Trade-offs in the Evolution of Antibiotic Resistance

Trade-offs in the Evolution of Antibiotic Resistance

January 8, 2020

Address

727 E. Tyler St.
Tempe, AZ 85281

Location

Biodesign Institute, AL1-10/14

Date and Time

January 16, 2020, 12:00 pm (Length: 1 hour 0 minutes)

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Erdal Toprak, PhD, Assistant Professor, University of Texas Southwestern Medical Center Green Center for Systems Biology

Antimicrobial resistance is a burgeoning global health threat. Prolonged treatment times due to drug resistant pathogens increase human suffering and health care costs. Understanding the genetic changes responsible for elevated antibiotic resistance can inform novel strategies for combating drug resistance. In this seminar, I will first introduce a novel automated microbial selection device, the “morbidostat”, which we developed for studying evolution of antibiotic resistance. Following that, I will summarize our recent work where we show that antibiotic resistance evolves through an extremely rugged adaptive landscape with direct and indirect paths leading to distinct resistance peaks. I will summarize what we learned from evolving antibiotic-resistant bacteria in our lab and how we used these findings for developing a novel antibiotic. Finally, using an antibiotic efflux protein as a model system, I will try to address (i) how evolutionary constraints on multiple fitness conditions are arranged in a protein sequence and, (ii) how the rate and mechanism of protein evolution can vary under different (opposing or overlapping) selection conditions.

Hosted by Biodesign Center for Mechanisms of Evolution.