Genomic Insights into Ebola Virus Infection and Spread

Genomic Insights into Ebola Virus Infection and Spread

February 14, 2019

Address

727 E. Tyler St.
Tempe, AZ 85281

Location

Biodesign Institute, Auditorium

Date and Time

March 1, 2019, 12:00 pm (Length: 1 hour 0 minutes)

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Jason Thomas Ladner, PhD, Assistant Professor, Northern Arizona University, The Pathogen and Microbiome Institute

From 2014-2016, Western Africa experienced the largest Ebola virus disease (EVD) outbreak ever recorded, with >28,000 reported cases and >17,000 EVD survivors. Liberia was one of the worst-affected countries and to support Liberia’s EVD response, we established in-country advanced genomic capabilities to monitor Ebola virus (EBOV) transmission and evolution. In total, we sequenced >200 EBOV genomes that span nearly the entire Liberian outbreak, both temporally (June 2014 – April 2016) and geographically (13/15 Liberian counties). Through phylogenetic analysis of these sequences with others from neighboring countries, we were able to reconstruct the introduction and spread of EBOV in Liberia and identify the source of repeated reemergence of EVD. Through deep characterization of high-throughput sequencing data, we were also able to shed light on the dynamics of persistent EBOV infections.