Single Particle Cryo-EM – Breakthroughs in Structural Biology

Single Particle Cryo-EM – Breakthroughs in Structural Biology

October 13, 2016

Address

727 E. Tyler St.
Tempe, AZ 85287

Location

Biodesign Institute Auditorium

Date and Time

October 26, 2016, 3:00 pm (Length: 1 hour 0 minutes)

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Yifan Cheng, Ph.D., Associate Professor, Howard Hughes Medical Institute/University of California San Francisco

As a versatile tool in structural biology, single particle electron cryo-microscopy (cryo-EM) has been used to determine the three-dimensional (3D) structures of proteins and macromolecular complexes without the need for crystals. Recent technological breakthroughs in electron detector technologies have enabled developments of novel techniques in both data acquisition and image processing. Together, these novel technologies revolutionized single particle cryo-EM and enabled near atomic resolution structure determinations of a broad range of proteins complexes without the need of crystals. It is now feasible to use single particle cryo-EM to determine structures of protein complexes that are challenging for the more traditional X-ray crystallographic structure determination approach. This is particularly true for integral membrane proteins.

This Biological Physics seminar is presented by the ASU Center for Biological Physics, the Biodesign Center for Applied Structural Discovery and the ASU Department of Physics.