News/Events

ASU appoints world-renowned evolutionary biologist to lead new Biodesign Center

September 6, 2017

Cross-disciplinary center studies key forces behind evolution to empower life sciences The Biodesign Institute at Arizona State University has announced today the appointment of world-renowned evolutionary biologist Michael Lynch, Ph.D., as the director of an ambitious new effort to advance the u­nderstanding of evolution across all scales of life, from whole populations to the key forces at work deep within a cell. The overarching mission of Lynch’s new Biodesign Center for Mechanisms...

Dissecting the Polymodal Gating and Modulation of TRP Channels

August 2, 2017

Wade Van Horn, Ph.D., Assistant Professor, Biodesign Virginia G. Piper Center for Personalized Diagnostics, presents:  Transient receptor potential ion channels serve as polymodal-regulated sensors, which are widely expressed in diverse tissues of higher organisms. A subset of the TRP channel family senses biological temperature, where changes in thermal energy are converted to conformational change (work), a feature central to thermosensing and thermoregulation. In addition to...

New research sheds light on ‘gender gap’ in cystic fibrosis

September 9, 2016

A minor hiccup in the sequence of a human gene can have devastating impacts on health. Such flaws cause cystic fibrosis (CF), a disease affecting the lungs and other vital organs, often leading to death by the age of 30. In new research appearing in the current issue of Science Advances, Wade Van Horn and his colleagues from Vanderbilt and Northwestern Universities examine the underpinnings of this deadly affliction, including its apparent disproportionate effect on women, which is due in...

New award accelerates Biodesign’s efforts in synthetic biology

October 8, 2014

A new four-year, multi-million dollar award from the Defense Advanced Research Projects Agency or DARPA will be used to develop the technology necessary to synthesize, screen, and sequence artificial genetic polymers composed of threose nucleic acid (TNA). John Chaput, a professor in the Department of Chemistry and Biochemistry and research investigator in the Biodesign Institute will lead ASU’s effort to evolve TNA molecules that fold into novel 3D shapes with ligand binding affinity and...