Protecting the Proteome in Aging and Neurodegenerative Disease

Protecting the Proteome in Aging and Neurodegenerative Disease

February 15, 2017


727 E. Tyler St.
Tempe, AZ 85287


Biodesign Institute Auditorium

Date and Time

March 1, 2017, 10:00 am (Length: 1 hour 0 minutes)

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Richard Morimoto, Ph.D., Bill and Gayle Cook Professor of Biology, Director of the Rice Institute for Biomedical Research, Northwestern University

A common feature of disease and aging is the accumulation of damaged proteins that accumulate in aggregates and amyloid species. The appearance of this molecular clutter is a consequence of protein metastability and the direct result of failure of the quality-control machinery that leads to the accumulation of these damaged proteins, which over time interferes with cellular function.

This talk examines how the cellular quality control proteostasis machinery, comprised of cell stress responses, molecular chaperones and degradative machines, responds to misfolded and aggregated proteins, the effects of aging of this process, and whether it is possible to reset the cellular machinery to restore or prevent molecular damage and degenerative diseases of aging. 

This Discovery Series event is free, open to the public and seating is on a first-come, first-served basis. Some past lectures in the series are available on demand.