Diego Mastroeni

Assistant Research Professor
Neurodegenerative Disease Research Center

Location: TEMPE

Contact Information


  1. Bachelor of Science: Extended major Microbiology/Chemistry, Northern Arizona University, Flagstaff, AZ, USA,
  2. Certificate: Medical Technology, Northern Arizona University, Flagstaff, AZ, USA,
  3. Ph.D. - Neuroscience, Emphasis Neuroepigenetics, Maastricht University, Maastricht, Netherlands
  4. Postdoctoral Fellowship- Neuroepigenetics,  Banner Sun Health Research Institute, Sun City, Arizona



Research Interests

  1. Neurodegenerative Diseases 
  2. Healthy Aging
  3. Mitochondrial dysfunction
  4. Single Cells
  5. Microglia
  6. Neuroinflammation
  7. Epigenetics



I?ve been fortunate to have worked with some of the greatest minds in Alzheimer?s research. One of the greatest assets to my success as an independent researcher has been the leadership and continuing support from my mentors.  In addition, the brain bank at Banner Sun Health Research Institute has been instrumental in separating some of my work from the rest of the field.  An example of this can be found in my recent report using laser capture microdissection technology, which allowed us to identify unique pathways in human microglia from Alzheimer's, Parkinson?s and normal control brains. Conventional homogenate studies have been at the forefront of transcriptomics research, but unfortunately the meaning of these data thus far has been obscured since brain homogenates produce data that result from many different classes of cells in many different disease states. Our technology, in combination with RNA sequencing has been instrumental in identifying many unique pathways that would have otherwise been missed in conventional analysis