Biodesign Directory Profile
Stuart Lindsay, PhD Regents Professor
Edward and Nadine Carson Presidential Chair in Physics
The Biodesign Institute, Single Molecule Biophysics
College of Liberal Arts and Sciences, Physics
College of Liberal Arts and Sciences, Chemistry and Biochemistry
Office: DBA 120E
Ph.D., University of Manchester, U.K., 1976
RESEARCH AND TEACHING INTERESTS
Stuart Lindsay, Ph.D., specializes in biophysics at the molecular level and scanning probe microscopy. Much of his work is aimed at speedier diagnosis and an understanding of the molecular basis of disease. He holds 29 US patents and is a technology advisor for the Atomic Force Microscope Division of Agilent Technologies. Agilent has acquired Molecular Imaging Corporation, which he co-founded in 1993.
Dr. Lindsay's lab conducts innovative research in biological physics, molecular electronics, solar energy and condensed matter physics. The Lindsay Lab researchers are interested in how genes work, and study the way in which proteins change DNA structure to switch genes on and off. They are also interested in the chemistry and physics of the liquid-solid interface, and are trying to understand electrochemical and charge transfer processes at the single-molecule level. One project that Dr. Lindsay is pursuing is a new method of DNA sequencing to allow much faster and cheaper sequencing of individual human genomes. His radical approach involves electron tunneling through electrodes funtionalized with molecules that recognize the DNA bases.
His 29 patents cover mostly technology for atomic force microscopy and new devices based on molecular electronics. After receiving his PhD in Physics from the University of Manchester, Dr. Lindsay spent two years as a consultant at Philips Industries in London before joining the faculty at ASU. He has been at ASU for 30 years. His body of published work comprises over 200 articles in peer-reviewed journals. He is the author of the first comprehensive text for nanoscience, "Introduction to Nanoscience" (OUP, 2009). Dr. Lindsay sits on the editorial boards of Biophysical Journal and AIP Press International Series in Basic and Applied Biological Physics. He also holds the position of Associate Editor for Probe Microscopy at Ultramicroscopy. He is a fellow of the American Association for the Advancement of Science and the American Physical Society.
1. ?Tunneling readout of hydrogen-bonding based recognition? Chang, S., He, J., Kibel, A., Lee, M., Sankey, O. F., Zhang, P. & Lindsay, S. M. Nature Nanotechnology 4, 297-301 (2009).
2. "A Molecular Switch Based on Potential-Induced Changes of Oxidation State," F. Chen, J. He, C. Nuckolls, T. Roberts, J.E. Klare and S. Lindsay, Nano Letters 5, 503-506 (2005).
3. ?Reproducible Measurement of Single-Molecule Conductivity? X. D. Cui, A. Primak, X. Zarate, J. Tomfohr, O. F. Sankey, A. L. Moore, T. A. Moore, D. Gust, G. Harris and S. M. Lindsay, Science 294, 571-574 (2001).
4. Single-molecule recognition imaging microscopy, C. Stroh, H. Wang, R. Bash, B. Ashcroft, J. Nelson, H. Gruber, D. Lohr, S. M. Lindsay, and P. Hinterdorfer, Proc. Natl. Acad. Sci (USA)., 101 12503?12507 (2004).
5. ?Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays? Yonggang Ke, Stuart Lindsay, Yung Chang, Yan Liu, Hao Yan, Science 319 180-183 (2008).