The outbreaks of West Nile Virus (WNV) in North America over the last decade indicate its establishment and continued spread throughout the Western hemisphere. At present, no therapeutic treatment or vaccine is available for human use. The continued expansion of the WNV epidemic demands effective therapeutics and new production technologies that can rapidly transfer them into the clinical setting. During the past few years, Chen's group has generated a promising WNV therapeutic candidates, which can be rapidly scaled-up for commercial production in a cost-effective manner.
In addition, the research knowledge gained can be applied to other flaviruses, including chikungunya and the recent Zika epidemic.
- Chen,Qiang * . Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2014 - 5/31/2017).
- Chen,Qiang * . Bifunctional antibodies with targeted CNS delivery against West Nile virus. HHS-NIH-NIAID (6/1/2012 - 5/31/2014).
- Chen,Qiang * . Alternative Delivery of Human Milk Proteins to Infants. GATES (BILL & MELINDA) FDN (11/1/2011 - 10/31/2013).
- Arntzen,Charles Chen,Qiang Mason,Hugh S Nickerson,Cheryl . SBC: Commercialization of Norovirus Vaccine Technology in an Arizona Spin-off Company. SFAz (7/1/2008 - 12/31/2009).
- Chen,Qiang * Arntzen,Charles . Plant-derived MAb therapeutics for West Nile Virus. HHS-NIH-NIAID (8/1/2007 - 7/31/2012).
- Chen,Qiang . RXOA Subaward: Targeted Homologous Recombination in Meiotic Plant Cells. RXOA (5/15/2007 - 8/31/2008).
- Chen,Qiang * Mason,Hugh S . Protein Production in Tobacco from an Amplified Inducible System Phase I. RXOA (8/1/2006 - 1/31/2007).
- Arntzen,Charles * Chen,Qiang Huang,Zhong Krattiger,Anatole Francois V Mason,Hugh S Slater,Steven Charles . Plant-Derived Vaccines Against Hepatitis C Cooperative Research Center. HHS-NIH-NIAID (8/1/2005 - 7/31/2012).
- Arntzen,Charles * Chen,Qiang Mason,Hugh S . Development of a Vaccine for Ebola Virus in Plant System. HHS-NIH-NIAID (3/15/2005 - 2/28/2011).
- Arntzen,Charles * Chen,Qiang Chen,Qiang Leket-Mor,Tsafrir Shlomo Mason,Hugh S Slater,Steven Charles . Plant-Made Microbicides and Mucosal Vaccines for STIs. HHS-NIH-NIAID (9/1/2004 - 8/31/2011).
* principal investigator