Our main research interest lies in the interdisciplinary area of nanoscience and biology/biophysics. We focus on:

  • Rational synthesis and assembly of 0-D and 1-D metal/semiconductor materials into complex and ordered structures

  • Studies of the basic chemical and physical properties of such materials/structures with the emphasis on pushing to the limit of ultra-sensitive detection of molecular interactions, especially those involved in biological processes

  • Innovations of bio-probes using these nanoscale building blocks to harmonically bridge artificial electronics with live biological systems

Bottom-up design of functional nanomaterials/nanostructures

The fundamental understanding and capability of engineering materials/structures at atomic/nanoscale is key for revolutionary advances in bioelectronics and biosensors.

Interface with live cells: Bridge the artificial and the biological world

The dimensional and structural advantages of nanoelectronic sensors and the diverse interaction between live cells and nanomaterials/surfaces provide great opportunity for us to rethink how we can bring artificial electronics and live cells together in the most harmonic way.

Single molecule level manipulation and sequencing: Push beyond limits

If we are smart enough to design the size and structure of the sensor to match that of a single molecule, many physical quantities that used to be buried in bulk environment can become detectable. The capability of manipulating and sequencing biopolymers with great biological significance, for example, DNA chains, down to single-molecule level, can bring paradigm shifts in biological research and biomedical practices.