Anb

Biodesign Directory Profile

Contact Information

(480)727-8228

Hugh Mason, PhD

Associate Professor

The Biodesign Institute, Infectious Diseases and Vaccinology

Associate Professor

College of Liberal Arts and Sciences, School of Life Sciences

Bio

Publications, primary peer-reviewed:

 

1.       Mason HS, Matsuda K. (1985) Polyribosome metabolism, growth and water status in the growing tissues of osmotically stressed plant seedlings. Physiol. Plant. 64: 95-104.

2.       Mason H, Mullet J, Boyer J. (1988) Polysomes, messenger RNA and growth in soybean stems during development and water deficit. Plant Physiol. 86:725-733.

3.       Mason H, Guerrero F, Boyer J, Mullet J. (1988) Proteins homologous to leaf storage proteins are abundant in stems of soybean seedlings. Analysis of proteins and cDNAs. Plant Mol. Biol. 11:845-856. 

4.       Klein RR, Mason HS, Mullet JE. (1988) Light-regulated translation of chloroplast proteins. I. Transcripts of PsaA-PsaB, PsbA and RbcL are associated with polysomes in dark-grown and illuminated barley seedlings. J. Cell Biol. 106: 289-301.

5.       Creelman RA, Mason HS, Bensen RJ, Boyer JS, Mullet JE. (1989) Water deficit and ABA cause differential inhibition of shoot vs. root growth in soybean seedlings. Analysis of growth, sugar accumulation and gene expression. Plant Physiol. 92: 205-214. 

6.       Mason H, Mullet J. (1990) Expression of two soybean vegetative storage protein genes during development and in response to water deficit, wounding and jasmonic acid. Plant Cell 2:569-579. 

7.       Mason H, DeWald D, Creelman R, Mullet J. (1992) Co-regulation of soybean vegetative storage protein gene expression by methyl jasmonate and soluble sugars. Plant Physiol. 98:859-867. 

8.       DeWald DB, Mason HS, Mullet JE. 1992.  The soybean vegetative storage proteins VSPa and VSPß are acid phosphatases active on polyphosphates. J. Biol. Chem.  267: 15958-15964.

9.       Mason H, Lam D, Arntzen CJ. (1992) Expression of hepatitis B surface antigen in transgenic plants. Proc. Natl. Acad. Sci. USA 89:11745-11749.

10.    Mason H, DeWald D, Mullet J. (1993) Identification of a methyl jasmonate responsive domain in the soybean vspB promoter. Plant Cell 5:241-251.

11.    May GD, Afza R, Mason HS, Weicko A, Novak F, Arntzen CJ. (1995) Genetic transformation of banana (Musa acuminata). Bio/Technology13:486-492.

12.    Haq TA, Mason HS, Clements JD, Arntzen CJ. (1995) Oral immunization with a recombinant bacterial antigen produced in transgenic plants.  Science268:714-716.

13.    Thanavala Y, Yang Y-F, Lyons P, Mason HS, Arntzen C. (1995) Immunogenicity of transgenic plant-derived hepatitis B surface antigen.  Proc. Natl. Acad. Sci. USA 92:3358-3361.

14.    Mason HS, Ball J, Shi JJ, Jiang X, Estes MK, Arntzen CJ (1996) Expression and immunogenicity of Norwalk virus capsid protein from transgenic tobacco and potato.  Proc. Natl. Acad. Sci. USA 93:5335-5340

15.    Mason HS, Haq TA, Clements JD, Arntzen CJ (1998) Edible vaccine protects mice against E. coli heat-labile enterotoxin (LT): potatoes expressing a synthetic LT-B gene. Vaccine 16:1336-1343.

16.    Tacket CO, Mason HS, Losonsky G, Clements JD, Levine MM, Arntzen CJ (1998) Immunogenicity in humans of a recombinant bacterial antigen delivered in transgenic potato. Nature Medicine 4:607-609.

17.    Tacket CO, Mason HS, Losonsky G, Estes MK, Levine MM, Arntzen CJ (2000) Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis. 182: 302-305.

18.    Dogan B, Mason HS, Richter L, Hunter JB, Shuler ML (2000) Process options in hepatitis B surface antigen extraction from transgenic potato. Biotechnol. Progress 16:435-441.

19.    Richter L, Thanavala Y, Arntzen CJ, Mason HS (2000) Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnol. 18:1167-1171.

20.    Mor TS, Sternfeld M, Soreq H, Arntzen CJ, Mason HS (2001) Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotechnol. Bioeng. 75: 259-266.

21.    Kong Q, Richter L, Yang Y-F, Arntzen CJ, Mason HS, Thanavala Y  (2001) Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. USA 98:11539-11544.

22.    Smith ML, Keegan ME, Mason HS, Shuler ML (2002) Factors important in the extraction, stability and in vitro assembly of the hepatitis B surface antigen derived from recombinant plant systems. Biotechnol. Prog. 18(3): 538-550.

23.    Smith ML, Mason HS, Shuler ML (2002) Hepatitis B surface antigen (HBsAg) expression in plant cell culture; the kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnol.  Bioeng. 80, 812-822.

24.    Chikwamba R, Cunnick J, Hathaway D, McMurray J, Mason HS, Wang K (2002).  A functional antigen in a practical crop: Maize synthesized LT-B protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT).  Transgenic Research. 11:479-493.

25.    Chikwamba R, McMurray J, Frame B, Scott  P, Mason H, Wang K (2002). Expression of a bacterial antigen in maize: The role of regulatory sequences, inheritance and level of expression of the synthetic E. coli heat labile toxin B sub-unit (LT-B) in maize. Molecular Breeding 10: 253 - 263.

26.    Cao J, Ibrahim  H, Garcia J, Mason H, Granados  RR, Earle ED (2002)Transgenic tobacco plants carrying a baculovirus enhancin gene slow development and enhance mortality of Trichoplusia ni larvae. Plant Cell Rep 21:244-250.

27.    Mor TS, Moon Y-S, Palmer KE, Mason HS (2003) Geminivirus vectors for high level expression of foreign proteins in plant cells. Biotechnol. Bioeng. 81: 430-437.

28.    Sojikul P, Buehner N, Mason HS (2003) A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells. Proc. Natl. Acad. Sci. USA 100:2209-2214.

29.    Walmsley AM, Kirk DD, Mason HS (2003) Passive immunization of mice pups through oral immunization of dams with a plant-derived vaccine. Immunol. Lett. 86:71-76.

30.    Walmsley AM, Alvarez ML, Jin Y, Kirk DD, Lee SM, Pinkhasov J, Rigano MM, Arntzen CJ, Mason HS (2003) Expression of the B subunit of Escherichia coli heat-labile enterotoxin as a fusion protein in transgenic tomato. Plant Cell Rep., 21:1020-1026.

31.    Warzecha H, Mason HS, Lane C, Tryggvesson A, Rybicki E, Williamson A, Clements JD, Rose RC (2003) Oral immunogenicity of human papillomavirus-like particles expressed in potato. J. Virol 77:8702-8711.

32.    Smith ML, Richter L,. Arntzen CJ, Shuler ML, Mason HS (2003) Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine 21:4011-4021.

33.    Chikwamba RK, Scott MP, Mejia LB, Mason HS, Wang K (2003) Localization of a bacterial protein in starch granules of transgenic maize kernels. Proc. Natl. Acad. Sci. USA 100:11127-11132.

34.    Judge NA, Mason HS, O’Brien AD (2004) Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces. Infect. Immun. 72:168-175.

35.    Huang Z, Mason HS (2004) Conformational analysis of hepatitis B surface antigen fusions in an Agrobacterium-mediated transient expression system. Plant Biotechnol. J. 2:241-249.

36.    Thanavala Y, Mahoney M, Pal S, Scott A, Richter L, Natarajan N, Goodwin P, Arntzen CJ, Mason HS (2005) Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci. USA102:3378-3382.

37.    Huang Z, Elkin G, Maloney BJ, Beuhner N, Arntzen CJ, Thanavala Y, Mason HS (2005) Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses. Vaccine 23:1851-1858.

38.    Maloney BJ,Takeda N, Suzaki Y, Ami Y, Li TC, T Miyamura, Arntzen CJ, Mason HS (2005) Challenges in creating a vaccine to prevent hepatitis E. Vaccine23:1870-1874.

39.    Mihalek CA, Webb S, Miller T, Fanton M, Kirk D, Cardineau G, Mason H, Walmsley A, Artnzen A, Van Eck J (2005) Development of plant cell produced vaccines for animal health applications. Proc. Ann. Meeting U.S. Animal Health Assoc. 108:158-163.

40.       Zhang X, Mason HS (2005) Bean yellow dwarf virus replicons for high-level transgene expression in transgenic plants and cell cultures. Biotechnol Bioeng. 93(2):271-9.

41.       Huang Z, Santi L, LePore K, Kilbourne J, Arntzen CJ, Mason HS (2006) Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine, 24(14):2506-2513.

42.       Santi L, Giritch A, Roy C, Marillonnet S, Klimyuk V, Gleba Y, Webb R, Arntzen C, Mason H (2006) Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc. Natl. Acad. Sci. USA 103(4):861-866.

43.       Saldaña S, Guadarrama FE, de Jesus Olivera Flores T, Arias N, López S, Arias C, Ruiz R, Mason H, Mor T, Richter L, Arntzen CJ, Gómez-Lim MA (2006) Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol. 19(1):42-53.

44.       Alvarez ML, Pinyerd HL, Crisantes JD, Rigano MM, Pinkhasov J, Walmsley AM,Mason HS, Cardineau, GA (2006) Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine24(14): 2477-2490.

45.       Zhang X, Buehner NA, Hutson AM, Estes MK, Mason HS (2006) Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol. J. 4: 419–432.

46.       Becerra-Arteaga A, Mason HS, Shuler ML (2006) Production, Secretion, and Stability of Human Secreted Alkaline Phosphatase in Tobacco NT1 Cell Suspension Cultures. Biotechnol. Prog., 22(6):1643-1649.

47.       Collens JI, Mason HS, Curtis WR (2007) Agrobacterium-mediated viral vector-amplified transient gene expression in Nicotiana glutinosa plant tissue culture. Biotechnol Prog. 23(3):570-6. Epub 2007 Apr 11.

48.       Van Eck J, Conlin B, Garvin D, Mason H, Navarre D, Brown C (2007) Enhancing [[beta]]-carotene content in potato by RNAi-mediated silencing of the [beta]-carotene hydroxylase gene. American J. Potato Res., 84 (4):331-342.

49.       Huang Z, LePore K, Elkin G, Thanavala Y, Mason HS (2008) High-yield rapid production of hepatitis B surface antigen in plant leaf by a viral expression system. Plant Biotechnol. J. 6 (2): 202–209.

50.       Santi L, Batchelor L, Huang Z, Hjelm B, Kilbourne J, Arntzen CJ, Chen Q, Mason HS (2008) An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine26:1846-1854.

51.       Huang Z, Chen Q, Hjelm B, Arntzen C, Mason H (2009) A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol. Bioeng. 103: 706-714.

52.       Webster DE, Wang L, Mulcair M, Ma C, Santi L, Mason HS, Wesselingh SL, Coppel RL (2009) Production and characterisation of an orally immunogenic Plasmodium antigen in plants using a virus-based expression system. Plant Biotechnol. J., 7: 846–855.

53.       Del Prete G, Santi L, Andrianaivoarimanana V, Amedei A, Domarle O, D' Elios MM, Arntzen CJ, Rahalison L, Mason HS (2009) Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system. Int J Immunopathol Pharmacol. 22(1):133-43.

54.       Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, *MasonHS, *Chen Q (2010) High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol. Bioeng.106: 9-17 PMID: 20047189. *co-corresponding authors

55.       Martinez CA, Topal E, Giulietti AM, Talou JR, Mason HS (2010) Exploring different strategies to express Dengue virus envelope protein in a plant system. Biotechnol. Lett, 32(6):867-75.

56.       Daskalova SM, Radder JE, Cichacz ZA, Olsen SH, Tsaprailis G, Mason H, Lopez LC (2010) Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol. 2010 Aug 24;10:62. PMID: 20735851.

57.       Pinkhasov J, Alvarez ML, Pathangey LB, Tinder TL, Mason HS, Walmsley AM, Gendler SJ, Mukherjee P (2010) Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model. Cancer Immunol Immunother 59: 1801-1811.

58.       Mathew LG, Maloney B, Takeda N, Mason HS (2011) Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants. Plant Mol Biol. 75: 263-275.

59.       Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS (2011) Expression of an immunogenic Ebola immunecomplex in Nicotiana benthamiana. Plant Biotechnol. J., 9(7):807-16.

60.       Pinkhasov J, Alvarez ML, Rigano MM, Piensook K, Larios D, Pabst M, Grass J, Mukherjee P, Gendler SJ, Walmsley AM, Mason HS (2011) Recombinant plant-expressed tumor-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. Plant Biotechnol. J. 9(9):991-1001.

61.       Phoolcharoen W, Dye JM, Kilbourne J, Piensook K, Pratt WD, Arntzen CJ, Chen Q, Mason HS, Herbst-Kralovetz MM (2011) A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge. Proc. Natl. Acad. Sci. USA 108(51):20695-20700.

Publications, invited reviews and chapters:

1.       Mason HS, Arntzen CJ (1995) Transgenic plants as vaccine production systems. Trends Biotechnol. 13:388-392.

2.       Richter L, Mason HS, Arntzen CJ (1996) Transgenic plants created for oral immunization against diarrheal diseases.  J. Travel. Med. 3:52-56

3.       May GD, Mason HS, Lyons P (1996) Application of transgenic plants as production systems for pharmaceuticals. In: Fuller G, Bills D, McKeon T, Eds. ACS Symposium Series --Agriculture as a Renewable Source of Raw Materials. Washington, DC: ACS Books, pp. 194-204.

4.       Lyons PC, May GD, Mason HS, Arntzen CJ (1996) Production of protein pharmaceuticals in transgenic plants. Pharmaceutical News 3:7-12.

5.       Welter LM, Mason HS, Lu W, Lam DMK, Welter MW (1996) Effective immunization of piglets with transgenic potato plants expressing a truncated TGEV S protein. In: Vaccines: New Technologies and Applications.  (Cambridge Healthtech Institute).

6.       Arntzen CJ, Mason HS(1997) Oral vaccine production in the edible tissues of transgenic plants. In: New Generation Vaccines, Second Edition (Eds. Levine MM, Woodrow GC, Kaper JB, Cobon GS) Marcel Dekker, New York, Pages 263-277.

7.       Mason HS, Tacket CO, Richter LJ, Arntzen CJ (1998) Subunit vaccines produced and delivered in transgenic plants as “edible vaccines” Res. Immunol. 149:71-74.

8.       Mason HS, Arntzen CJ (1998)  Edible vaccines -- the future for paediatric vaccines delivery?  Vaccines: Children and Practice, 1:13-15.

9.       Wong SY, Ho KS, Mason HS, Arntzen CJ (1998) Edible vaccines. Science & Medicine 5:36-45.

10.    Walmsley AM, Mason HS, Arntzen CJ (1999) The development of transgenic plants as edible vaccines.  Mucosal Immunol. Update 7:12-14.

11.    Tacket CO, Mason HS (1999) A review of oral vaccination with transgenic vegetables. Microbes & Infection 1:1-7.

12.    Mor TS, Richter L, Mason HS (1999) Expression of rotavirus proteins in transgenic plants. In: Plant Biotechnology and In Vitro Biology in the 21st Century (Altman A, Ziv M, Izhar S, eds.), pp.  521-524, Proceedings of the IXth International Congress of the International Association of Plant Tissue Culture and Biotechnology, Kluwer Academic Publishing, Dordrecht, The Netherlands.

13.    Mason HS (2002) Plant-based vaccines:  Expression and oral immunogenicity. In Vitro Cell. Devel. Biol. – Plant 38:237-240.

14.    Mason HS, Warzecha H, Mor TS, Arntzen CJ (2002) Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol. Med.8:324-329.

15.    Warzecha H, Mason HS (2003) Benefits and risks of antibody and vaccine production in transgenic plants. J. Plant Physiol. 160:755-764.

16.    Mason HS, Chikwamba R, Santi L, Mahoney RT, Arntzen CJ (2004) Antigen delivery systems:  Transgenic plants for mucosal vaccines. In: Mucosal Immunology, 3rd Edition. Section D. Mucosal Vaccines (McGhee JR, Mestecky JF, Eds) Elsevier Science, London, 2004, pp. 1053-1060.

17.    Mason HS (2004) Vaccines produced in transgenic plants. In: Encyclopedia of Plant and Crop Science (Goodman RM, Ed.). Marcel Dekker, New York.

18.    Mor TS, Mason HS (2003) Plants as a source for subunit vaccines. In: Handbook of Plant Physiology (Christou P, Klee H, Eds.) John Wiley & Sons, Ltd., West Sussex, 2004, pp. 768-780.

19.    Mor TS, Mason HS, Kirk D, Arntzen CJ, Cardineau GA (2004) Plants as a delivery vehicle for orally delivered subunit vaccines. In: New Generation Vaccines, Third Edition (Levine M, Ed.), pp. 305-311. Marcel Dekker, New York.

20.    Arntzen CJ, Mahoney RT, Mason HS, Kirk DD (2005) Oral Vaccines Derived from Transgenic Plants. In: Vaccines: Preventing disease and protecting health.

21.    Khalsa G, Mason HS, Arntzen CJ (2004) Plant-Derived Vaccines: Progress and Constraints. In: Fischer R, Schillberg S, Eds. Molecular Farming, pp. 135-160. (Published Online: 6 Jun 2005)

22.    Santi L, Huang Z, Mason H (2006) Virus-like particles production in green plants. Methods 40(1):66-76.

23.    Thanavala Y, Huang Z, Mason HS (2006) Plant-derived vaccines: a look back at the highlights and a view to the challenges on the road ahead. Expert Rev Vaccines 5(2):249-260.

24.    Santi L, Mason HS (2006) Protective plague vaccine produced in tobacco leaves. Information Systems for Biotechnology News Report, Virginia Tech University, April 2006, http://www.isb.vt.edu/articles/apr0602.htm.

25.    Mayo KJ, Gonazales BJ, Mason HS (2006) Genetic transformation of tobacco NT1 cells with Agrobacterium tumefaciens. Nat Protoc. 1(3):1105-11.http://www.natureprotocols.com/2006/08/17/genetic_transformation_of_toba.php

26.    Arntzen C, Mason H, Khalsa G (2007) Designing and delivering plant-based vaccines for the developing world. PETRIA J. Plant Pathol. 17:55-70.

27.    Daniell H, Singh ND, Mason H, Streatfield SJ (2009) Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Sci. 14(12):669-79.

28.    Santi L, Mason HS (2010) Plants as biofactories for vaccine production. Encyclopedia of Biotechnology in Agriculture and Food DOI: 10.1081/EBAF-120042331 (D. Heldman, A. Bridges, D.G. Hoover, and M. Wheeler, eds.). Taylor & Francis, New York.

29.    Herbst-Kralovetz M, Mason HS (corresponding author), Chen Q (2010) Norwalk virus-like particles as vacines. Expert Rev. Vaccines 9(3):299-307.

30.    Mason HS, Herbst-Kralovetz MM (2010) Plant-derived antigens as mucosal vaccines. In Current Topics in Microbiology and Immunology, Mucosal Vaccines: Modern Concepts, Strategies, and Challenges (P. Kozlowski, ed.) Springer, Heidelberg, accepted.

31.    Chen Q, He J, Phoolcharoen W, Mason HS (2011) Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Hum Vaccin. Mar 1;7(3). [Epub ahead of print] PMID: 21358270


Selected Publications

2013

  • Mestecky J, Russell MW, Kelsall BL, Ogra PL, Strober W, Lambrecht BN, Cheroutre H, eds), Academic Press, ISBN 0124159753, Mason HS, Thuenemann E, Kiyono H, Kessans S, Matoba N, Mor T. Mucosal Immunology 4th Ed.. Chapter 66: Mucosal vaccines from plant biotechnology (2013) Book Chapters.

2012

  • Miller T, Fanton M, Nickelson S, Mason H, Webb S. Safety and immunogenicity of bacterial and tobacco plant cell line derived recombinant native and mutant Escherichia coli heat-labile toxin in chickens. Avian Pathol. (2012) Refereed Articles.
  • P. Kozlowski, ed., Mason HS, Herbst-Kralovetz MM. Current Topics in Microbiology and Immunology , Mucosal Vaccines: Modern Concepts, Strategies, and Challenges. Plant-derived antigens as mucosal vaccines (2012) Book Chapters.
  • Rattanapisit K, Bhoo SH, Hahn TR, Mason HS, Phoolcharoen W. Rapid transient expression of cholera toxin B subunit (CTB) in Nicotiana benthamiana. In Vitro Cell. Devel. Biol.  Plant (2012) Refereed Articles.

2011

  • Chen Q, He J, Phoolcharoen W, Mason HS. Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Human Vaccines (2011) Refereed Articles.
  • Chen Q, He J, Phoolcharoen W, Mason HS. Geminiviral vectors based on bean yellow dwarf virus for production of vaccine antigens and monoclonal antibodies in plants. Human Vaccines (2011) Refereed Articles.
  • Mathew LG, Maloney B, Takeda N, Mason HS. Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants. Plant Mol Biol. (2011) Refereed Articles.
  • Mathew LG, Maloney B, Takeda N, Mason HS. Spurious polyadenylation of Norovirus Narita 104 capsid protein mRNA in transgenic plants. Plant Mol Biol. (2011) Refereed Articles.
  • Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS. Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol. J. (2011) Refereed Articles.
  • Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS. Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana. Plant Biotechnol. J. (2011) Refereed Articles.
  • Phoolcharoen W, Dye JM, Kilbourne J, Piensook K, Pratt WD, Arntzen CJ, Chen Q, Mason HS, Herbst-Kralovetz MM. A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge. Proc. Natl. Acad. Sci. USA (2011) Refereed Articles.
  • Pinkhasov J, Alvarez ML, Rigano MM, Piensook K, Larios D, Pabst M, Grass J, Mukherjee P, Gendler SJ, Walmsley AM, Mason HS. Recombinant plant-expressed tumor-associated MUC1 peptide is immunogenic and capable of breaking tolerance in MUC1.Tg mice. Plant Biotechnol. J. (2011) Refereed Articles.

2010

  • D. Heldman, A. Bridges, D.G. Hoover, and M. Wheeler, eds., Santi L, Mason HS. Encyclopedia of Biotechnology in Agriculture and Food. Plants as biofactories for vaccine production (2010) Book Chapters.
  • Daskalova SM, Radder JE, Cichacz ZA, Olsen SH, Tsaprailis G, Mason H, Lopez LC. Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins--towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation. BMC Biotechnol. (2010) Refereed Articles.
  • Herbst-Kralovetz M, Mason HS (corresponding author), Chen Q. Norwalk virus-like particles as vacines. Expert Rev. Vaccines (2010) Refereed Articles.
  • Herbst-Kralovetz M, Mason HS (corresponding author), Chen Q. Norwalk virus-like particles as vacines.. Expert Rev. Vaccines (2010) Refereed Articles.
  • Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, *Mason HS, *Chen Q. High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol. Bioeng. (2010) Refereed Articles.
  • Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, *Mason HS, *Chen Q (*co-corresponding authors). High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system. Biotechnol. Bioeng. (2010) Refereed Articles.
  • Kozlowski, P, Mason, HS; Herbst-Kralovetz, M. Current Topics in Microbiology and Immunology, Vol on Mucosal Vaccines: Modern Concepts, Strategies, and Challenges. Plant-derived Antigens as Mucosal Vaccines (2010) Book Chapters.
  • Martinez CA, Topal E, Giulietti AM, Talou JR, Mason HS. Exploring different strategies to express Dengue virus envelope protein in a plant system. Biotechnol. Lett. (2010) Refereed Articles.
  • Pinkhasov J, Alvarez ML, Pathangey LB, Tinder TL, Mason HS, Walmsley AM, Gendler SJ, Mukherjee P. Analysis of a cholera toxin B subunit (CTB) and human mucin 1 (MUC1) conjugate protein in a MUC1-tolerant mouse model. Cancer Immunol Immunother (2010) Refereed Articles.

2009

  • Del Prete G, Santi L, Andrianaivoarimanana V, Amedei A, Domarle O, D' Elios MM, Arntzen CJ, Rahalison L, Mason HS. Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system. Int J Immunopathol Pharmacol (2009) Refereed Articles.
  • Huang Z, Chen Q, Hjelm B, Arntzen C, Mason H. A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol Bioeng (2009) Refereed Articles.
  • Huang Z, Chen Q, Hjelm B, Arntzen C, Mason H. A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnol. Bioeng. (2009) Refereed Articles.
  • Webster DE, Wang L, Mulcair M, Ma C, Santi L, Mason HS, Wesselingh SL, Coppel RL. Production and characterisation of an orally immunogenic Plasmodium antigen in plants using a virus-based expression system. Plant Biotechnol. J. (2009) Refereed Articles.

2008

  • Huang Z, LePore K, Elkin G, Thanavala Y, Mason HS. High-yield rapid production of hepatitis B surface antigen in plant leaf by a viral expression system. Plant Biotechnol. J. (2008) Refereed Articles.
  • Luca Santi, Lance Batchelor, Zhong Huang, Brooke Hjelm, Jacquelyn Kilbourne, Charles Arntzen, Qiang Chen, Hugh Mason. An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles. Vaccine (2008) Refereed Articles.

2007

  • Heldman, Dennis, Bridges, Anne, Hoover, Dallas, Wheeler, Matthew, Santi, L,Mason, Hugh S (Author). Encyclopedia of Biotechnology in Agriculture and Food. Vaccines Produced in Transgenic Plants (2007) Book Chapters.
  • J Van Eck, B Conlin, D Garvin, Hugh Mason, D Navarre, C Brown. Enhancing [[beta]]-carotene content in potato by RNAi-mediated silencing of the [[beta]]-carotene hydroxylase gene. Ame J Potato Res (2007) Refereed Articles.
  • Jason Collens, Hugh Mason, Wayne Curtis. Agrobacterium-mediated viral vector-amplified transient gene expression in Nicotiana glutinosa plant tissue culture. Biotechnol Prog (2007) Refereed Articles.
  • Santi, L, Mason, Hugh S. Vaccines Produced in Transgenic Plants. Encyclopedia of Biotechnology in Agriculture and Food (2007) Encyclopedia Articles.

2006

  • A Becerra-Arteaga, Hugh Mason, M Shuler. Production, Secretion, and Stability of Human Secreted Alkaline Phosphatase in Tobacco NT1 Cell Suspension Cultures. Biotechnol. Prog (2006) Refereed Articles.
  • K Mayo, B Gonazales, Hugh Mason. Genetic transformation of tobacco NT1 cells with Agrobacterium tumefaciens. Nature Protocols (2006) Refereed Articles.
  • L Santi, A Giritch, C Roy, S Marillonnet, V Klimyuk, Y Gleba, R Webb, C Arntzen, Hugh Mason. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc. Natl. Acad. Sci. USA (2006) Refereed Articles.
  • L Santi, Z Huang, Hugh Mason. Virus-like particles production in green plants. Methods (2006) Refereed Articles.
  • M Alvarez, H Pinyerd, J Crisantes, M Rigano, J Pinkhasov, A Walmsley, Hugh Mason, Guy Cardineau. Plant-made subunit vaccine against pneumonic and bubonic plague is orally immunogenic in mice. Vaccine (2006) Refereed Articles.
  • S Saldaña, L Richter, C Arntzen, M Gómez-Lim, F Guadarrama, T de Jesus Olivera Flores, N Arias, S López, C Arias, R Ruiz, Hugh Mason, T Mor. Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol (2006) Refereed Articles.
  • X Zhang, Hugh Mason. Bean yellow dwarf virus replicons for high-level transgene expression in transgenic plants and cell cultures. Biotechnol Bioeng (2006) Refereed Articles.
  • X Zhang, N Buehner, A Hutson, M Estes, Hugh Mason. Tomato is a highly effective vehicle for expression and oral immunization with Norwalk virus capsid protein. Plant Biotechnol. J (2006) Refereed Articles.
  • Zhong Huang, L Santi, K LePore, J Kilbourne, C Arntzen, Hugh Mason. Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine (2006) Refereed Articles.

2005

  • C Arntzen, R Mahoney, Hugh Mason, D Kirk. Oral Vaccines Derived from Transgenic Plants. Vaccines: Preventing disease and protecting health (2005) Refereed Articles.
  • C Mihalek, J Van Eck, S Webb, T Miller, M Fanton, D Kirk, G Cardineau, Hugh Mason, A Walmsley, A Artnzen. Development of plant cell produced vaccines for animal health applications. Proc. Ann. Meeting U.S. Animal Health Assoc (2005) Refereed Articles.
  • J Bryan, B Maloney, Naokazu Takeda, Yuriko Suzaki, Ami Yasushi, Tian Li, Tatsuo Miyamura, Charles Arntzen, Hugh Mason. Challenges in creating a vaccine to prevent hepatitis E. Vaccine (2005) Refereed Articles.
  • Y Thanavala, M Mahoney, S Pal, A Scott, L Richter, N Natarajan, P Goodwin, C Arntzen, Hugh Mason. Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci. USA (2005) Refereed Articles.
  • Zhong Huang, G Elkin, B Maloney, N Beuhner, C Arntzen, Y Thanavala, Hugh Mason. Virus-like particle expression and assembly in plants: hepatitis B and Norwalk viruses. Vaccine (2005) Refereed Articles.

2004

  • Christou, P, Klee, H, Mor, T S (Author) ,Mason, Hugh S (Author). Handbook of Plant Physiology. Plants as a source for subunit vaccines (2004) Book Chapters.
  • Levine, Myron M, Kaper, James B, Rappuoli, Rino, Liu, Margaret A, Mor, T S (Author) ,Mason, Hugh S (Author) ,Kirk, D (Author) ,Arntzen, C J (Author) ,Cardineau, G A (Author). New Generation Vaccines, Third Edition. Plants as a delivery vehicle for orally delivered subunit vaccines (2004) Book Chapters.
  • Mason, Hugh S. Vaccines produced in transgenic plants. Encyclopedia of Plant and Crop Science (2004) Encyclopedia Articles.
  • McGhee, J R, Mestecky, J F, Mason, Hugh S (Author) ,Chikwamba, R (Author) ,Santi, L (Author) ,Mahoney, R T (Author) ,Arntzen, C J (Author). Mucosal Immunology, 3rd Edition. Section D. Mucosal Vaccines. Antigen delivery systems: Transgenic plants for mucosal vaccines (2004) Book Chapters.
  • N Judge, Hugh Mason, A O'Brien. Plant cell-based intimin vaccine given orally to mice primed with intimin reduces time of Escherichia coli O157:H7 shedding in feces. Infect. Immun (2004) Refereed Articles.
  • Z Huang, Hugh Mason. Conformational analysis of hepatitis B surface antigen fusions in an Agrobacterium-mediated transient expression system. Plant Biotechnol. J (2004) Refereed Articles.

2003

  • A Walmsley, D Kirk, Hugh Mason. Passive immunization of mice pups through oral immunization of dams with a plant-derived vaccine. Immunology Letters (2003) Refereed Articles.
  • A Walmsley, M Alvarez, Y Jin, D Kirk, S Lee, J Pinkhasov, M Rigano, C Arntzen, Hugh Mason. Expression of the B subunit of Escherichia coli heat-labile enterotoxin as a fusion protein in transgenic tomato. Plant Cell Reports (2003) Refereed Articles.
  • H Warzecha, Hugh Mason. Benefits and risks of antibody and vaccine production in transgenic plants. J. Plant Physiol (2003) Refereed Articles.
  • H Warzecha, Hugh Mason, C Lane, A Tryggvesson, E Rybicki, A Williamson, J Clements, R Rose. Oral immunogenicity of human papillomavirus-like particles expressed in potato. Journal of Virology (2003) Refereed Articles.
  • K Palmer, T Mor, Y Moon, Hugh Mason. Geminivirus vectors for high level expression of foreign proteins in plant cells. Biotechnology & Bioengineering (2003) Refereed Articles.
  • M Smith, L Richter, C Arntzen, M Shuler, Hugh Mason. Structural characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine (2003) Refereed Articles.
  • P Sojikul, N Buehner, Hugh Mason. A plant signal peptide-hepatitis B surface antigen fusion protein with enhanced stability and immunogenicity expressed in plant cells. Proc. Natl. Acad. Sci. USA (2003) Refereed Articles.
  • R Chikwamba, M Scott, L Mejia, Hugh Mason, K Wang. Localization of a bacterial protein in starch granules of transgenic maize kernels. Proc. Natl. Acad. Sci. USA (2003) Refereed Articles.
  • T Mor, Hugh Mason. Plants as a source for subunit vaccines. Handbook of Plant Physiology (Christou P, Klee H, Eds.) John Wiley & Sons (2003) Nonrefereed Articles.

2002

  • Hugh Mason. Plant-based vaccines: Expression and oral immunogenicity. Vitro Cell. Devel. Biol. - Plant (2002) Refereed Articles.
  • Hugh Mason, H Mason, M Shuler. Hepatitis B surface antigen (HBsAg) expression in plant cell culture; the kinetics of antigen accumulation in batch culture and its intracellular form. Biotechnol. Bioeng (2002) Refereed Articles.
  • Hugh Mason, H Warzecha, Tsafrir Mor, C Arntzen. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. Trends Mol. Med (2002) Refereed Articles.
  • J Cao, H Ibrahim, J Garcia, Hugh Mason, R Granados, E Earle. Transgenic tobacco plants carrying a baculovirus enhancin gene slow development and enhance mortality of Trichoplusia ni larvae. Plant Cell Rep (2002) Refereed Articles.
  • M Smith, M Keegan, Hugh Mason, M Shuler. Factors important in the extraction, stability and in vitro assembly of the hepatitis B surface antigen derived from recombinant plant systems. Biotechnol. Prog (2002) Refereed Articles.
  • R Chikwamba, J Cunnick, D Hathaway, J McMurray, Hugh Mason, K Wang. A functional antigen in a practical crop: Maize synthesized LT-B protects mice against Escherichia coli heat labile enterotoxin (LT) and cholera toxin (CT). Transgenic Research (2002) Refereed Articles.
  • R Chikwamba, J McMurray, B Frame, P Scott, Hugh Mason, K Wang. Expression of a bacterial antigen in maize: The role of regulatory sequences, inheritance and level of expression of the synthetic E. coli heat labile toxin B sub-unit (LT-B) in maize. Molecular Breeding (2002) Refereed Articles.

2001

  • C Arntzen, L Richter, Q Kong, Y Thanavala, Y Yang, Hugh Mason. Oral immunization with hepatitis B surface antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. USA (2001) Refereed Articles.
  • T Mor, M Sternfeld, H Soreq, C Arntzen, Hugh Mason. Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotechnol. Bioeng (2001) Refereed Articles.

2000

  • B Dogan, Hugh Mason, L Richter, J Hunter, M Shuler. Process options in hepatitis B surface antigen extraction from transgenic potato. Biotechnol. Progress (2000) Refereed Articles.
  • C Tacket, Hugh Mason, G Losonsky, M Estes, M Levine, C Arntzen. Human immune responses to a novel Norwalk virus vaccine delivered in transgenic potatoes. J. Infect. Dis (2000) Refereed Articles.
  • L Richter, Y Thanavala, C Arntzen, Hugh Mason. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnol (2000) Refereed Articles.