Theranostic Serpin Dressing for Wound Healing

Theranostic Serpin Dressing for Wound Healing

November 20, 2018

Address

727 E. Tyler St.
Tempe, AZ 85281

Location

Biodesign Institute, Auditorium

Date and Time

December 7, 2018, 12:00 pm (Length: 1 hour 0 minutes)

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Liqiang Zhang, Research Scientist, Biodesign Virginia G. Piper Center for Personalized Diagnostics

Large surface wounds remain a major health issue, after trauma and burns, often increasing and prolonging morbidity and mortality. With poor healing, large wounds impair skin function and increase risk of hemorrhage, infection, sepsis, and also death. Wound healing is affected by many factors, such as infection, advanced age, diabetes and other related diseases with suppressed immunity. The repair of wounds is one of the most complex biological processes in humans, and is frequently divided into three steps: hemorrhage and inflammation, new tissue generation and remodeling. Multiple inflammatory, immune and fibrotic pathways are sequentially activated in wound repair beginning from the time of injury to new tissue regeneration. Based on this understanding of the mechanisms of wound healing, numerous therapeutic methods have been developed to promote accelerated wound healing. Many diagnostic techniques, including pH sensors, have also been developed for wound healing diagnosis to allow early detection of poor healing.

However, none of these technologies to date performs both diagnostic and improved healing technologies, theranostic functions, and none are available for clinical use, thus limiting their potential. We are developing a multi-functional material to promote accelerated wound healing and to diagnose the response to treatments with minimum disturbance to the wound. We synthesized a biocompatible hydrogel membrane with a pH sensing function to provide an early diagnostic warning system to allow for early response to poor healing. This pH sensing hydrogel provides a therapeutic protein loading matrix. We load our unique immunomodulatory viral protein, Serp-1, on the diagnostic membrane surface as a new and effective therapeutic application. Using mouse models with different genetic backgrounds, we are also exploring the mechanism underlying the accelerated wound healing induced by Serp-1. The material generated in this study is a unique theranostic wound healing dressing, which has the potential to diagnose wound healing parameters (topical pH) during treatment, promote accelerated wound repair and provide a wound management feedback system.