- PhD University of Kentucky
Wayne Frasch has developed new assays to examine the rotation of single molecules of molecular motor proteins under a microscope. His lab focuses on the Fo and F1-ATPase rotary motors that comprise the FoF1 ATP synthase. This protein complex synthesizes the majority of ATP in almost all living organisms, which provides the energy for many cellular processes.
Professor Fraschs lab also creates nano-scale devices by assembling molecules of DNA and proteins in novel ways that can carry out specific tasks. These include the incorporation of the F1-ATPase molecular motor into devices that detect single molecules of toxins, drugs or DNA profiles of interest that can provide an early indication of infection or disease. Other nano-devices use the assembly of DNA molecules to make computations.