frames from Saccharomyces cerevisiae Genome to Improve Yeast Strains for Cellulosic Ethanol Production.. Jala (2009) Refereed Articles.
  • Hughes, S. R.; Rich, J. O.; Bischoff, K. M.; Hector, R. E.; Qureshi, N.; Saha, B. C.; Dien, B. S.; Liu, S. Q.; Jackson, J. S.; Sterner, D. E.; Butt, T. R.; LaBaer, J.; Cotta, M. A.. Automated Yeast Transformation Protocol to Engineer Saccharomyces cerevisiae Strains for Cellulosic Ethanol Production with Open Reading Frames That Express Proteins Binding to Xylose Isomerase Identified Using a Robotic Two-Hybrid Screen.. Jala (2009) Refereed Articles.
  • Link, A. J. and J. LaBaer. Proteomics: A Cold Spring Harbor Laboratory Course Manual. (2009) Authored Books.
  • Montor, W. R.; Huang, J.; Hu, Y. H.; Hainsworth, E.; Lynch, S.; Kronish, J. W.; Ordonez, C. L.; Logvinenko, T.; Lory, S.; LaBaer, J.. Genome-Wide Study of Pseudomonas aeruginosa Outer Membrane Protein Immunogenicity Using Self-Assembling Protein Microarrays.. Infection and Immunity (2009) Refereed Articles.
  • Murphy, R. F.; LaBaer, J.. Locations Everyone: Lights, Camera, Action!. Journal of Proteome Research (2009) Refereed Articles.
  • Sheikh, A.; Khanam, F.; Rahman, T.; Pacek, M.; Hu, Y. H.; Baresch, A.; Bhuiyan, M. S.; Rollins, S.; Citorik, R.; Kalsy, A.; Charles, R.; LaRocque, R. C.; LaBaer, J.; Calderwood, S. B.; Harris, J. B.; Qadri, F.; Ryan, E. T.. Evaluation Of Interferon-Gamma Responses In Patients With Salmonella Enterica Serovar Typhi Bacteremia In Dhaka, Bangladesh.. American Journal of Tropical Medicine and Hygiene (2009) Refereed Articles.
  • Thanawastien, A.; Montor, W. R.; LaBaer, J.; Mekalanos, J. J.; Yoon, S. S.. Vibrio cholerae Proteome-Wide Screen for Immunostimulatory Proteins Identifies Phosphatidylserine Decarboxylase as a Novel Toll-Like Receptor 4 Agonist.. Plos Pathogens (2009) Refereed Articles.
  • Wong, J.; Sibani, S.; Lokko, N. N.; LaBaer, J.; Anderson, K. S.. Rapid detection of antibodies in sera using multiplexed self-assembling bead arrays.. Journal of Immunological Methods (2009) Refereed Articles.
  • Zhang, L. L.; Villa, N. Y.; Rahman, M. M.; Smallwood, S.; Shattuck, D.; Neff, C.; Dufford, M.; Lanchbury, J. S.; LaBaer, J.; McFadden, G.. Analysis of Vaccinia Virus-Host Protein-Protein Interactions: Validations of Yeast Two-Hybrid Screenings.. Journal of Proteome Research (2009) Refereed Articles.
  • Zhu, C.; Byers, K.; McCord, R. P.; Shi, Z. W.; Berger, M. F.; Newburger, D. E.; Saulrieta, K.; Smith, Z.; Shah, M. V.; Radhakrishnan, M.; Philippakis, A. A.; Hu, Y. H.; De Masi, F.; Pacek, M.; Rolfs, A.; Murthy, T.; LaBaer, J.; Bulyk, M. L.. High-resolution DNA-binding specificity analysis of yeast transcription factors.. Genome Research (2009) Refereed Articles.