Research

Research interests

Chang is an immunologist who studies the development and function of the immune system. She and her research team investigate the genetic recombination process that is crucial to the establishment of adaptive immunity — the immune response the body makes to specific invaders. They also investigate how alterations of this genetic process can lead to immunodeficiencies and cancers of lymphoid cells.

In addition, Dr. Chang and her collaborators have developed a new methodology to modulate immune responses. Specifically, they use DNA nanotechnology to design and construct more useful vaccines and immunotherapeutic agents. They also investigate other nanomaterials, focusing on the environmental impact of these synthetics and their adverse effect on aquatic organisms.

Research activity

  1. Chang,Yung * , Hecht,Sidney Michael , Kumar,Sudhir , Yan,Hao , . Rational design and targeted selection of effective DNA-scaffolded nicotine vaccines (Chang). HHS-NIH-NIDA (4/15/2013 - 2/29/2016).
  2. Chang,Yung * . Anti-tumor Immunomodulating DNA-nanostructures. ASU-Mayo Seed Grant (1/1/2012 - 12/31/2012).
  3. Duch,Carsten Juergen * , Chang,Yung , Hogue,Brenda G , Jung,Ranu , Kusumi,Kenro , Neisewander,Janet Leigh , Newfeld,Stuart J ,Smith,Brian , . Acquisition of a Leica TCS SP5 Laser Scanning Confocal Microscope. HHS-NIH-NCRR (5/1/2011 - 4/30/2012).
  4. Chang,Yung * Hecht,Sidney Michael Yan,Hao . TURNABLE NICOTINE DNA-NANOVACCINES. HHS-NIH-NIDA (4/1/2011 - 3/31/2014).
  5. Chang,Yung * Liu,Yan Yan,Hao . Tunable DNA-nanostructure to Induce NK-mediated Killing of Tumor Cells. HHS-NIH-NCI (5/1/2010 - 4/30/2013).
  6. Chang,Yung * . Overcoming Drug Resitance in Breast Cancer Stem Cells (BCSC). MAYO CLINIC SCOTTSDALE (1/1/2010 - 12/31/2010).
  7. Chang,Yung * Liu,Yan Yan,Hao . Multi-Specific aptamer-nanoscaffolds to induce aptamer-dependent cellular cytotoxicity (ApDCC) against breast cancer cells. DOD-ARMY-USAMRAA (9/15/2009 - 1/14/2011).
  8. Chen,Julian J-L * Chen,Julian J-L * Chang,Yung . Development fo a fish model for dyskeratosis congenita and cancer research. HHS-NIH-NCRR (9/15/2008 - 6/30/2010).
  9. Jacobs,Bertram Lewis * Chang,Yung . Disabling Vaccinia IFNr: A New Smallpox Vaccine. HHS-NIH-NIAID (7/1/2008 - 12/31/2010).
  10. Chang,Yung * . Novel Cellular Model to Study Chromosome Abnormality. MAYO CLINIC SCOTTSDALE (1/1/2008 - 12/31/2009).
  11. Jacobs,Bertram Lewis * Chang,Yung . Disabling Vaccinia IFNr: A New Smallpox Vaccine. HHS-NIH-NIAID (7/1/2007 - 6/30/2010).
  12. Chang,Yung * . Surface Phenotyping ofEndotheliz Progenitors Isolated from PBL. VA-Hayden Center (7/1/2007 - 6/30/2008).
  13. Chen,Yongsheng * Chang,Yung Hu,Qiang Sommerfeld,Milton R . Methodology Development for Manufactured Nanomaterial Bioaccumulation Test. USEPA-REGION 9 (5/1/2007 - 4/30/2010).
  14. Jacobs,Bertram Lewis * Chang,Yung . Disabling Vaccinia IFNr: A New Smallpox Vaccine. HHS-NIH-NIAID (7/1/2006 - 6/30/2009).
  15. Petuskey,William T * , Chang,Yung , Daniel,Douglas , Fromme,Petra , Gould,Ian R , Gust,John Devens , Lin,Su , Liu,Yan , Moore,Ana L ,Moore,Thomas Andrew , Roberson,Robert Wayne , Vermaas,Willem F J , Wachter,Rebekka M , Webber,Andrew Neil , Wei,Qihuo ,Woodbury,Neal Walter , Yan,Hao , Zenhausern,Frederic , Zenhausern,Frederic , . Purchase of an Instrument for Ultrafast, Multidimensional Fluorescence Detection and Imaging. NSF-MPS-CHE (2/15/2006 - 1/31/2009).
  16. Jacobs,Bertram Lewis * Chang,Yung . Disabling Vaccinia IFNr: A New Smallpox Vaccine. HHS-NIH-NIAID (7/10/2005 - 6/30/2006).
  17. Chang,Yung * Brophy,Colleen M Jacobs,Bertram Lewis Misra,Rajeev Pettit,George Robert Sierks,Michael Richard Zautra,Alex John . THE BD FACSARIA, A NEW FLOW CYTOMETER SORTER. HHS-NIH-NCRR (4/1/2004 - 3/31/2005).
  18. Chang,Yung * . NICOTINE REGULATION OF T CELL DEVELOPMENT. UNIV OF AZ (9/30/2003 - 1/31/2008).
  19. Chang,Yung * . EVALUATION OF ECHINACEA: ITS TOXICITY AND IMMUNE MODULATION. GAIA HERBS (1/2/2003 - 12/31/2005).
  20. Schmidt,Jean M * Chang,Yung . IN VIVO EFFICACY EVALUATION OF NEW ANTICANCER DRUGS. ABRC (7/1/2002 - 6/30/2003).
  21. Schmidt,Jean M * Chang,Yung . IN VIVO EFFICACY EVALUATION OF NEW ANTICANCER DRUGS. ABRC (7/1/2001 - 6/30/2002).
  22. Schmidt,Jean M * Chang,Yung . IN VIVO EFFICACY EVALUATION OF NEW ANTICANCER DRUGS. ABRC (7/1/2000 - 6/30/2001).
  23. Chang,Yung * . MICROFLUIDS DEVISE FOR DIAGNOSIS OF NOSOCOMIAL AGENTS. MOTOROLA, INC (11/1/1999 - 10/31/2002).
  24. Chang,Yung * . EFFECT OF VDJ RECOMBINATION ON SCID B CELL DEVELOPMENT. HHS-NIH-NCI (9/1/1998 - 12/31/2009).
  25. Chang,Yung * . DNA CHIP DEVELOPMENT. MOTOROLA, INC (7/1/1997 - 6/30/2004).

* principal investigator