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Contact Information

480-727-0397

Yan Liu, PhD

Assistant Professor

The Biodesign Institute, Single Molecule Biophysics

Assistant Professor

College of Liberal Arts and Sciences, Chemistry and Biochemistry

Bio

Assistant Professor, Department of Chemistry and Biochemistry, College of Liberal Arts and Sciences

Office: DBA 130A, Lab: PSC-236
Phone: 480-965-2566, Lab Phone: 480-727-6482
Fax: 480-965-2747

Education

Ph.D., Columbia University, 2000

Research Areas

Biochemistry, physical chemistry

Research and Teaching Interests

The research program Yan Lui is involved in is highly interdisciplinary which combines Chemistry, Biology, Physics and Material Science. Their goal is to develop nanoparticle based multi-component and multi-functional nanostructures using self-assembly and DNA directed self-assembly, to characterize their unique optical properties, and explore their applications in bio-imaging, biosensing, etc.

The nanoparticles used include gold or silver nanoparticles, quantum dots, and magnetic nanoparticles. Surface modification of the nanoparticles by various bioconjugation methods will be explored to generate stable nanoparticles with desirable surface funtionalities. Self-assembly of DNA nanostructures form patterned DNA arrays, and the directed assembly of nanoparticles by the DNA templates generate uniquely functional nanodevices. Taking advantage of the precise spatial control of DNA nanostructures, and tunable size-or distance dependence of the properties of nanoparticles, multi-component structures with unique properties can be created. The various tools they use to characterize the nanoparticle based multi-compoent strucutures, include the microscopic imaging techniques of optical microscope, AFM, SEM or TEM, and spectral analysis tools, such as UV-Vis, fluorometer, surface Raman spectroscopy, etc.

Selected Publications

1. "Quantum Dot Bioconjugation during Core-Shell Synthesis," Q. Wang, Y. Liu, Y. Ke, H. Yan, Angew. Chem. Int. Ed.47, 316-319 (2008).

2. "Self-assembled Water-soluble Nanoarrays for Label Free RNA Hybridization Assays," Y. Ke, S. Lindsay, Y. Chang, Y. Liu and H. Yan, Science 319, 180-183 (2008).

3. "A Facile In situ Generation of Dithiocarbamate Ligands for Stable Gold Nanoparticle-Oligonucleotide Conjugates," J. Sharma, R. Chhabra, H. Yan and Y. Liu, Chem. Commun,2140-2142 (2008).

4. "Self-assembled DNA nanostructures for distance dependent multivalent ligand binding," S. Rinker, Y. Ke, Y. Liu, R. Chhabra, H. Yan*, Nature Nanotechnology 418-422 (2008).

5. "DNA Tile Directed Self-assembly of Quantum Dots into Two-dimensional Nanopatterns," J. Sharma, Y. Ke, C. Lin, R. Chhabra, Q. Wang, J. Nangreave, Y. Liu*, H. Yan*, Angew. Chem. Int. Ed.,47, 5157-5159 (2008).

Selected Publications

2008

  • Chhabra, R, Sharma, J, Liu, Yan, Yan, Hao. DNA Self-Assembly for Nanomedicine. Advanced Drug Delivery (2008).
  • Ding, B, Liu, Yan, Rinker, S, Yan, Hao. DNA-Templated Self-assembly of Protein Arrays and Highly Conductive Nanowires. Encyclopedia of Complexity and System Science (2008).
  • Liu, Yan, Ke, Y., Lindsay, S., Chang, Y., Liu, Y., Yan, H.. Self-assembled Water-soluble Nanoarrays for Label Free RNA Hybridization Assays. Science (2008).
  • Wang, Q., Liu, Yan, Ke, Y, Yan, Hao. Quantum Dot Bioconjugation during Core-Shell Synthesis. Angew. Chem. Int. Ed (2008).

2007

  • Chhabra, R, Sharma, J, Liu, Yan, Yan, Hao. Patterning Metallic Nanoparticles by DNA Scaffolds. Biological Studies and Applications of Engineered Nanostructures (2007).
  • Lin, C., Liu, Yan, Yan, Hao. Self-assembled Combinatorial Encoding Nanoarrays for Multiplexed Biosensing. Nano Lett (2007).
  • Liu, Yan, Chhabra, R., Sharma, J., Ke, Y., Liu, Y., Rinker, S., Lindsay, S., Yan*, H.. Spatially Addressable Multi-protein Nanoarrays Templated by Aptamer Tagged DNA Nano-architectures. J. Am. Chem. Soc. (2007).
  • Liu, Yan, Lin, C., Liu, Y., Mertig, M., Gu, J., Yan*, H.. Functional DNA Nanotube Arrays: Bottom-up Meets Top-down. Angew. Chem. Int. Ed. (2007).
  • Liu, Yan, Lin, C., Wang, X., Liu, Y., Seeman, N. C., Yan, H.. Rolling Circle Enzymatic Replication of a Complex Multi-Crossover DNA Nanostructure. J. Am. Chem. Soc. (2007).
  • Liu, Yan, Wang, Q., Liu, Y., Yan*, H.. Mechanism of a Self-templating Synthesis of Monodispersed Hollow Silica Nanospheres with Tunable Size and Shell Thickness. Chem. Commun. (2007).
  • Liu, Yan, Wang, Q., Xu, Y., Zhao, X., Chang, Y., Liu, Y., Jiang, L., Sharma, J., -K. Seo*, D., Yan*, H.. A Facile One-step In situ Functionalization of Quantum Dots with Preserved Photoluminescence for Bioconjugation. J. Am. Chem. Soc. (2007).
  • Liu, Yan, Williams, B., Lund, K., Liu, Y., Yan*, H., Chaput, J.. Self-assembled Peptide Nanoarrays: An Approach to Studying Protein-protein Interactions. Angew. Chem. Int. Ed. (2007).
  • Wang, Q, Liu, Yan, Yan, H. Lay-by-layer growth of superparamagnetic, fluorescent barcode nanospheres. Nanotechnology (2007).

2006

  • Chhabra, R, Sharma, J, Liu, Yan, Yan, Hao. Addressable Molecular Tweezers for DNA templated coupling reactions. Nano Lett (2006).
  • J Zhang, Y, Liu, Yan, Yan, Hao. Periodic Square-like gold nanoparticle arrays templated by a DNA nanogrids on a surface. Nano Lett (2006).
  • Ke, Y, Liu, Yan, Zhang, J, Yan, Hao. A Study of DNA tube formation mechanisms using 4-, 8- and 12-helix DNA nanostructures. J. Am. Chem. Soc (2006).
  • Lin, C, Katilius, E, Liu, Yan, Yan, Hao. Self-assembled Signaling Aptamer Nanoarrays for Protein Detection. Angew. Chem. Int. Ed (2006).
  • Lin, C, Liu, Yan, Rinker, S, Yan, Hao. DNA tile Based Self-assembly: Building Complex Nano-architectures. ChemPhysChem (2006).
  • Lin, L, Wang, H, Liu, Yan, Yan, Hao, Lindsay, S. Recognition imaging with a DNA aptamer. Biophysical J (2006).
  • Lund, K, Liu, Yan, Yan, Hao. Combinatorial Self-assembly of DNA Nanostructures. Organic and Biomolecular Chemistry (2006).
  • Lund, K, Williams, B, Ke, Y G, Liu, Yan, Yan, Hao. DNA nanotechnology: a rapidly evolving field. Current Nanoscience (2006).
  • Rinker, S, Liu, Yan, Yan, H. Two Dimensional LNA/DNA arrays: estimating the helicity of LNA/DNA hybrid duplex. Chem. Commum (2006).
  • Sharma, J, Chhabra, R, Liu, Yan, Ke, Y, Yan, Hao. DNA templated self-assembly of two-dimensional and periodical gold nanoparticle arrays. Angew. Chem. Int. Ed (2006).

2005

  • Liu, Yan, Hong, L, Simon, J D. Comparison of the Structural and Chemical Properties of Melanosomes Isolated from Retinal Pigment Epithelium, Iris and Choroids of Newborn and Mature Bovine Eyes. Pigment Cell Research (2005).
  • Liu, Yan, Hong, L, Wakamatsu, K, Ito, S, Adhyaru, B, Cheng, Chi-Yuan, Bowers, C, Simon, J D. Comparison of Structural and Chemical Properties of Black and Red Human Hair Melanosomes. Photochemistry and Photobiology (2005).
  • Liu, Yan, Ke, Y, Yan, Hao. Self-assembly of symmetric finite size DNA nanoarrays. J. Am. Chem. Soc (2005).
  • Liu, Yan, Lin, C X, Li, H, Yan, Hao. Aptamer directed Self-assembly of Proteins on a DNA Nanostructure. Angew. Chem. Int. Ed (2005).
  • Liu, Yan, Simon, J D. Metal Ion Interactions and the Structural Organization of Sepia Eumelanin. Pigment Cell Research (2005).
  • Liu, Yan, Yan, Hao. Modular Self-assembly of DNA Lattice with Tunable Periodicity. Small (2005).
  • Lund, K, Liu, Yan, Lindsay, S, Yan, Hao. Self-assembling Molecular Pegboard. J. Am. Chem. Soc (2005).
  • Park, S H, Yin, P, Liu, Yan, Reif, J, LaBean, T H, Yan, Hao. Programmable DNA Self-assemblies for Nanoscale Organization of Ligands and Proteins. Nano Lett (2005).
  • Samokhvalov, A, Hong, L, Liu, Yan, Garguilo, J, Nemanich, R J, Edwards, G S, Simon, J D. Oxidation Potentials of Human Eumelanosomes and Pheomelanosomes. Photochemistry and Photobiology (2005).
  • Yan, Hao, Liu, Yan. DNA Nanotechnology: An Evolving Field. Nanotechnology: Science and Computation (2005).

2004

  • Hong, L, Liu, Yan, Simon, J D. Binding of metal ions to melanin and Their Effects on Aerobic Reactivity. Photochemistry and Photobiology (2004).
  • Liu, Yan, Hong, L, Kampf, V R, Wakamatsu, K, Ito, S, Simon, J D. Ion-Exchange and Adsorption of Fe(III) by Sepia Eumelanin. Pigment Cell Research (2004).
  • Samokhvalov, A, Liu, Yan, Simon, J D. Characterization of the Fe(III)-binding site in Sepia eumelanin by resonance Raman confocal microspectroscopy. Photochemistry and Photobiology (2004).

2003

  • Edens, G, Liu, Yan, Mauzerall, D. Pressure cell for Time-Resolved Calorimetric Measurements of Photo-Initiated Reactions: Fractional Millisecond and Longer. Review Scientific Instruments (2003).
  • Liu, Yan, Kempf, V, Nofsinger, J B, Weinert, E E, Rudnicki, M, Wakamatsu, K, Ito, S, Simon, J D. Comparison of the Structural and Physical Properties of Human Eumalanin Following Enzymatic or Acid/Base Extraction. Pigment Cell Research (2003).
  • Liu, Yan, Simon, J D. Isolation and Biophysical Studies of Natural Eumelanins: Applications of Imaging Technologies and Ultrafast Spectroscopy. (2003).
  • Liu, Yan, Simon, J D. The Effect of Preparation Procedures on the Morphology of Melanin from Ink Sac of Sepia officinalis. Pigment Cell Research (2003).
  • Mauzerall, D, Liu, Yan, Edens, G J, Grzymski, J. Measurement of enthalpy and volume changes in photoinitiated reactions on the ms timescale with a novel pressure cell. Photochemical and Photobiological Science (2003).

2002

  • Nofsinger, J B, Liu, Yan, Simon, J D. Aggregation of Eumelanin mitigates photogeneration of reactive oxygen species. Free Radical Biology and Medicine (2002).
  • Simon, J D, Liu, Yan, Nofsinger, J B. Assembly and Aerobic Photoreactivity of Melanin. (2002).

2001

  • Liu, Yan, Yan, E CY, Eisenthal, K B. Effects of bilayer surface charge density on molecular adsorption and transport across liposome bilayers. Biophys. J (2001).
  • Liu, Yan, Yan, E CY, Zhao, X, Eisenthal, K B. Surface potential of charged liposomes determined by second harmonic generation. Langmuir (2001).
  • Shang, X, Liu, Yan, Yan, E CY, Eisenthal, K B. Effect of Buffer Species in the Aqueous Solution on the Permeability of Malachite Green across Liposome Bilayer: Kinetic Study by SHG. J. Phys. Chem. B (2001).
  • Yan, E CY, Liu, Yan, Eisenthal, K B. In situ studies of molecular transfer between microparticles by second-harmonic generation. J. Phys. Chem. B (2001).