Human and Comparative Genomics
The Cartwright Lab is part of the the Biodesign Institute at Arizona State University. We are located in Tempe, AZ USA in the Phoenix metro area. We focus on developing, implementing, and applying novel methodologies to study large, complex genomic datasets.
Our research tackles many different questions in population genetics and molecular evolution, at the interface of biology, statistics, and computer science.
- The study of mutation patterns between human families and across species, using data from next-generation sequencing. This includes both indel and point-mutation patterns.
- Models of frequency-dependent selection, with applications to genomic data.
- New methods for alignment and phylogeny reconstruction that take into account the uncertainty of genomic data.
- New methods for simulating homologous sequences that can be optimized to mimic natural datasets.