- Postdoctoral Fellow, Johns Hopkins University School of Medicine
- Ph.D., Indiana University-Bloomington
We are interested in understanding the structure, function and evolution of ribonucleoprotein (RNP) complexes in cells. Our attention currently focuses on the telomerase RNP enzyme, a unique reverse transcriptase essential for maintaining telomere length in most eukaryotes. Telomeres act as caps at the ends of chromosomes, and are required for chromosome stability.
Telomerase elongates telomere length by adding telomeric repeats to chromosome ends to counterbalance the natural shortening that occurs during DNA replication. Because of its role in chromosome stability, telomerase regulation is a critical step in tumorigenesis and aging. To maintain chromosome stability and infinite growth, telomerase is activated in immortal cells such as stem cells, germ line as well as 90% of human tumors. Moreover, patients with dyskeratosis congenita, a disease of premature aging, carry a mutation in the telomerase RNA (TR) or the telomerase reverse transcriptase protein (TERT) genes
Elucidation of the molecular mechanism of telomerase function is the main goal of our lab and will have significant medical implications in cancer and aging. Our goals are to understand (1) how telomerase RNP is assembled and regulated in cells, (2) how different components of the complex participate in the regulation of telomerase function, and (3) how this RNP complex evolved in different eukaryotes. Our research employees a variety of approaches involving biochemical and biophysical techniques, as well as molecular genetics and molecular biology.
Julian J.-L. Chen is a Professor of Biochemistry at Arizona State University. His research interests are in structure and function of RNA molecules and ribonucleoprotein complexes. He received his Ph.D degree in molecular biology and biochemistry from Indiana University, Bloomington. He then worked as a postdoctoral fellow in Dr. Carol Greider's laboratory at Johns Hopkins University before he joined the faculty of Arizona State University in 2004. His research at ASU focuses on the structure, function and evolution of telomerase ribonucleoprotein complexes in cells. Telomerase is an enzyme essential for maintaining telomere length at chromosome ends in most eukaryotes. Because of its role in chromosome stability, telomerase regulation is a critical step in tumorigenesis and aging. Elucidation of the molecular mechanism of telomerase function will have significant impact on the development of therapeutics for human cancer and aging.