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  1. Xun Ji, Qi Chen, Viswanath Arutla, Omar Khdour, Qiong-Ying Hu, Shengxi Chen. Double-component diazeniumdiolate derivatives as anti-cancer agents. Bioorganic & Medicinal Chemistry 28, 115405 (2020).

  2. Zhang C, Chen S, Bai X, Dedkova LM, Hecht SM. Alteration of Transcriptional Regulator Rob In Vivo: Enhancement of Promoter DNA Binding and Antibiotic Resistance in the Presence of Nucleobase Amino Acids. Biochemistry. 59, 1217-1220 (2020). doi: 10.1021/acs.biochem.0c00103.

  3. Chao Zhang, Mengnan Han, Fanghua Zhang, Xueli Yang, Jie Du, Honglei Zhang, Wei Li, Shengxi Chen. Enhancing antitumor efficacy of nucleoside analog 5-fluorodeoxyuridine on HER2-overexpressing breast cancer by affibody-engineered DNA nanoparticle. International Journal of Nanomedicine 15, 885–900 (2020).​


  1. Mingxuan Gao, Jesse J. Waggoner, Sidney M. Hecht, Shengxi Chen. Selective detection of dengue virus serotypes using tandem toehold-mediated displacement reactions. ACS Infectious Diseases 5, 1907-1914 (2019).

  2. Shengxi Chen, Xun Ji, Mingxuan Gao, Larisa M. Dedkova, and Sidney M. Hecht. In cellulo synthesis of proteins containing a fluorescent oxazole amino acid. Journal of the American Chemical Society 141, 5597–5601 (2019).

  3. Chao Zhang, Honglei Zhang, Mengnan Han, Xueli Yang, Chaohong Pei, Zhidong Xu, Jie Du, Wei Li and Shengxi Chen. DNA–affibody nanoparticle delivery system for cisplatin-based breast cancer chemotherapy. RSC Advances 9, 1982-1989 (2019).​


  1. Mingxuan Gao, Douglas Daniel, Hongyan Zou, Shouxing Jiang, Su Lin, Chengzhi Huang, Sidney M. Hecht, and Shengxi Chen. Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions. Chem. Commun. 54, 968-971 (2018).


  1. Rapid detection of a dengue virus RNA sequence with single molecule sensitivity using tandem toehold-mediated displacement reactions. Gao M, Daniel D, Zou H, Jiang S, Lin S, Huang C, Hecht SM, Chen S. Chem Commun (Camb). 2018 Jan 23;54(8):968-971. doi: 10.1039/c7cc09131a. PMID: 29319084

  2. Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB. Chen S, Maini R, Bai X, Nangreave RC, Dedkova LM, Hecht SM. J Am Chem Soc. 2017 Oct 11;139(40):14098-14108. doi: 10.1021/jacs.7b05168. Epub 2017 Sep 27. PMID: 28898075

  3. Bai X, Talukder P, Daskalova SM, Roy B, Chen S, Li Z, Dedkova LM, Hecht SM. Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids. J Am Chem Soc. 2017 Apr 5;139(13):4611-4614. doi: 10.1021/jacs.6b11825. Epub 2017 Mar 17. PubMed PMID: 28263595.

  4. Zhang Y, Jiang S, Zhang D, Bai X, Hecht SM, Chen S. DNA-affibody nanoparticles for inhibiting breast cancer cells overexpressing HER2. Chem Commun (Camb). 2017 Jan 3;53(3):573-576. doi: 10.1039/c6cc08495h. PubMed PMID: 27975087.


  1. Chowdhury SR, Chauhan PS, Dedkova LM, Bai X, Chen S, Talukder P, Hecht SM. Synthesis and Evaluation of a Library of Fluorescent Dipeptidomimetic Analogues as Substrates for Modified Bacterial Ribosomes. Biochemistry. 2016 May 3;55(17):2427-40. doi: 10.1021/acs.biochem.6b00102. Epub 2016 Apr 21.


  1. Talukder P, Chen S, Roy B, Yakovchuk P, Spiering MM, Alam MP, Madathil MM, Bhattacharya C, Benkovic SJ, Hecht SM. Cyanotryptophans as Novel Fluorescent Probes for Studying Protein Conformational Changes and DNA-Protein Interaction.Biochemistry. 2015 Dec 29;54(51):7457-69. doi: 10.1021/acs.biochem.5b01085. Epub 2015 Dec 16.

  2. Maini R, Dedkova LM, Paul R, Madathil MM, Chowdhury SR, Chen S, Hecht SM. Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro. J Am Chem Soc. 2015 Sep 9;137(35):11206-9. doi: 10.1021/jacs.5b03135. Epub 2015 Aug 31.

  3. Maini R, Chowdhury SR, Dedkova LM, Roy B, Daskalova SM, Paul R, Chen S, Hecht SM. Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids. Biochemistry. 2015 Jun 16;54(23):3694-706. doi: 10.1021/acs.biochem.5b00389. Epub 2015 Jun 2.

  4. Wang Z, Talukder P, Hecht SM, Chen SFluorescent CD4 probe for potential HIV-1 gp120 protein detection. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1182-5. doi: 10.1016/j.bmcl.2015.01.071. Epub 2015 Feb 7.

  5. Wu D, Jiang H, Chen S, Zhang H.Inhibition of microRNA-101 attenuates hypoxia/reoxygenation‑induced apoptosis through induction of autophagy in H9c2 cardiomyocytes. Mol Med Rep. 2015 May;11(5):3988-94. doi: 10.3892/mmr.2015.3215. Epub 2015 Jan 16.


  1. Zhiqiang Yu, Bin Yu, Justin Boy Kaye, Chenhong Tang, Shengxi Chen, Chenbo Dong, and Bing Shen. Perspectives and Challenges of Cell-Penetrating Peptides in Effective siRNA Delivery. Nano LIFE, 4, 1441016 (2014)

  2. Xiaobo Yu, Poulami Talukder, Chandrabali Bhattacharya, Nour Eddine Fahmi, Jamie A. Lines, Larisa M. Dedkova, Joshua LaBaer, Sidney M. Hecht, Shengxi Chen*. Probing of CD4 binding pocket of HIV-1 gp120 glycoprotein using unnatural phenylalanine analogues. Bioorg. Med. Chem. Lett. 24, 5699-5703 (2014).

  3. Jamie A. Lines, Zhiqiang Yu, Larisa M. Dedkova and Shengxi Chen*. Design and expression of a short peptide as an HIV detection probe. Biochemical and Biophysical Research Communications, 443, 308-312 (2014).

  4. Poulami Talukder, Shengxi Chen, C. Tony Liu, Edwin A. Baldwin, Stephen J. Benkovic, and Sidney M. Hecht. Tryptophan Derivatives as Probes of Protein Conformational Changes. Bioorganic & Medicinal Chemistry, 22, 5924-5934, (2014).

  5. Poulami Talukder, Shengxi Chen, Pablo M. Arce and Sidney M. Hecht. Efficient asymmetric synthesis of trypophan analogues having useful photophysical properties. Organic Letters, 16, 556-559 (2014).


  1. Shengxi Chen, Nour Eddine Fahmi, Chandrabali Bhattacharya, Lin Wang, Yuguang Jin, Stephen J. Benkovic and Sidney M. Hecht. Fluorescent biphenyl derivatives of phenylalanine suitable for protein modification. Biochemistry, 52, 8580-8589 (2013).

  2. Shengxi Chen, Nour Eddine Fahmi, Lin Wang, Chandrabali Bhattacharya, Stephen J. Benkovic and Sidney M. Hecht. Detection of DHFR conformational change by FRET using two fluorescent amino acids. Journal of the American Chemical Society, 135, 12924-12927 (2013).

  3. Rumit Maini, Dan T. Nguyen, Shengxi Chen, Larisa M. Dedkova, Sandipan Roy Chowdhury, Rafael Alcala-Torano, Sidney M. Hecht. Incorporation of b-amino acids into dihydrofolate reductase by ribosomes having modifications in the peptidyltransferase center. Bioorganic & Medicinal Chemistry, 21, 1088-1096 (2013).


  1. Shengxi Chen, Lin Wang, Nour Eddine Fahmi, Stephen J. Benkovic and Sidney M. Hecht. Two pyrenylalanines in dihydrofolate reductase form an excimer enabling the study of protein dynamics. Journal of the American Chemical Society. 134, 18883-18885 (2012).

  2. Shengxi Chen, Nour Eddine Fahmi, Ryan C. Nangreave, Youcef Mehellou and Sidney M. Hecht. Synthesis of pdCpAs and transfer RNAs activated with thiothreonine and derivatives. Organic & Biomolecular Chemistry, 20, 2679-2689 (2012).

  3. Larisa M. Dedkova, Nour Eddine Fahmi, Rakesh Paul, Melissa del Rosario, Liqiang Zhang, Shengxi Chen, Glen Feder and Sidney M. Hecht. b-Puromycin selection of modified ribosomes for in vitro incorporation of b-amino acids, Biochemistry, 51, 401-415 (2012).


  1. Shengxi Chen, Yi Zhang and Sidney M. Hecht. p-Thiophenylalanine-induced DNA cleavage and religation activity of a modified vaccinia topoisomerase IB, Biochemistry, 50, 9340-9351 (2011).

  2. Ryan C. Nangreave, Larisa M. Dedkova, Shengxi Chen and Sidney M. Hecht. A new strategy for the synthesis of bisaminoacylated tRNAs, Organic Letters, 13, 4906–4909 (2011).


  1. Shengxi Chen and Sidney M. Hecht. Synthesis of pdCpAs and transfer RNAs activated with derivatives of aspartic acid and cysteine, Bioorganic & Medicinal Chemistry, 16, 9023-9031 (2008).

  2. Maria Duca, Shengxi Chen and Sidney M. Hecht. Modeling the reactive properties of tandemly activated tRNAs. Organic & Biomolecular Chemistry, 6, 3292-3299 (2008).

  3. Maria Duca, Shengxi Chen and Sidney M. Hecht. Aminoacylation of transfer RNAs with one and two amino acids. Methods, 44, 87-99 (2008).

  4. Lyudmila Yakovleva, Shengxi Chen, Sidney M. Hecht, and Stewart Shuman. Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provide insights to cleavage site recognition and transesterification chemistry. Journal of Biological Chemistry, 283, 16093-16103 (2008).


  1. David J. Maloney, Shengxi Chen and Sidney M. Hecht. Stereoselective synthesis of the atropisomers of myristinin B/C. Organic Letters, 8, 1925-1927 (2006).


  1. Shengxi Chen and Huiyuan Guo. Synthesis and antibacterial activity of 7-[(2S)-2-hydroxymethyl-4- amino-pyrrolindine-1-yl]-quinolone derivatives. Chinese Journal of Pharmaceuticals, 36, 129-132 (2005).


  1. Shengxi Chen and Huiyuan Guo. Synthesis and antibacterial activity of 7-[(2S)-2-aminomethyl -pyrrolindine-1-yl]-quinolone derivatives. Chinese Journal of Antibiotics, 29, 397-400 (2004).


  1. Shengxi Chen and Xiandong Xu. Synthesis of 9-oxime-6-O-methyl-3-oxo erythromycin. Chinese Journal of Pharmaceuticals, 34, 58-59 (2003).


  1. Shengxi Chen and Jie Dai. Research development of preventive and curative drugs against AIDS. World Notes on Antibiotics, 23, 155-157 (2002).

  2. Shengxi Chen and Huiyuan Guo. Novel fluoroquinoloe-gemifloxacin. World Notes on Antibiotics, 23, 279-283 (2002).


  1. Shengxi Chen, Xiandong Xu and Lanxiang Yu. Synthesis and antibacterial activity of 3-hydroxy-6-O- methylerythromycin-9-O-substituted oxime derivatives. Acta Pharmaceutica Sinica, 36, 581-584 (2001).

  2. Shengxi Chen and Huiyuan Guo. Pharmacokinetics and pharmacodynamics of fluoroquinoloe. World Notes on Antibiotics, 22, 253-258 (2001).

  3. Shengxi Chen, Xiandong Xu and Lanxiang Yu. 3-Keto-9-O-substituted oxime derivatives of 6-O-methyl erythromycin A, synthesis and in vitro activity. J. Antibiotics, 54, 506-509 (2001).