Research

Research Interests

Energy production is similar mechanistically to other molecular processes that are studied extensively. Hecht played a key role in the development of Hycamtin, a drug used to treat ovarian and lung cancer, as well as the study of the mechanism of the anti-tumor agent bleomycin. In a career spanning more than three decades, Hecht has held both academic and industrial research positions. He joins ASU from the University of Virginia, where he was a professor of both chemistry and biology. From 1981 to 1987, he concurrently held leadership positions in research and development for Smith Kline and French Laboratories. Prior to his 28 years at the University of Virginia, he was a faculty member at MIT. Hecht is the co-founder of Edison Pharmaceuticals, a pharmaceutical company focusing on inherited mitochondrial disorders. He earned a BA in chemistry from the University of Rochester and a PhD in chemistry with emphasis in biochemistry from the University of Illinois.

Research activity

  1. Petuskey,William T * , Bimonte-Nelson,Heather , Coon,David Wayne , Gonzalez,Graciela H , Hecht,Sidney Michael , Sierks,Michael Richard ,Smith,Brian , Petuskey,William T * , Bimonte-Nelson,Heather , Coon,David Wayne , Gonzalez,Graciela H , Hecht,Sidney Michael ,Sierks,Michael Richard , Smith,Brian , Wang,Yalin , . FY14: Arizona Alzheimer's Disease Consortium. AADC (12/22/2014 - 6/30/2014).
  2. Hecht,Sidney Michael * Dedkova,Larisa . Selection of Modified Ribosomes Using Novel Puromycins. HHS-NIH-NIBIB (9/13/2013 - 8/31/2016).
  3. Chang,Yung * , Hecht,Sidney Michael , Kumar,Sudhir , Yan,Hao , . Rational design and targeted selection of effective DNA-scaffolded nicotine vaccines (Chang). HHS-NIH-NIDA (4/15/2013 - 2/29/2016).
  4. Hecht,Sidney Michael * . Mulltifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders Evaluation in Cellular Disease Models. UMDF (9/17/2012 - 10/31/2013).
  5. Hecht,Sidney Michael * . Multifunctional Radical Quenchers for the Treatment of Mitochondrial Disorders Exploration of the MRQ B Series.UMDF (9/17/2012 - 12/31/2013).
  6. Hecht,Sidney Michael * . Advanced Generation Multifunctional Radical Quenchers. FARA (8/1/2012 - 10/30/2013).
  7. Hecht,Sidney Michael * . Misacylated Suppressor tRNA Transcripts. SAIC (10/1/2011 - 1/16/2014).
  8. Chang,Yung * Hecht,Sidney Michael Yan,Hao . TURNABLE NICOTINE DNA-NANOVACCINES. HHS-NIH-NIDA (4/1/2011 - 3/31/2014).
  9. Hecht,Sidney Michael * . Therapeutic Strategies for rescuing mitochondrial function in Alzhemier's disease. Banner (1/1/2011 - 6/30/2012).
  10. Hecht,Sidney Michael * . Multifunctional Radical Quenchers for the Treatment of Friedreich's Ataxia. FARA (6/5/2010 - 12/31/2011).
  11. Hecht,Sidney Michael * . Dynamic Properties that Enhance Enzyme Function. HHS-NIH-NIGMS (4/1/2010 - 3/31/2015).
  12. Hecht,Sidney Michael * . Molecular Recognition by Bleomycin. HHS-NIH-NCI (1/18/2010 - 12/31/2015).
  13. Hecht,Sidney Michael * . Bleomycin-induced Pulmonary Toxicity: Origins and Mechanisms of Pro-fibrotic Activities in the Lung. MAYO CLINIC SCOTTSDALE (1/1/2009 - 12/31/2009).
  14. Hecht,Sidney Michael * . Inhibitors of p90Rsk. HHS-NIH-NCI (8/6/2008 - 1/31/2010).
  15. Hecht,Sidney Michael * . Analysis and Restoration of Mitochondrial Function. FARA (5/15/2008 - 8/31/2009).

* principal investigator