Publications

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  1. Kang, Y.; Zhou, X. E.; Gao, X.; He, Y.; Liu, W.; Ishchenko, A.; Barty, A.; White, T. A.; Yefanov, O.; Han, G. W.; Xu, Q.; de Waal, P. W.; Ke, J.; Tan, M. H. E.; Zhang, C.; Moeller, A.; West, G. M.; Pascal, B. D.; Van Eps, N.; Caro, L. N.; Vishnivetskiy, S. A.; Lee, R. J.; Suino-Powell, K. M.; Gu, X.; Pal, K.; Ma, J.; Zhi, X.; Boutet, S.; Williams, G. J.; Messerschmidt, M.; Gati, C.; Zatsepin, N. A.; Wang, D.; James, D.; Basu, S.; Roy-Chowdhury, S.; Conrad, C. E.; Coe, J.; Liu, H.; Lisova, S.; Kupitz, C.; Grotjohann, I.; Fromme, R.; Jiang, Y.; Tan, M.; Yang, H.; Li, J.; Wang, M.; Zheng, Z.; Li, D.; Howe, N.; Zhao, Y.; Standfuss, J.; Diederichs, K.; Dong, Y.; Potter, C. S.; Carragher, B.; Caffrey, M.; Jiang, H.; Chapman, H. N.; Spence, J. C. H.; Fromme, P.; Weierstall, U.; Ernst, O. P.; Katritch, V.; Gurevich, V. V.; Griffin, P. R.; Hubbell, W. L.; Stevens, R. C.; Cherezov, V.; Melcher, K.; Xu, H. E., Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature 2015, advance online publication.

  2. Zhang, H.; Unal, H.; Gati, C.; Han, Gye W.; Liu, W.; Zatsepin, Nadia A.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Sawaya, Michael R.; Xu, Q.; Messerschmidt, M.; Williams, Garth J.; Boutet, S.; Yefanov, Oleksandr M.; White, Thomas A.; Wang, C.; Ishchenko, A.; Tirupula, Kalyan C.; Desnoyer, R.; Coe, J.; Conrad, Chelsie E.; Fromme, P.; Stevens, Raymond C.; Katritch, V.; Karnik, Sadashiva S.; Cherezov, V., Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography. Cell 2015,  (0).

  3. Fenalti, G.; Zatsepin, N. A.; Betti, C.; Giguere, P.; Han, G. W.; Ishchenko, A.; Liu, W.; Guillemyn, K.; Zhang, H.; James, D.; Wang, D.; Weierstall, U.; Spence, J. C. H.; Boutet, S.; Messerschmidt, M.; Williams, G. J.; Gati, C.; Yefanov, O. M.; White, T. A.; Oberthuer, D.; Metz, M.; Yoon, C. H.; Barty, A.; Chapman, H. N.; Basu, S.; Coe, J.; Conrad, C. E.; Fromme, R.; Fromme, P.; Tourwé, D.; Schiller, P. W.; Roth, B. L.; Ballet, S.; Katritch, V.; Stevens, R. C.; Cherezov, V., Structural basis for bifunctional peptide recognition at human δ-opioid receptor. Nat Struct Mol Biol 2015, 22 (3), 265-268.


2014

  1. Gater, D. L.; Saurel, O.; Iordanov, I.; Liu, W.; Cherezov, V.; Milon, A., Two Classes of Cholesterol Binding Sites for the β 2 AR Revealed by Thermostability and NMR. Biophysical journal 2014, 107 (10), 2305-2312.

  2. Yin, X.; Xu, H.; Hanson, M.; Liu, W., GPCR crystallization using lipidic cubic phase technique. Current pharmaceutical biotechnology 2014, 15 (10), 971-979.

  3. Liu, W.; Ishchenko, A.; Cherezov, V., Preparation of microcrystals in lipidic cubic phase for serial femtosecond crystallography. Nat. Protocols 2014, 9 (9), 2123-2134.

  4. Liu, W.; Wacker, D.; Wang, C.; Abola, E.; Cherezov, V., Femtosecond crystallography of membrane proteins in the lipidic cubic phase. Philosophical Transactions of the Royal Society of London B: Biological Sciences 2014, 369 (1647).

  5. Weierstall, U.; James, D.; Wang, C.; White, T. A.; Wang, D.; Liu, W.; Spence, J. C. H.; Bruce Doak, R.; Nelson, G.; Fromme, P.; Fromme, R.; Grotjohann, I.; Kupitz, C.; Zatsepin, N. A.; Liu, H.; Basu, S.; Wacker, D.; Won Han, G.; Katritch, V.; Boutet, S.; Messerschmidt, M.; Williams, G. J.; Koglin, J. E.; Marvin Seibert, M.; Klinker, M.; Gati, C.; Shoeman, R. L.; Barty, A.; Chapman, H. N.; Kirian, R. A.; Beyerlein, K. R.; Stevens, R. C.; Li, D.; Shah, S. T. A.; Howe, N.; Caffrey, M.; Cherezov, V., Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography. Nat Commun 2014, 5.


2013

  1. Wang, C.; Wu, H.; Katritch, V.; Han, G. W.; Huang, X.-P.; Liu, W.; Siu, F. Y.; Roth, B. L.; Cherezov, V.; Stevens, R. C., Structure of the human smoothened receptor bound to an antitumour agent. Nature 2013, 497 (7449), 338-343.

  2. Wang, C.; Jiang, Y.; Ma, J.; Wu, H.; Wacker, D.; Katritch, V.; Han, G. W.; Liu, W.; Huang, X.-P.; Vardy, E.; McCorvy, J. D.; Gao, X.; Zhou, X. E.; Melcher, K.; Zhang, C.; Bai, F.; Yang, H.; Yang, L.; Jiang, H.; Roth, B. L.; Cherezov, V.; Stevens, R. C.; Xu, H. E., Structural Basis for Molecular Recognition at Serotonin Receptors. Science 2013, 340 (6132), 610-614.

  3. Wacker, D.; Wang, C.; Katritch, V.; Han, G. W.; Huang, X.-P.; Vardy, E.; McCorvy, J. D.; Jiang, Y.; Chu, M.; Siu, F. Y.; Liu, W.; Xu, H. E.; Cherezov, V.; Roth, B. L.; Stevens, R. C., Structural Features for Functional Selectivity at Serotonin Receptors. Science 2013, 340 (6132), 615-619.

  4. Siu, F. Y.; He, M.; de Graaf, C.; Han, G. W.; Yang, D.; Zhang, Z.; Zhou, C.; Xu, Q.; Wacker, D.; Joseph, J. S.; Liu, W.; Lau, J.; Cherezov, V.; Katritch, V.; Wang, M.-W.; Stevens, R. C., Structure of the human glucagon class B G-protein-coupled receptor. Nature 2013, 499 (7459), 444-449.

  5. Liu, W.; Wacker, D.; Gati, C.; Han, G. W.; James, D.; Wang, D.; Nelson, G.; Weierstall, U.; Katritch, V.; Barty, A.; Zatsepin, N. A.; Li, D.; Messerschmidt, M.; Boutet, S.; Williams, G. J.; Koglin, J. E.; Seibert, M. M.; Wang, C.; Shah, S. T. A.; Basu, S.; Fromme, R.; Kupitz, C.; Rendek, K. N.; Grotjohann, I.; Fromme, P.; Kirian, R. A.; Beyerlein, K. R.; White, T. A.; Chapman, H. N.; Caffrey, M.; Spence, J. C. H.; Stevens, R. C.; Cherezov, V., Serial Femtosecond Crystallography of G Protein–Coupled Receptors. Science 2013, 342 (6165), 1521-1524.

  6. Lane, J. R.; Chubukov, P.; Liu, W.; Canals, M.; Cherezov, V.; Abagyan, R.; Stevens, R. C.; Katritch, V., Structure-Based Ligand Discovery Targeting Orthosteric and Allosteric Pockets of Dopamine Receptors. Molecular Pharmacology 2013, 84 (6), 794-807.

  7. Gutiérrez-de-Terán, H.; Massink, A.; Rodríguez, D.; Liu, W.; Han, Gye W.; Joseph, Jeremiah S.; Katritch, I.; Heitman, Laura H.; Xia, L.; Ijzerman, Adriaan P.; Cherezov, V.; Katritch, V.; Stevens, Raymond C., The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor. Structure 2013, 21 (12), 2175-2185.


2012

  1. Wu, H.; Wacker, D.; Mileni, M.; Katritch, V.; Han, G. W.; Vardy, E.; Liu, W.; Thompson, A. A.; Huang, X.-P.; Carroll, F. I.; Mascarella, S. W.; Westkaemper, R. B.; Mosier, P. D.; Roth, B. L.; Cherezov, V.; Stevens, R. C., Structure of the human [kgr]-opioid receptor in complex with JDTic. Nature 2012, 485 (7398), 327-332.

  2. Thompson, A. A.; Liu, W.; Chun, E.; Katritch, V.; Wu, H.; Vardy, E.; Huang, X.-P.; Trapella, C.; Guerrini, R.; Calo, G.; Roth, B. L.; Cherezov, V.; Stevens, R. C., Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature 2012, 485 (7398), 395-399.

  3. Santos, J. S.; Asmar-Rovira, G. A.; Han, G. W.; Liu, W.; Syeda, R.; Cherezov, V.; Baker, K. A.; Stevens, R. C.; Montal, M., Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes. Journal of Biological Chemistry 2012, 287 (51), 43063-43070.

  4. Liu, W.; Chun, E.; Thompson, A. A.; Chubukov, P.; Xu, F.; Katritch, V.; Han, G. W.; Roth, C. B.; Heitman, L. H.; IJzerman, A. P.; Cherezov, V.; Stevens, R. C., Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions. Science 2012, 337 (6091), 232-236.

  5. Fairman, James W.; Dautin, N.; Wojtowicz, D.; Liu, W.; Noinaj, N.; Barnard, Travis J.; Udho, E.; Przytycka, Teresa M.; Cherezov, V.; Buchanan, Susan K., Crystal Structures of the Outer Membrane Domain of Intimin and Invasin from Enterohemorrhagic E. coli and Enteropathogenic Y. pseudotuberculosis. Structure 2012, 20 (7), 1233-1243.

  6. Chun, E.; Thompson, Aaron A.; Liu, W.; Roth, Christopher B.; Griffith, Mark T.; Katritch, V.; Kunken, J.; Xu, F.; Cherezov, V.; Hanson, Michael A.; Stevens, Raymond C., Fusion Partner Toolchest for the Stabilization and Crystallization of G Protein-Coupled Receptors. Structure 2012, 20 (6), 967-976.


2011

  1. Xu, F.; Liu, W.; Hanson, M. A.; Stevens, R. C.; Cherezov, V., Development of an Automated High Throughput LCP-FRAP Assay to Guide Membrane Protein Crystallization in Lipid Mesophases. Crystal Growth & Design 2011, 11 (4), 1193-1201.

  2. Tiefenbrunn, T.; Liu, W.; Chen, Y.; Katritch, V.; Stout, C. D.; Fee, J. A.; Cherezov, V., High Resolution Structure of the ba3 Cytochrome c Oxidase from Thermus thermophilus in a Lipidic Environment. PLoS ONE 2011, 6 (7), e22348.

  3. Shimamura, T.; Shiroishi, M.; Weyand, S.; Tsujimoto, H.; Winter, G.; Katritch, V.; Abagyan, R.; Cherezov, V.; Liu, W.; Han, G. W.; Kobayashi, T.; Stevens, R. C.; Iwata, S., Structure of the human histamine H1 receptor complex with doxepin. Nature 2011, 475 (7354), 65-70.

  4. Liu, W.; Cherezov, V., Crystallization of Membrane Proteins in Lipidic Mesophases. 2011,  (49), e2501.

  5. Joseph, J. S.; Liu, W.; Kunken, J.; Weiss, T. M.; Tsuruta, H.; Cherezov, V., Characterization of lipid matrices for membrane protein crystallization by high-throughput small angle X-ray scattering. Methods 2011, 55 (4), 342-349.

  6. Wu, B.; Chien, E. Y. T.; Mol, C. D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F. C.; Hamel, D. J.; Kuhn, P.; Handel, T. M.; Cherezov, V.; Stevens, R. C., Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science 2010, 330 (6007), 1066-1071.

 


2010

  1. Liu, W.; Hanson, M. A.; Stevens, R. C.; Cherezov, V., LCP-Tm: An Assay to Measure and Understand Stability of Membrane Proteins in a Membrane Environment. Biophysical Journal 2010, 98 (8), 1539-1548.

  2. Chien, E. Y. T.; Liu, W.; Zhao, Q.; Katritch, V.; Won Han, G.; Hanson, M. A.; Shi, L.; Newman, A. H.; Javitch, J. A.; Cherezov, V.; Stevens, R. C., Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist. Science 2010, 330 (6007), 1091-1095.

  3. Cherezov, V.; Liu, W.; Derrick, J. P.; Luan, B.; Aksimentiev, A.; Katritch, V.; Caffrey, M., In meso crystal structure and docking simulations suggest an alternative proteoglycan binding site in the OpcA outer membrane adhesin. Proteins: Structure, Function, and Bioinformatics 2008, 71 (1), 24-34.

  4. Liu, W.; Caffrey, M., Interactions of Tryptophan, Tryptophan Peptides, and Tryptophan Alkyl Esters at Curved Membrane Interfaces†. Biochemistry 2006, 45 (39), 11713-11726.

  5. Cherezov, V.; Yamashita, E.; Liu, W.; Zhalnina, M.; Cramer, W. A.; Caffrey, M., In Meso Structure of the Cobalamin Transporter, BtuB, at 1.95 Å Resolution. Journal of Molecular Biology 2006, 364 (4), 716-734.

  6. Liu, W.; Caffrey, M., Gramicidin structure and disposition in highly curved membranes. Journal of Structural Biology 2005, 150 (1), 23-40.