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In Process

  1. C.R. Simmonsǂ, T. MacCullochǂ, F. Zhang, Y. Liu, N. Stephanopoulos*, H. Yan*, “Self-Assembly of a DNA Crystal Scaffold Containing Modular Cavities for the Precise Arrangement of Macromolecules” (submitted; ǂco-first authors)

  2. H. Sainiǂ, K. Rahmaniǂ, A. Buchbergerǂ, R. Merkley, Y. Xu, J. Bernal, A. Zare, R. Ros*, M. Nikkhah*, N. Stephanopoulos*, “Reversible control of gelatin hydrogel stiffness using DNA crosslinkers” (manuscript in preparation; ǂco-first authors)


  1. A. Buchberger, C.R. Simmons, N.E. Fahmi, R. Freeman, N. Stephanopoulos*, “Hierarchical assembly of nucleic acid/coiled-coil peptide nanostructures” J. Am. Chem. Soc. 2020, 142, 1406-1416. (selected as “ACS Editor’s Choice” article)

  2. N. Stephanopoulos*, “Hybrid nanostructures from the self-assembly of proteins and DNA” Chem 2020, 6, 364-405.

  3. F.M. Fumasi, N. Stephanopoulos, J.L. Holloway*, “Reversible Control of Biomaterial Properties for Dynamically Tuning Cell Behavior” J. Appl. Polym. Sci. 2020
    (early view online:


  1. T. MacCullochǂ, A. Buchbergerǂ, N. Stephanopoulos*, “Emerging applications of peptide-oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials” Org. Biomol. Chem. 2019, 17, 1668-1682. (ǂ co-first authors)

  2. A. Stelson, M. Liu, C. Little, C. Long, N. Orloff, N. Stephanopoulos*, J. Booth*, “Label-free detection of conformational changes in switchable DNA nanostructures with microwave microfluidics” Nat. Commun. 2019, 10, 1174.

  3. Y. Xu, S. Jiang, C. Simmons, R.P. Narayanan, F. Zhang, A.-M. Aziz, H. Yan, N. Stephanopoulos*, “Tunable nanoscale cages from self-assembling DNA and protein building blocks” ACS Nano 2019, 13, 3545–3554.

  4. N. Stephanopoulos*, “Strategies for stabilizing DNA nanostructures to biological conditions” ChemBioChem 2019, 20, 2191-2197.

  5. N. Stephanopoulos*, “Peptide-DNA hybrid molecules for bioactive nanomaterials” Bioconjugate Chem. 2019, 30, 1915-1922. (selected as “ACS Editor’s Choice” article)


  1. M. Liu, S. Jiang, O. Loza, N.E. Fahmi, P. Šulc, N. Stephanopoulos*, “Rapid photo-actuation of a DNA nanostructure using an internal photocaged trigger strand” Angew. Chem. Int. Ed. 2018, 57, 9341-9345.

  2. N. Stephanopoulos*, R. Freeman*, “DNA-based materials as self-assembling scaffolds for interfacing with cells” (invited book chapter), “Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine, 1st Edition” 2018, pp. 157-175. (Elsevier)

  3. L. Avolio, D. Sipes, N. Stephanopoulos, S. Sur*, “Recreating stem-cell niches using selfassembling biomaterials” (invited book chapter), “Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine, 1st Edition” 2018, pp. 421-454. (Elsevier)


  1. C. Simmons, F. Zhang, T. MacCulloch, N.E. Fahmi, N. Stephanopoulos, Y. Liu, N. Seeman, H. Yan*, “Tuning the Cavity Size and Chirality of Self-Assembling 3D DNA Crystals” J. Am. Chem. Soc. 2017, 139, 11254-11260.

  2. D. Varun, G.R. Srinivaan, Y.-H. Tsai, H.-J. Kim, J. Cutts, F. Petty, R. Merkley, N. Stephanopoulos, D. Dolezalova, M. Marsala, D.A. Brafman*, “A Robust VintronectinDerived Peptide for the Scalable Long-term Expansion and Neuronal Differentiation of Human Pluripotent Stem Cell (hPSC)-derived Neural Progenitor Cells (hNPCs)” ActaBiomater. 2017, 48, 120-130.


  1. J.J. Greene, M.T. McClendon, N. Stephanopoulos, S.I. Stupp, C.-P. Richter, “A Bioengineered Peptide Amphiphile Nanofiber Neurograft for Facial Nerve Repair: A Comparison to Autografting using Evoked Electromyography (EMG)” (in preparation)

  2. F. Tantakitti, S. Sur, D. Carvajal, R.H. Zha, N. Stephanopoulos, B.R. Olsen, S.I. Stupp, “Orthogonal control of bioactive diffusible and matrix signals on a cell microcarrier” (in preparation)

  3. C.J. Newcomb1, S. Sur, J.M. Yu, S.S. Lee, N. Stephanopoulos, J.L. Kinol, S.I. Stupp, “Supramolecular nanofibers augment growth factor signaling by increasing lipid raft mobility” (in preparation)

  4. Z.A. Sayed, A.M. Fernando, E.J. Berns, N. Stephanopoulos, J.A. Kessler, S.I. Stupp, A.J. Matsuoka, “Re-creating a ‘stem cell niche’ in the inner ear and internal auditory canal using nanofiber based peptide amphiphile gels” (submitted)

  5. R. Freeman*, N. Stephanopoulos*, S. Sur, J. Boekhoven, S.S. Lee, S.I. Stupp, “Instructing cells with programmable DNA-peptide hybrids” (submitted) (* co-first authors)

  6. C. Rubert-Perez, N. Stephanopoulos, S.S. Lee, S. C. Newcomb, Sur, S.I. Stupp, “The Powerful Functions of Peptide-Based Bioactive Matrices for Regenerative Medicine” (invited review) Ann. Biomed. Eng. 2015, 43, 501-514.

  7. N. Stephanopoulos, R. Freeman, H.N. Scheler, S. Sur, S. Jeong, F. Tantakitti, J.A. Kessler, S.I. Stupp, “Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons” Nano Lett. 2015, 15, 603-609.


  1. A. Li, A. Hokugo, A. Yalom, E.J. Berns, N. Stephanopoulos, M.T. McClendon, L.A. Segovia, I. Spigelman, S.I. Stupp, R. Jarrahy., “A bioengineered peripheral nerve construct using aligned peptide amphiphile nanofibers” Biomaterials 2014, 35, 8780-8790.


  1. J. Sack, N. Stephanopoulos, D.C. Austin, M.B. Francis, J.S. Trimmer, “Antibody-guided photoablation of voltage-gated potassium channels” J. Gen. Physiol. 2013, 142, 315-324.

  2. N. Stephanopoulos, J.H. Ortony, S.I. Stupp, “Self-Assembly for the Synthesis of Functional Biomaterials” (invited review) Acta Materialia (special Diamond Jubilee Issue), 2013, 61, 912-930.


  1. N. Stephanopoulos, M.B. Francis, “Making New Materials from Viral Capsids” (invited book chapter) “Polymer Science: A Comprehensive Reference, 1st Edition” 2012, Vol. 9, pp. 247-266. (Elsevier)


  1. N. Stephanopoulos, M.B. Francis, “Choosing an Effective Protein Bioconjugation Strategy.” (invited review) Nat. Chem. Biol. 2011, 7, 876-884.


  1. P.G. Holder, D.T. Finley, N. Stephanopoulos, R. Walton, D.S. Clark, M.B. Francis, “Dramatic Thermal Stability of Virus-Polymer Conjugates in Hydrophobic Solvents” Langmuir 2010, 26, 17383–17388.

  2. N. Stephanopoulos, G.J. Tong, S.C. Hsiao, M.B. Francis, “Dual-Surface Modified Virus Capsids for Targeted Delivery of Photodynamic Agents to Cancer Cells” ACS Nano, 2010, 4, 6014-6020.

  3. N. Stephanopoulos*, M. Liu*, G.J. Tong, Z. Li, Y. Liu, H. Yan, M.B. Francis, “Immobilization and One-Dimensional Arrangement of Virus Capsids with Nanoscale Precision Using DNA Origami” Nano Lett. 2010, 10, 2714-2720. (* co-first authors)

  4. R.A. Miller, N. Stephanopoulos, J.M. McFarland, A.S. Rosko, P.L. Geissler, M.B. Francis, “The Impact of Assembly State on the Defect Tolerance of TMV-based Light Harvesting Arrays” J. Am. Chem. Soc. 2010, 132, 6068-6074.


  1. N. Stephanopoulos, Z.M. Carrico, M.B. Francis, “Nanoscale Integration of Sensitizing Chromophores and Porphyrins Using Bacteriophage MS2” Angew. Chem. Int. Ed. 2009, 121, 9662-9666.


  1. N. Stephanopoulos, E.O.P. Solis, G. Stephanopoulos, “Nanoscale process systems engineering: Toward molecular factories, synthetic cells, and adaptive devices” (invited perspective) AIChE J. 2005, 51, 1858-1869.