Research

Research Interests

Our research program is highly interdisciplinary which combines Chemistry, Biology, Physics and Material Science. Our goal is to achieve programmed design and assembly of biologically inspired nanomaterials and to explore its applications in nanoelectronics, controlled macromolecular interactions and biosensing.

Our research is focused in the following four themes:

  • Bio-Nanotechnology: Design of novel DNA nanostructures, implementation of the designed structure in the construction of patterned DNA arrays and nanomechanical devices. Develop modular methods to achieve biomimetic molecular motors.
  • Nanoelectronics: Utilize rationally designed DNA nanostructure to template nanoelectronic components such as nanoparticles or carbon nanotubes into functional nanodevices.
  • Macromolecule Structure Elucidation: Develop methods to self-assemble 2-D and 3-D protein arrays for structural determination using Electron Microscopy or X-ray Crystallography.
  • Biomolecular Imaging: Investigation of protein-DNA interactions using high resolution imaging technology such as Atomic Force Microscopy and Electron Microscopy.

Major techniques in the group include: DNA/RNA/Protein manipulation (gel electrophoresis, labeling, hybridization, PCR and footprinting, cloning), electron-beam lithography, Atomic Force Microscopy (AFM), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), Electron Microscopy (EM), Fluorescence Spectroscopy, UV-Vis, Circular Dichroism (CD) and chemical synthesis.