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  1.  Qi, X., X. Liu, L. Matiski, R. Rodriguez Del Villar, F. Zhang, S. Sokalingam, S. Jiang, H. Liu, Li, Yan, Hao; Y. Chang*,. 2020. RNA origami nanostructures for potent and safe anti-cancer immunotherapy. ACS Nano. 14: 4727-4740.


  1.  Li, S., Jiang, Q., Liu S., Zhang, Y., Tian, Y., Song, C., Wang, J., Zou, Y., Anderson, G. J., Han, J-Y, Chang, Y., Liu, Y. Zhang, C., Chen, L., Zhou, G., Nie, G., Yan, H., Ding, B., & Zhao Y. 2018. A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Nat. Biotechnol. 36: 258-264.


  1. Arutla, V., J. Leal, X. Liu, S. Sokalingam, M. Raleigh, A. Adaralegbe, L. Liu, P. R. Pentel, S. M. Hecht & Y. Chang*. 2017. Pre-screening of nicotine hapten linkers in vitro to select hapten-conjugate vaccine candidates for pharmacokinetic evaluation in vivo. ACS Combinatory Science. 19(5):286-298.


  1. Liu, L. Y. Chang, T. Yang, D. P. Noren, B. Long, S. Kornblau, A. Autub & J. Ye. 2016. Evolution-informed modeling improves outcome prediction for cancers. Evol. Appl. 10:68-76.
  2. Liu, X., L. Wang, H. Yan & Y. Chang*. 2016. Assembly and assessment of DNA scaffolded vaccines. Methods and Protocol: Volume 1: Vaccines for human diseases. Edited by Thomas, S.


  1. Kasuen Kotagama, Yung Chang, Marco Mangone miRNAs as Biomarkers in Chronic Myelogenous Leukemia Drug Dev Res. Author manuscript; available in PMC 2016 March 3.
    Published in final edited form as: Drug Dev Res. 2015 September; 76(6): 278–285. Published online 2015 August 18. doi: 10.1002/ddr.21266
  2. Sunil Thomas, Xiaowei Liu, Hao Yan and Yung Chang. Vaccine Design: Methods and Protocols. DNA-assembled vaccines (2015) Book Chapters.


  1. Liu., X., Y. Xu, T. Yu, C. Clifford, Y. Liu, H. Yan* & Y. Chang*. 2012. A DNA nanostructure platform for directed assembly of synthetic vaccines. Nano Letters (accepted for publication).
  2. Wang, J., X. Zhu, X. Y. Chen* and Y. Chang*. 2012. The application of embryonic and adult zebrafish for assessing nanotoxicology. In Nanotoxicity: Methods and Protocols. Editor: J. J. Reineke. Human Press 2012 (In Press).
  3. Wang, G., K. Dhar, P. C. Swanson, M. Levitus* & Y. Chang*. 2012. Real time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the post-cleavage complex. Nucl. Acid Res. (in press).


  1. Liu, X., H. Yan, Y. Liu* & Y. Chang*. 2011. Targeted Cell-Cell Interactions by DNA Nanoscaffold-Templated Multivalent Bi-specific Aptamers. Small. 7:1673-1682.
  2. Wang, J, X. Zhu, X. Zhang, Z. Zhao, H. Liu, R. George, J. Wilson-Rawls. Y. Chang* and Y. Chen*. 2011. Are TiO2 nanoparticles safe? Disruption of zebrafish (Danio reior) reproduction upon chronic exposure to low concentrations of TiO2 nanoparticles. Chemosphere. 83:461-467.


  1. Zhu, X., Y. Chang* & Y. Chen. 2010. Toxicity and bioaccumulation of TiO2 nanoparticle aggregates in Daphnia magna. Chemosphere. 78:209-215.
  2. Zhu, X, J. Wang, Y*. Zhang, Y. Chang* & Y. Chen*. 2010. Trophic transfer of TiO2 nanoparticles from Daphina to zebrafish in a simplified freshwater food chain. Chemosphere. 79: 928-933.


  1. Franco, D. & Y. Chang. 2009. Accessibility of Chromosomal Recombination Breaks in Nuclei of Wild-type and DNA-PKcs-Deficient cells. DNA Repair. 8: 813-821.
  2. Zhu, X., J. Wang, X. Zhang, Y. Chang* & Y. Chen. 2009. Impact of ZnO nanoparticle aggregates on the embryonic development of Zebrafish (Danio rerio). Nanotechology. 20: 195103 (1-9).
  3. Hahn, K. L., B. Beres, M. Rowton, M. Skinner, Y. Chang, A. Rawls, J. Wilson-Rawls. 2009. A deficiency of Lunatic fringe is associated with defects of the rete testis. Reproduction. 137: 79-93.


  1. Zhao, Z.  J. Wang, H. Liu, J. Ye & Y. Chang. 2008. Identifying biologically relevant genes via multiple heterogeneous data sources. KDD 2008: 839-847.
  2. Pavlicek, J, Y. Lyubchenko and Y. Chang. 2008. Revelation of RAG-induced DNA bending by atomic force microscopy. Biochemistry. 47:11204-11.Jentarra, GM, M.C. Heck, J.W. Youn, K. Kibler, J.O. Langland, C. R. Baskin, O. Ananieva, Y. Chang & Jacobs BL. 2008. Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination. Vaccine. 26:2860-72.
  3. Ke, Y., S. Lindsay, Y. Chang, Y. Liu and H. Yan. 2008. Self-assembled Water-soluble Nanoarrays for Label Free RNA Hybridization Assays. Science 319:180-183.


  1. Wang, Q., Y. Xu, X. Zhao, Y. Chang, Y. Liu, L. Jiang, J. Sharma, D. K. Seo & H. Yan. 2007. A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation. J. Am. Chem. Soc., 129:6380-6381.
  2. Li, Z., Y. Chang. 2007. V(D)J recombination in zebrafish: normal joining products with accumulation of unresolved coding ends and deleted signal ends. Mol. Immunol. 44:1804-1813.
  3. Zhong, H., Z. Li, S. Lin and Y. Chang. 2007. Initiation of V(D)J recombination in zebrafish (Danio rerio) ovaries. Mol. Immunol. 44:1795-1803.


  1. Jacobsen, E. O. Ananieva, M. L. Brown and Y. Chang. 2006. Growth, differentiation and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene. J. Immunol. 176:6831-6838.
  2. Bogani, F. E. McConnell, L. Joshi, Y. Chang, G. Ghirlanda. 2006. A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. J. Am. Chem. Soc. 128:7142-7143.

* Co-corresponding author