Remodeling Nuclear Architecture Allows Efficient Transport of Herpesvirus Capsids by Diffusion

Remodeling Nuclear Architecture Allows Efficient Transport of Herpesvirus Capsids by Diffusion

January 11, 2018

Address

727 E. Tyler St.
Tempe, AZ 85287

Location

Biodesign Institute AL1 10-14

Date and Time

January 12, 2018, 4:00 pm (Length: 1 hour 0 minutes)

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Presented by 

Ian Hogue, PhD, Assistant Professor, Biodesign Center for Immunotherapeutics, Vaccines and Virology

Virus particles have evolved to make themselves cargoes of intracellular trafficking mechanisms. For example, alpha herpesvirus particles recruit microtubule motors to transport up to a meter down the axons of neurons. But how do these particles, which are too large to exit via the nuclear pore complex, move a few microns to get out of the nucleus? Join herpes particles on a rollicking ride though the cell, and learn a little madcap microscopy and microrheology along the way.

Host: School of Life Sciences, Molecular and Cellular Biology Colloquium.