Outsmarting Insecticide- and Drug-resistance Evolution

Outsmarting Insecticide- and Drug-resistance Evolution

December 3, 2019

Address

727 E. Tyler St.
Tempe, AZ 85281

Location

Biodesign Institute, Auditorium

Date and Time

December 11, 2019, 12:00 pm (Length: 1 hour 0 minutes)

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Sylvie Huijben, PhD, Assistant Professor, Center for Evolution and Medicine, School of Life Sciences, ASU

The United Nations sustainable development goals dictate a global aim to end malaria epidemics by 2030. However, antimalarial resistance has emerged to every first-line treatment and insecticide resistance is increasing for each class of available insecticides. Thus, resistance management as a strategy to end malarial epidemics is more pressing than ever. In the fight against malaria, there is an increasing understanding of the genetic background of resistance. However, we lack an understanding on how to contain resistant mutants from spreading, both locally and globally. The overall research question in the Huijben lab is: Which alternative methods most effectively slow the spread of resistance? Using an evolutionary framework, I will discuss why resistance is such a problem in current global health and propose alternatives that could reduce the selection for resistance.

This is part of the Biodesign Center for Immunotherapy, Vaccines, and Virotherapy Seminar Series.