Publications

Open access to ‘The Origins of Cellular Architecture’

We have taken on one of the last uncharted fields in evolution: integrating evolutionary biology with cell biology. This sequel to The Origins of Genome Architecture brings evolutionary theory to bear on a diversity of observations on the functional and structural features of cells.


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2024

Brettner, L., Eder, R., Schmidlin, K., & Geiler‐Samerotte, K. (2024). An ultra high‐throughput, massively multiplexable, single‐cell RNA‐seq platform in yeasts. Yeast, 41(4), 242-255.

https://doi.org/10.1002/yea.3927.

Research article.

Butenko, A., Lukeš, J., Speijer, D., & Wideman, J. G. (2024). Mitochondrial genomes revisited: why do different lineages retain different genes?. BMC biology22(1), 15.

https://doi.org/10.1186/s12915-024-01824-1.

Research article.

Padilla, L. F. A., Murray, J. M., & Hu, K. (2024). The initiation and early development of the tubulin-containing cytoskeleton in the human parasite Toxoplasma gondii. Molecular Biology of the Cell35(3), ar37.

https://doi.org/10.1091/mbc.E23-11-0418.

Research article.

Schmidlin, Apodaca, Newell, Sastokas, & Kinsler. (2024). Distinguishing mutants that resist drugs via different mechanisms by examining fitness tradeoffs across hundreds of fluconazole-resistant yeast strains. eLife, 13, RP94144.

https://doi.org/10.7554/eLife.94144.1.

Research article.


2023

Chung, C., Verheijen, B. M., Zhang, X., Huang, B., Coakley, A., McGann, E., Wade, E., Dinep-Schneider, O., LaGosh, J., Anagnostou, M.-E., Simpson, S., Thomas, K., Ernst, M., Rattray, A., Lynch, M., Kashlev, M., Benayoun, B. A., Li, Z., Strathern, J., … Vermulst, M. (2023). The fidelity of transcription in human cells. Proceedings of the National Academy of Sciences, 120(5).

https://doi.org/10.1073/pnas.2210038120.

Research article.

Devi, A., Speyer, G., & Lynch, M. (2023). The divergence of mean phenotypes under persistent directional selection. Genetics224(3), iyad091.

https://doi.org/10.1093/genetics/iyad091.

Research article.

Geiler-Samerotte, K., & Lang, G. I. (2023). Best Practices in Microbial Experimental Evolution. Journal of Molecular Evolution91(3), 237-240.

https://doi.org/10.1007/s00239-023-10119-y.

Research article.

Gout, J. F., Hao, Y., Johri, P., Arnaiz, O., Doak, T. G., Bhullar, S., … & Lynch, M. (2023). Dynamics of gene loss following ancient whole-genome duplication in the cryptic Paramecium complex. Molecular biology and evolution40(5), msad107.

https://doi.org/10.1093/molbev/msad107.

Research article.

Hoelzel, A. R., & Lynch, M. (2023). The raw material of evolution. Science381(6661), 942-943.

https://doi.org/10.1126/science.adk0121.

Research article.

Kinsler, G., Schmidlin, K., Newell, D., Eder, R., Apodaca, S., Lam, G., … & Geiler-Samerotte, K. (2023). Extreme sensitivity of fitness to environmental conditions: Lessons from# 1BigBatch. Journal of Molecular Evolution91(3), 293-310.

https://doi.org/10.1007/s00239-023-10114-3.

Research article.

Kucukyildirim, S., Ozdemirel, H. O., & Lynch, M. (2023). Similar mutation rates but different mutation spectra in moderate and extremely halophilic archaea. G3: Genes, Genomes, Genetics13(3), jkac303.

https://doi.org/10.1093/g3journal/jkac303.

Research article.

Kumar, A., Gok, M. O., Nguyen, K. N., Reese, M. L., Wideman, J. G., Muñoz-Gómez, S. A., & Friedman, J. R. (2023). A DRP-like pseudoenzyme coordinates with MICOS to promote cristae architecture. bioRxiv.

https://doi.org/10.1101%2F2023.10.03.560745.

Research article.

Li, W., Baehr, S., Marasco, M., Reyes, L., Brister, D., Pikaard, C. S., … & Lynch, M. (2023). A Narrow Range of Transcript-error Rates Across the Tree of Life. bioRxiv, 2023-05.

https://doi.org/10.1101/2023.05.02.538944.

Research article.

Long, H., Johri, P., Gout, J. F., Ni, J., Hao, Y., Licknack, T., … & Lynch, M. (2023). Paramecium Genetics, Genomics, and Evolution. Annual review of genetics57, 391-410.

https://doi.org/10.1146/annurev-genet-071819-104035.

Research article.

Lynch M. (2023). Mutation pressure, drift, and the pace of molecular coevolution. Proceedings of the National Academy of Sciences of the United States of America120(27), e2306741120.

https://doi.org/10.1073/pnas.2306741120.

Research article.

Lynch, M., Ali, F., Lin, T., Wang, Y., Ni, J., & Long, H. (2023). The divergence of mutation rates and spectra across the Tree of Life. EMBO reports24(10), e57561.

https://doi.org/10.15252/embr.202357561.

Research article.

Macher, J. N., Coots, N. L., Poh, Y. P., Girard, E. B., Langerak, A., Muñoz-Gómez, S. A., … & Wideman, J. G. (2023). Single-cell genomics reveals the divergent mitochondrial genomes of Retaria (Foraminifera and Radiolaria). Mbio14(2), e00302-23.

https://doi.org/10.1128/mbio.00302-23.

Research article.

Moger-Reischer, R. Z., Glass, J. I., Wise, K. S., Sun, L., Bittencourt, D. D. C., Lehmkuhl, B. K., … & Lennon, J. T. (2023). Evolution of a minimal cell. Nature620(7972), 122-127.

https://doi.org/10.1038/s41586-023-06288-x.

Research article.

Ni, J., Pan, J., Wang, Y., Chen, T., Feng, X., Li, Y., … & Li, W. (2023). An integrative protocol for one-step PCR amplicon library construction and accurate demultiplexing of pooled sequencing data. Marine Life Science & Technology5(4), 564-572.

https://doi.org/10.1007/s42995-023-00182-1.

Research article.

Quan, N., Eguchi, Y., & Geiler-Samerotte, K. (2023). Intra-FCY1: a novel system to identify mutations that cause protein misfolding. Frontiers in Genetics14, 1198203.

https://doi.org/10.3389/fgene.2023.1198203.

Research article.

Singh, R. P., Poh, Y. P., Sinha, S. D., & Wideman, J. G. (2023). Evolutionary History of Oxysterol-Binding Proteins Reveals Complex History of Duplication and Loss in Animals and Fungi. Contact6, 25152564221150428.

https://doi.org/10.1177/25152564221150428.

Research article.

Sinha, S. D., & Wideman, J. G. (2023). The persistent homology of mitochondrial ATP synthases. Iscience26(5).

https://doi.org/10.1016/ j.isci.2023.106700.

Research article.

Sterner, B., Elliott, S., & Wideman, J. G. (2023). An account of conserved functions and how biologists use them to integrate cell and evolutionary biology. Biology & Philosophy38(5), 45.

https://doi.org/10.1007/s10539-023-09933-x.

Research article.

Suvorov, V., Saakian, D. B., & Lynch, M. (2023). A solution of the Crow-Kimura evolution model on fluctuating fitness landscape. Europhysics Letters142(5), 57003.

https://doi.org/10.1209/0295-5075/acd65b.

Research article.


2022

Kucukyildirim, S., Ozdemirel, H. O., & Lynch, M. (2022). Similar mutation rates but different mutation spectra in moderate and extremely halophilic archaea. G3 Genes|Genomes|Genetics, 13(3).

https://doi.org/10.1093/g3journal/jkac303.

Journal article.

Lynch, M., Schavemaker, P. E., Licknack, T. J., Hao, Y., & Pezzano, A. (2022). Evolutionary Bioenergetics of ciliates. Journal of Eukaryotic Microbiology, 69(5).

https://doi.org/10.1111/jeu.12934.

Review article.

Lynch, M., Trickovic, B., & Kempes, C. P. (2022). Evolutionary scaling of maximum growth rate with organism size. Scientific Reports, 12(1).

https://doi.org/10.1038/s41598-022-23626-7.

Journal article.

Schavemaker, P. E., & Lynch, M. (2022). Flagellar energy costs across the Tree of Life. eLife, 11.

https://doi.org/10.7554/eLife.77266.

Research article.

Brettner, L., Ho, W. C., Schmidlin, K., Apodaca, S., Eder, R., & Geiler-Samerotte, K. (2022). Challenges and potential solutions for studying the genetic and phenotypic architecture of adaptation in microbes. Current opinion in genetics & development75, 101951.

https://doi.org/10.1016/j.gde.2022.101951.

Research article.

Frasch, W. D., Bukhari, Z. A., & Yanagisawa, S. (2022). F1FO ATP synthase molecular motor mechanisms. Frontiers in microbiology13, 965620.

https://doi.org/10.3389/fmicb.2022.965620.

Research article.

Harrison, J. F., Biewener, A., Bernhardt, J. R., Burger, J. R., Brown, J. H., Coto, Z. N., … & Williams, T. M. (2022). White paper: an integrated perspective on the causes of hypometric metabolic scaling in animals. Integrative and Comparative Biology62(5), 1395-1418.

https://doi.org/10.1093/icb/icac136.

Research article.

Johri, P., Aquadro, C. F., Beaumont, M., Charlesworth, B., Excoffier, L., Eyre-Walker, A., … & Jensen, J. D. (2022). Recommendations for improving statistical inference in population genomics. PLoS biology20(5), e3001669.

https://doi.org/10.1371/journal.pbio.3001669.

Research article.

Johri, P., Gout, J. F., Doak, T. G., & Lynch, M. (2022). A population-genetic lens into the process of gene loss following whole-genome duplication. Molecular biology and evolution39(6), msac118.

https://doi.org/10.1093/molbev/msac118.

Research article.

Lynch, M., Trickovic, B., & Kempes, C. P. (2022). Evolutionary scaling of maximum growth rate with organism size. Scientific reports12(1), 22586.

https://doi.org/10.1038/s41598-022-23626-7.

Research article.

Pan, J., Li, W., Ni, J., Wu, K., Konigsberg, I., Rivera, C. E., … & Long, H. (2022). Rates of mutations and transcript errors in the foodborne pathogen Salmonella enterica subsp. enterica. Molecular biology and evolution39(4), msac081.

https://doi.org/10.1093/molbev/msac081.

Research article.

Richter, D. J., Berney, C., Strassert, J. F., Poh, Y. P., Herman, E. K., Muñoz-Gómez, S. A., … & de Vargas, C. (2022). EukProt: a database of genome-scale predicted proteins across the diversity of eukaryotes. Peer Community Journal2.

https://doi.org/10.24072/pcjournal.173.

Research article.


2021

Yanagisawa, S., & Frasch, W. D. (2021). pH-dependent 11 F1FO ATP synthase sub-steps reveal insight into the FO torque generating mechanism. Elife10, e70016.

https://doi.org/10.7554/eLife.70016.

Research article.


Showing 37 Results