Evolving Perspectives on the Genomic Instability and Fitness of Coexisting Tumor Clones

Evolving Perspectives on the Genomic Instability and Fitness of Coexisting Tumor Clones

May 9, 2018

Address

727 E. Tyler St.
Tempe, AZ 85287

Location

Biodesign Institute, Auditorium

Date and Time

May 21, 2018, 1:00 pm (Length: 1 hour 0 minutes)

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Noemi Andor, Ph.D., Instructor of Medicine and Oncology, Stanford University, School of Medicine

Scientists and oncologists lack a quantitative model that relates a cancer cell’s genomic instability to its fitness. Each of these two cell properties has its own intricate complexities. Comprehending both fully and concomitantly at clonal resolution has been a challenge. To overcome this challenge, Andor introduces CloneID, a framework that integrates measurements from different technologies, or from multispatial or longitudinal biopsies, to characterize tumor clones. Andor and colleagues leverage this framework to discern coexisting subpopulations in primary and recurrent glioblastoma haematoxylin and eosin images and to integrate clonal compositions derived from single cell RNA and DNA sequencing of human gastric cancer cell lines. Knowing which genes a given cell expresses and to which clone that same cell belongs, it is possible to begin addressing the hypothesis that a cancer cell’s genomic instability has a nonmonotonic relation to its fitness.