MD, 1983, Beijing Medical University; PhD, 1988, University of Iowa
My main research program has been centered on the study of lymphocyte development. The research projects in this area range from fundamental characterization of the V(D)J recombination process, an essential event in lymphocyte development, to exploration of our inducible leukemia model for identifying new targets for treating leukemia. Recently, by collaborating with photochemists, we have developed a novel fluorescence-based detection system to monitor the recombination cleavage reaction in real-time and provide the first quantitative assessment on coding end retention. This study sheds new light on the molecular mechanism that controls genome integrity during the recombination process.
We have also expanded our research scope and built two new translational research programs related to nanoscience and nanotechnology. In working with DNA-structural chemists, we have been exploring DNA-nanostructures to design and construct various immune modulating agents, which aims to create a new line of therapeutics and vaccines. Moreover, in collaboration with environmental engineers, we have developed several aquatic systems to examine the health and environmental impact of many commonly used nanoparticles.
Liu., X., Y. Xu, T. Yu, C. Clifford, Y. Liu, H. Yan* & Y. Chang*. 2012. A DNA nanostructure platform for directed assembly of synthetic vaccines. Nano Letters (accepted for publication).
Wang, J., X. Zhu, X. Y. Chen* and Y. Chang*. 2012. The application of embryonic and adult zebrafish for assessing nanotoxicology. In Nanotoxicity: Methods and Protocols. Editor: J. J. Reineke. Human Press 2012 (In Press).
Wang, G., K. Dhar, P. C. Swanson, M. Levitus* & Y. Chang*. 2012. Real time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the post-cleavage complex. Nucl. Acid Res. (in press).
Liu, X., H. Yan, Y. Liu* & Y. Chang*. 2011. Targeted Cell-Cell Interactions by DNA Nanoscaffold-Templated Multivalent Bi-specific Aptamers. Small. 7:1673-1682.
Wang, J, X. Zhu, X. Zhang, Z. Zhao, H. Liu, R. George, J. Wilson-Rawls. Y. Chang* and Y. Chen*. 2011. Are TiO2 nanoparticles safe? Disruption of zebrafish (Danio reior) reproduction upon chronic exposure to low concentrations of TiO2 nanoparticles. Chemosphere. 83:461-467.
Zhu, X., Y. Chang* & Y. Chen. 2010. Toxicity and bioaccumulation of TiO2 nanoparticle aggregates in Daphnia magna. Chemosphere. 78:209-215.
Zhu, X, J. Wang, Y*. Zhang, Y. Chang* & Y. Chen*. 2010. Trophic transfer of TiO2 nanoparticles from Daphina to zebrafish in a simplified freshwater food chain. Chemosphere. 79: 928-933.
Franco, D. & Y. Chang. 2009. Accessibility of Chromosomal Recombination Breaks in Nuclei of Wild-type and DNA-PKcs-Deficient cells. DNA Repair. 8: 813-821.
Zhu, X., J. Wang, X. Zhang, Y. Chang* & Y. Chen. 2009. Impact of ZnO nanoparticle aggregates on the embryonic development of Zebrafish (Danio rerio). Nanotechology. 20: 195103 (1-9).
Hahn, K. L., B. Beres, M. Rowton, M. Skinner, Y. Chang, A. Rawls, J. Wilson-Rawls. 2009. A deficiency of Lunatic fringe is associated with defects of the rete testis. Reproduction. 137: 79-93.
Zhao, Z. J. Wang, H. Liu, J. Ye & Y. Chang. 2008. Identifying biologically relevant genes via multiple heterogeneous data sources. KDD 2008: 839-847.
Pavlicek, J, Y. Lyubchenko and Y. Chang. 2008. Revelation of RAG-induced DNA bending by atomic force microscopy. Biochemistry. 47:11204-11.Jentarra, GM, M.C. Heck, J.W. Youn, K. Kibler, J.O. Langland, C. R. Baskin, O. Ananieva, Y. Chang & Jacobs BL. 2008. Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: scarification vaccination. Vaccine. 26:2860-72.
Ke, Y., S. Lindsay, Y. Chang, Y. Liu and H. Yan. 2008. Self-assembled Water-soluble Nanoarrays for Label Free RNA Hybridization Assays. Science 319:180-183.
Wang, Q., Y. Xu, X. Zhao, Y. Chang, Y. Liu, L. Jiang, J. Sharma, D. K. Seo & H. Yan. 2007. A facile one-step in situ functionalization of quantum dots with preserved photoluminescence for bioconjugation. J. Am. Chem. Soc., 129:6380-6381.
Li, Z., Y. Chang. 2007. V(D)J recombination in zebrafish: normal joining products with accumulation of unresolved coding ends and deleted signal ends. Mol. Immunol. 44:1804-1813.
Zhong, H., Z. Li, S. Lin and Y. Chang. 2007. Initiation of V(D)J recombination in zebrafish (Danio rerio) ovaries. Mol. Immunol. 44:1795-1803.
Jacobsen, E. O. Ananieva, M. L. Brown and Y. Chang. 2006. Growth, differentiation and malignant transformation of pre-B cells mediated by inducible activation of v-Abl oncogene. J. Immunol. 176:6831-6838.
Bogani, F. E. McConnell, L. Joshi, Y. Chang, G. Ghirlanda. 2006. A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. J. Am. Chem. Soc. 128:7142-7143.
*: Co-corresponding author