Publications

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2017

  1. Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction. Roy Chowdhury S, Khdour OM, Bandyopadhyay I, Hecht SM. Bioorg Med Chem. 2017 Oct 15;25(20):5537-5547. doi: 10.1016/j.bmc.2017.08.021. Epub 2017 Aug 18. PMID: 28927904

  2. Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease. Mastroeni D, Khdour OM, Delvaux E, Nolz J, Olsen G, Berchtold N, Cotman C, Hecht SM, Coleman PD. Alzheimers Dement. 2017 May;13(5):510-519. doi: 10.1016/j.jalz.2016.09.003. Epub 2016 Oct 25. PMID: 27793643

  3. Zhang Y, Chevalier A, Khdour OM, Soto LM, Hecht SM. Inhibition of Human Cancer Cell Growth by Analogues of Antimycin A. Planta Med. 2017 Jun 8. doi: 10.1055/s-0043-112343. [Epub ahead of print] PubMed PMID: 28597454.

  4. Chevalier A, Khdour OM, Schmierer M, Bandyopadhyay I, Hecht SM. Influence of substituent heteroatoms on the cytoprotective properties of pyrimidinol antioxidants. Bioorg Med Chem. 2017 Mar 1;25(5):1703-1716. doi: 10.1016/j.bmc.2017.01.030. Epub 2017 Jan 23. PubMed PMID: 28189395.


2016

  1. D. Mastroeni, O. M. Khdour, E. Delvaux, J. Nolz, G. Olsen, N. Berchtold, C. Cotman, S. M. Hecht, P. D. Coleman. Nuclear but not mitochondrial-encoded OXPHOS genes are altered in aging, mild cognitive impairment, and Alzheimer's disease. Alzheimers Dement. S1552-5260(16)32932-6 (2016).

  2. A. Chevalier, Y. Zhang, O. M. Khdour, J. B. Kaye, S. M. Hecht. Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting, JACS.138(37):12009-12012 (2016)

  3. A. Chevalier, Y. Zhang, O. M. Khdour, S. M. Hecht. Selective Functionalization of Antimycin A Through an N-Transacylation Reaction, Org. Lett. 18(10):2395-2398 (2016)

  4. A. Chevalier, M. P. Alam, O. M. Khdour, M. Schmierer, P. M. Arce, C. D. Cripe, S. M. Hecht. Optimization of pyrimidinol antioxidants as mitochondrial protective agents: ATP production and metabolic stability, Bioorg. Med. Chem., 24, 5206-5220 (2016).


2015

D. Mastroeni*, O.M. Khdour,* P. M. Arce, S. M. Hecht, P. D. Coleman. Novel Antioxidants Protect Mitochondria from the Effects of Oligomeric Amyloid Beta and Contribute to the Maintenance of Epigenome Function, ACS Chem. Neurosci., 6, 588-598 (2015).


2014

M. P. Alam, O. M. Khdour, P.  M. Arce, Y. Chen, B. Roy, S. Dey, W. G. Johnston and S. M. Hecht, Cytoprotective Pyridinol Antioxidants as Potential Therapeutic Agents for Neurodegenerative and Mitochondrial Diseases.  Bioorg. Med. Chem., 22, 4935-4947 (2014).


2013

  1. O. M. Khdour, P. M. Arce, B. Roy and S. M. Hecht, An Optimized Pyrimidinol Multifunctional Radical Quencher, ACS Med. Chem. Lett., 4, 724-729 (2013).

  2. M. M. Madathil, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht, A Structurally Simplified Analogue of Geldanamycin Exhibits Neuroprotective Activity, ACS Med. Chem. Lett., 4, 953-957 (2013).

  3. D. M. Fash, O. M. Khdour, S. J. Sahdeo, R. Goldschmidt, J. Jaruvangsanti, S. Dey, P. M. Arce, V. C. Collin, G. A. Cortopassi and S. M. Hecht, Effects of Alkyl Side Chain Modification of Coenzyme Q10 on Mitochondrial Respiratory Chain Function and Cytoprotection, Bioorg. Med. Chem., 21, 2346-2354 (2013).

  4. R. Goldschmidt, P. M. Arce, O. M. Khdour, V. C. Collin, S. Dey, J. Jaruvangsanti, D. M. Fash and S. M. Hecht, Effects of Cytoprotective Antioxidants on Lymphocytes from Representative Mitochondrial Neurodegenerative Diseases, Bioorg. Med. Chem., 21, 969-978 (2013).


2012

  1. M. M. Madathil, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht, Synthesis and Biological Activities of N-(3-Carboxylpropyl)-5-amino-2-hydroxy-3-tridecyl-1,4-benzoquinone and Analogues, J. Nat. Prod., 75, 2209-2215 (2012).

  2. P. M. Arce, R. Goldschmidt, O. M. Khdour, M. M. Madathil, J. Jaruvangsanti, S. Dey, D. M. Fash, J. S. Armstrong and S. M. Hecht, Analysis of the Structural and Mechanistic Factors in Antioxidants that Preserve Mitochondrial Function and Confer Cytoprotection, Bioorg. Med. Chem., 20, 5188-5201 (2012).

  3. X. Cai, O. M. Khdour, J. Jaruvangsanti and S. M. Hecht, Simplified Bicyclic Pyridinol Analogues Protect Mitochondrial Function, Bioorg. Med. Chem., 20, 3584-3595 (2012).


2011

  1. P. M. Arce, O. M. Khdour, R. Goldschmidt, J. S. Armstrong and S. M. Hecht, A Strategy for Suppressing Redox Stress Within Mitochondria, ACS Med. Chem. Lett., 2, 608-613 (2011).

  2. O. M. Khdour, J. Lu and S. M Hecht, An Acetate Prodrug of a Pyridinol-Based Vitamin E Analogue, Pharm. Res., 28, 2896-2909 (2011).


2010

  1. J. Lu, O. M. Khdour, J. S. Armstrong and S. M. Hecht, Design, Synthesis, and Evaluation of an a-Tocopherol Analogue as a Mitochondrial Antioxidant, Bioorg. Med. Chem., 18, 7628-7638 (2010).

  2. J. S. Armstrong, O. Khdour and S. M. Hecht, Does Oxidative Stress Contribute to the Pathology of Friedreich’s Ataxia?  A Radical Question, FASEB J., 24, 2152-2163 (2010).

  3. S. J. Leiris, O. M. Khdour, Z. J. Segerman, K. S. Tsosie, J.-C. Chapuis and S. M. Hecht, Synthesis and Evaluation of Verticipyrone Analogues as Mitochondrial Complex I Inhibitors, Bioorg. Med. Chem., 18, 3481-3493 (2010).


2009

  1. J.-C. Chapuis, O. Khdour, X. Cai, J. Lu and S. M. Hecht, Synthesis and Characterization of Δlac-Acetogenins that Potently Inhibit Mitochondrial Complex I, Bioorg. Med. Chem., 17, 2204-2209 (2009).

  2. O. Khdour and E. Skibo, Quinone Methide and Cation Chemistry of Prekinamycins: 13C- Labeling, Spectral Global Fitting and In Vitro Studies, J. Org. Biomol. Chem., 7, 2140-2154 (2009).


2007

O. Khdour and E. B. Skibo, Chemistry of Pyrrolo[1,2-A]indole- and Pyrido[1,2-a]Indole-Based Quinone Methides.  Mechanistic Explanations for Differences in Cytostatic/Cytotoxic Properties. J. Org. Chem., 72, 8636-8647 (2007).


2006

O. Khdour, A. Ouyang and E. B. Skibo, Design of a Cyclopropyl Quinone Methide Reductive Alkylating Agent. 2., J. Org. Chem., 71, 5855-5863 (2006).