Publications

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2016

  1. Dugger BN, Whiteside CM, Maarouf CL, Walker DG, Beach TG, Sue LI, Garcia A, Dunckley T, Meechoovet B, Reiman EM, Roher AE. The Presence of Select Tau Species in Human Peripheral Tissues and Their Relation to Alzheimer's Disease. J Alzheimers Dis. 2016 Feb 3;51(2):345-56. doi: 10.3233/JAD-150859.
  2. Henderson-Smith A, Corneveaux JJ, De Both M, Cuyugan L, Liang WS, Huentelman M, Adler C, Driver-Dunckley E, Beach TG, Dunckley TL. Next-Generation Profiling to Identify the Molecular Etiology of Parkinson's Dementia. Neurology Genetics, Submitted.

2015

  1. Mennenga SE, Gerson JE, Dunckley T, Bimonte-Nelson HA. Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing. Physiol Behav. 2015 Jan;138:260-5.

2013

  1. Medda F, Smith B, Gokhale, V, Shaw A, Dunckley T, Hulme, C. Beyond Secretases: Kinase Inhibitors for the treatment of Alzheimer’s Disease. Ann. Rep. Med. Chem., 2013, 48, 57-71.

  2. Henderson-Smith A, Chow D, Meechoovet B, Aziz M, Jacobson SA, Shill HA, Sabbagh MN, Caviness JN, Adler CH, Driver-Dunckley ED, Beach TG, Yin H, Dunckley T. SMG1 Identified as a Regulator of Parkinson's Disease-Associated alpha-Synuclein through siRNA Screening. PLoS One. 2013 Oct 30;8(10).


2012

  1. Smith B, Medda F, Gokhale V, Dunckley T, Hulme C. Recent Advances in the Design, Synthesis, and Biological Evaluation of Selective DYRK1A Inhibitors: A New Avenue for
    Date Modified: 2/1/16 a Disease Modifying Treatment of Alzheimer's? ACS Chem Neurosci. 2012 Nov 21;3(11):857-72.

  2. Majounie E, Renton AE, Mok K, Dopper EG, Waite A, Rollinson S, Chiò A, Restagno G, Nicolaou N, Simon-Sanchez J, van Swieten JC, Abramzon Y, Johnson JO, Sendtner M, Pamphlett R, Orrell RW, Mead S, Sidle KC, Houlden H, Rohrer JD, Morrison KE, Pall H, Talbot K, Ansorge O; Chromosome 9-ALS/FTD Consortium; French research network on FTLD/FTLD/ALS; ITALSGEN Consortium, Hernandez DG, Arepalli S, Sabatelli M, Mora G, Corbo M, Giannini F, Calvo A, Englund E, Borghero G, Floris GL, Remes AM, Laaksovirta H, McCluskey L, Trojanowski JQ, Van Deerlin VM, Schellenberg GD, Nalls MA, Drory VE, Lu CS, Yeh TH, Ishiura H, Takahashi Y, Tsuji S, Le Ber I, Brice A, Drepper C, Williams N, Kirby J, Shaw P, Hardy J, Tienari PJ, Heutink P, Morris HR, Pickering-Brown S, Traynor BJ. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol. 2012 Apr;11(4):323-30.


2011

  1. Frost D, Meechoovet B, Wang T, Gately S, Giorgetti M, Shcherbakova I, Dunckley T. β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites. PLoS One. 2011 May 6;6(5):e19264.

  2. Robeson RH, Dunckley T. High-content RNA interference assay: analysis of tau hyperphosphorylation as a generic paradigm. Methods Mol Biol. 2011; 700:221-38.

  3. Liang WS, Chen K, Lee W, Sidhar K, Corneveaux JJ, Allen AN, Myers A, Villa S, Meechoovet B, Pruzin J, Bandy D, Fleisher AS, Langbaum JB, Huentelman MJ, Jensen K, Dunckley T, Caselli RJ, Kaib S, Reiman EM. Association between GAB2 haplotype and higher glucose metabolism in Alzheimer's disease-affected brain regions in cognitively normal APOEε4 carriers. Neuroimage. 2011; 54:1896-902.


2010

  1. Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ. Association of CR1, CLU, and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet. 2010; 19(16):3295-301.

  2. Lai SL, Abramzon Y, Schymick JC, Stephan DA, Dunckley T, Dillman A, Cookson M, Calvo A, Battistini S, Giannini F, Caponnetto C, Mancardi GL, Spataro R, Monsurro MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Lombardo F; the ITALSGEN Consortium, Mora G, Restagno G, Chiò A, Traynor BJ. FUS mutations in sporadic amyotrophic lateral sclerosis. Neurobiol Aging. 2010 Feb 4. [Epub ahead of print].

  3. Azorsa DO, Robeson RH, Frost D, Meechoovet B, Brautigam GR, Dickey C, Beaudry C, Basu GD, Holz DR, Hernandez JA, Bisanz KM, Gwinn L, Grover A, Rogers J, Reiman EM, Hutton M, Stephan DA, Mousses D, Dunckley T. High-content siRNA Date Modified: 2/1/16 screening of the kinome identifies kinases involved in Alzheimer’s disease-related tau hyperphosphorylation. BMC Genomics. 2010 11:25.

  4. Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, Kölsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ. Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiol Aging. 2010; 31:901-9.

  5. Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. Neurobiol Aging. 2010; 31:549-66.


2009

Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, Ding J, Crews C, Rafferty I, Washecka N, Hernandez D, Ferrucci L, Bandinelli S, Guralnik J, Macciardi F, Torri F, Lupoli S, Chanock SJ, Thomas G, Hunter DJ, Gieger C, Wichmann HE, Calvo A, Mutani R, Battistini S, Giannini F, Caponnetto C, Mancardi GL, La Bella V, Valentino F, Monsurrò MR, Tedeschi G, Marinou K, Sabatelli M, Conte A, Mandrioli J, Sola P, Salvi F, Bartolomei I, Siciliano G, Carlesi C, Orrell RW, Talbot K, Simmons Z, Connor J, Pioro EP, Dunkley T, Stephan DA, Kasperaviciute D, Fisher EM, Jabonka S, Sendtner M, Beck M, Bruijn L, Rothstein J, Schmidt S, Singleton A, Hardy J, Traynor BJ. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum Mol Genet. 2009; 18:1524-1532.


2008

  1. Stamper C, Siegel A, Liang WS, Pearson JV, Stephan DA, Shill H, Connor D, Caviness JN, Sabbagh M, Beach TG, Adler CH, Dunckley T. Neuronal gene expression correlates of Parkinson’s disease with dementia. Mov Disord. 2008; 23:1588-1595.

  2. Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Grover A, Niedzielko TL, Schneider LE, Mastroeni D, Caselli R, Kukull W, Morris JC, Hulette CM, Schmechel D, Rogers J, Stephan DA. Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A. 2008; 105:4441-6.

  3. Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, Ramsey K, Caselli RJ, Kukull WA, McKeel D, Morris JC, Hulette CM, Schmechel D, Reiman EM, Rogers J, Stephan DA. Altered neuronal gene expression in brain regions differentially affected by Alzheimer's Disease: A reference data set. Physiol Genomics. 2008;33(2):240-56.

  4. Robeson RR, Siegel A, Dunckley T. Genomic and Proteomic Biomarker Discovery in Neurological Disease. Biomarker Insights. 2008; 3:73-86.


2007

  1. Dunckley TL, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, Halperin RF, Stamper C, Jensen KR, Letizia D, Hesterlee SE, Pestronk A, Levine T, Bertorini T, Graves MC, Mozaffar T, Jackson CE, Bosch P, McVey A, Dick A, Barohn R, Lomen-Hoerth C, Rosenfeld J, O’Connor DT, Zhang K, Crook R, Ryberg H, Hutton M, Katz J, Simpson EP, Mitsumoto H, Bowser R, Miller RG, Appel SH, Stephan DA. Whole Date Modified: 2/1/16 Genome Analysis of Persons with Sporadic Amyotrophic Lateral Sclerosis. New Eng. J Med. 2007; 357:775-788.

  2. Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Huentelman MJ, Craig DW, Coon KD, Liang WS, Herbert RH, Beach T, Rohrer KC, Zhao AS, Leung D, Bryden L, Marlowe L, Kaleem M, Mastroeni D, Grover A, Heward CB, Ravid R, Rogers J, Hutton ML, Melquist S. Petersen RC, Alexander GE, Caselli RJ, Kukull W, Papassotiropoulos A, Stephan DA. GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron. 2007 Jun 7;54(5):713-20.

  3. Liang WS*, Dunckley T*, Beach TG, Grover A, Mastroeni D, Walker DG, Caselli RJ, Kukull WA, Morris JC, Hulette C, Schmechel D, Alexander GE, Reiman EM, Roger J, Stephan DA. Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics. 2007; Feb 12; 28(3):311-22. 20. Coon KD, Dunckley TL, Stephan DA. A generic research paradigm for identification and validation of early molecular diagnostics and new therapeutics in common disorders. Mol Diagn Ther. 2007;11(1):1-14.


2006

  1. Dunckey T, Liang WS, Stephan DA. Evolution of translational genomic research strategies. In Williams, CR (ed) Trends in Genome Research. 2006 Nova Science Publishers, Inc., Hauppauge, NY pp 1-24.

  2. Dunckley T, Coon K, Stephan D. (2006) Genetic Information and Cancer. In: Ganten, D & Ruckpaul, K (eds). Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. 2006 Springer, Berlin Heidelberg New York, pp 693-696. 17. Dunckley T and Lukas R. Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006; 1116: 39-49.

  3. Coon KD, Siegel AM, Yee SJ, Dunckley TL, Mueller C, Nagra RM, Tourtellotte WW, Reiman EM. Preliminary demonstration of an allelic association of the IREB2 gene with Alzheimer's disease. J Alzheimers Dis. 2006; 9: 225-233.

  4. Quantitation of heteroplasmy of mtDNA sequence variants identified in a population of AD patients and controls by array-based resequencing. Mitochondrion. 2006 Aug;6(4):194-210.

  5. Segal SP, Dunckley T, Parker R. Sbp1p affects translational repression and decapping in Saccharomyces cerevisiae. Mol Cell Biol. 2006; 26: 5120-5130.

  6. Papassotiropoulos A, Fountoulakis M, Dunckley T, Stephan DA, Reiman EM. Genetics, Transcriptomics and Proteomics of Alzheimer's Disease. J. Clin. Psych. 2006; 67: 652-670.

  7. Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, Walker DG, LaFleur BJ, Coon KD, Brown KM, Caselli R, Kukull W, Higdon R, McKeel D, Morris JC, Hulette C, Schmechel D, Reiman EM, Rogers J, Stephan DA. Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging. 2006; 27:1359-71. Date Modified: 2/1/16


2005

Dunckley T, Coon K, Stephan DA. Discovery and development of biomarkers of neurological disease. Drug Discov Today 2005; 10: 326-334.


2004

  1. Puffenberger EG, Hu-Lince D, Parod JM, Craig DW, Dobrin SE, Conway AR, Donarum EA, Strauss KA, Dunckley T, Cardenas JF, Melmed KR, Wright CA, Liang W, Stafford PNMI, Flynn CR, Morton DH, Stephan DA. A high-density SNP genome scan identifies TSPYL loss-of-function as causative of Swarey syndrome. Proc Nat Acad Sci USA 2004; 101: 11689-11694.

  2. Dunckley T, Coon K, Stephan DA. Genomic information and cancer. In Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. (In Press)

  3. Coon K, Dunckley T, Stephan DA. Biomarker Identification in Neurologic Diseases: improving diagnostics and therapeutics. Expert Rev Mol Diagn 2004; 4: 361-375.


2003

Dunckley T, and Lukas R. Nicotine modulates the expression of a diverse set of genes in the human neuronal SH-SY5Y cell line. J Biol Chem 2003; 278: 15633-15640.


2002

Dunckley T, Lingke Z, Wu J, Lukas R. Mutational analysis of roles for extracellular cysteine residues in assembly and function of human 7 nicotinic acetylcholine receptors. Biochemistry 2002; 42: 870-876.


2001

  1. Dunckley T, Parker R. The yeast mRNA decapping enzyme. Methods Enzymol 2001; 342: 226-33.

  2. Dunckley T, Tucker M, Parker R. Two related proteins, Edc1p and Edc2p, stimulate mRNA decapping in Saccharomyces cerevisiae. Genetics 2001; 157: 27-37.


1999

  1. Dunckley T, Parker R. The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J 1999; 18: 5411-5422.

  2. Dunckley T, Parker R. Pathways of mRNA degradation in Eukaryotic Cells. In: Encyclopedia of Genetics. Academic Press, NY, 1999.