Associate Professor, Biodesign Center for Immunotherapy, Vaccines and Virotherapy
Yixin Shi studies the genetic analysis of virulent determinants essential for bacterial survival in host environments, homeostasis of metal ions in enteric bacteria, and two-component systems in Porphyromonas gingivalis.
His goal is to characterize the molecular mechanisms essential for virulent bacteria including Salmonella, Escherichia coli and Yersinia. Shi also investigates post-transcriptional regulation of metal ion homeostasis of enteric pathogenic bacteria in the conditions that mimic host environments. His work also addresses regulatory mechanisms underlying secretion of the proteinases of P. gingivalis (e.g., gingipains) and possibly other virulence factors as well through novel secretion system.
Shi received his Ph.D. in bacterial genetics from Kyushu University, Japan, and served as a postdoctoral research associate in the Department of Molecular Microbiology at Washington University School of Medicine, St. Louis.