cmaley1

Carlo Maley

Professor
Biodesign BSS
Associate Faculty
Biodesign ME

Location: TEMPE

Contact Information
maley@asu.edu
(480) 727-7320

Education

  • Ph.D. Massachusetts Institute of Technology 1998
  • M.Sc. University of Oxford 1993
  • B.A. Oberlin College 1991

Research Interests

Professor Maley is a cancer biologist, evolutionary biologist and computational biologist, working at the intersection of those fields. His team applies evolutionary and ecological theory to three problems in cancer: (1) Neoplastic progression: the evolutionary dynamics among cells of a tumor that drive progression from normal tissue to malignant cancers, (2) Acquired therapeutic resistance: the evolutionary dynamics by which our therapies select for resistance and we fail to cure cancer, and (3) the evolution of cancer suppression mechanisms in large, long-lived animals like elephants and whales (a problem called Peto?s Paradox). They use genomic data mining, phylogenetics, computational modeling, as well as wet lab techniques to solve these problems. In all of this work, their goals are to develop better methods to prevent cancer and improve cancer management.

Bio

Carlo Maley is a biologist who specializes in cancer, evolution and computational biology. He works at the intersection of these fields.

Professor Maley and his research team apply evolutionary and ecological theory to three problems in cancer. First, they investigate neoplastic progression: the evolutionary dynamics among cells of a tumor that drive progression from normal tissue to malignant cancers. Second, they examine acquired therapeutic resistance: the evolutionary dynamics by which therapies select for resistance and fail to cure cancer. Third, they look into the evolution of cancer suppression mechanisms in large, long-lived animals such as elephants and whales (a problem called Peto?s Paradox).

His team uses genomic data mining, phylogenetics, computational modeling and wet lab techniques to solve these problems. In their work, the Maley team focus on developing better methods to prevent cancer and improve cancer management.