Metabolism at the Crossroads of Inflammation and Immunity

Metabolism at the Crossroads of Inflammation and Immunity

August 24, 2017

Address

727 E. Tyler St.
Tempe, AZ 85287

Location

Biodesign Institute, Auditorium

Date and Time

September 7, 2017, 10:00 am (Length: 1 hour 0 minutes)

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Presented by Nirmal Robinson, M.Pharm, Ph.D., CECAD Research Center, University of Cologne

Using Salmonella Typhimurium as a model pathogen, the Robinson team has deciphered that molecules such as sirtuins, which lie at the interface between metabolism and immunity, play a significant role in regulating inflammation and cell-autonomous immunity. His lab has revealed that basic metabolic pathways such as glycolysis are required for phagosome maturation and clearance of pathogens by macrophages. Their findings highlight that molecules involved in maintaining metabolic homeostasis provide viable targets for developing novel biologics that could aid in treating various immune disorders. Moreover, understanding key molecular and cellular mechanisms of pathogen-host interactions would lead to new general concepts which can be exploited to treat a variety of human pathologies.

Host: Biodesign Center for Immunotherapy, Vaccines and Virotherapy