Mark Holl

Deputy Director + Research Scientist, CXLS/CXFEL Science Program
Biodesign Beus CXFEL Lab
Applied Structural Discovery

Location: TEMPE

Contact Information
(480) 965-0544


Mark R. Holl received the B.S. degree in mechanical engineering from Washington State University, Pullman, in 1986, the M.S. and Ph.D. degrees in mechanical engineering from the University of Washington, Seattle, in 1995. Between undergraduate and graduate education, from 1987 to 1989, he worked at Boeing Commercial Aircraft in Manufacturing, Research, and Development in factory support and automated system functional test. From 1995 to 2000, he worked with Prof. Paul Yager in Bioengineering at the University of Washington in the development and commercialization of micro total analysis system technologies. He was a principal inventor with Dr. Yager of a laminate-based microfluidic technology and was a founding member of a startup company based on this work. From 2000 to 2006 he was a Research Assistant professor in Electrical Engineering at the University of Washington working on the development of microfluidic technologies for biomedical and genome science applications. From 2007-2009 he was lead for the engineering and field-implementation of  in the ASU/Biodesign called the Tubes-in-the-Desert (TID) APOLLO program project where bench scale and pilot plant scale photobioreactor systems were developed. In 2009 he joined the Biodesign Institute administrative team as the Associate Director of Technology Development for the Biodesign Institute Commercial Translation team, facilitating interactions between researchers and commercial sector interests. In 2014 he joined the Center for Applied Structural Discovery to lead proposal development and strategic initiatives for the center and to contribute his scientific and engineering skillsets strategically to ongoing and emerging opportunities.

Broad research interests include scientific instrument design, translation of university research to practical products and services, bioengineering, modeling and simulation (in service of design) of problems involving simultaneous understanding of coupled-domain physics phenomenon, systems integration for total analysis systems, microscale systems for biological applications, bioprocess automation, sensor development, and process characterization and control with emphasis on biomedical, genomic, proteomic, and therapeutic science applications. Current focused activities address current and emergent needs of the Center for Applied Structural Discovery (CASD) with collaborative efforts that span breadth CASD faculty, and selectively beyond to the ASU, national, and international research and commercial sector communities.