How Evolutionary and Mechanistic Insights From Budding Yeast Inform Genotype to Phenotype Maps

How Evolutionary and Mechanistic Insights From Budding Yeast Inform Genotype to Phenotype Maps

November 15, 2017

Address

727 E. Tyler St.
Tempe, AZ 85287

Location

Biodesign Institute, Auditorium

Date and Time

November 20, 2017, 3:30 pm (Length: 1 hour 0 minutes)

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Presented by Kerry Geiler-Samerotte, Ph.D., Postdoctoral Fellow, Stanford University

Identical genetic changes do not always have identical effects on phenotype. Because organisms are composed of interacting parts, the effect of perturbing any one part can offset or magnify perturbations to others, resulting in mutations with context-dependent effects on function. A major goal of the genomic age is to make predictions from genetic data about important and diverse topics, such as whether a microbial population will evolve drug resistance, whether a person will experience symptoms of a genetic disease or whether a native species will survive environmental change. Context-dependent effects of genetic change make this goal much more challenging. I believe we can make progress toward this goal by investigating and quantifying the cellular processes (for example induction dynamics of a stress-response pathway or the structure of a regulatory network) that govern how intracellular molecules interact. This presentation will cover three research projects using budding yeast to quantify the cost of protein misfolding, to reveal how natural selection obscures the mechanism by which a molecular chaperone interacts with mutant proteins and to count the number of mechanisms by which cells evolve to glucose-limitation. These studies provide evolutionary and mechanistic insights that shed light on the complex and often context-dependent mapping from genotype to phenotype.

Co-hosts: Biodesign Center for Mechanisms of Evolution and the School of Life Sciences