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Decoding Genome Evolution to Enhance Studies of Microbes and Communities

Jan 27, 2020 1:30pm | Event
Biodesign Institute, AL1-10/14

Qiyun Zhu, PhD, Postdoctoral Scholar, University of California, San Diego The art of microbiomics is morphing from amplicon toward whole-genome and metagenome studies, hence requiring novel methods and resources to couple with the rapidly growing volume and complexity of data. I strive to build a reference which accurately defines the evolutionary relationships among microbial genomes. My work advances the state-of-the-art along three dimensions: larger representation of biodiversity, more...

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Principles of Thermodynamics and Evolution for the Actions of Molecular Machines

Jan 27, 2020 3:00pm | Event
Biodesign Institute, AL1-10/14

Jason Wagoner, PhD, Laufer Center for Physical and Quantitative Biology, Stony Brook University Molecular machines are protein complexes that generate force and motion in living systems. These machines achieve impressive speeds at high efficiencies, often outperforming their macroscopic counterparts. Studying molecular machines can give unique insight into evolution, since evolutionary pressures act directly on thermodynamic properties that are easily quantified. We show that many machines...

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Large Cohort Analysis to Identify Genetic Events Associated with Outcome in Multiple Myeloma

Jan 29, 2020 12:00pm | Event
Biodesign Institute, Auditorium

Jonathan Keats, Ph.D., Assistant Professor, Director of Bioinformatics, Translational Genomics Research Institute (TGen) The Keats Lab at TGen coordinates the Multiple Myeloma Research Foundation MMRF CoMMpass Study, which is an observational clinical trial with 1143 multiple myeloma patients with whole genome, whole exome, and RNA sequencing performed on purified tumor samples at diagnosis and each subsequent relapse. The primary goal of the study is to identify distinct subtypes of the...

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The Drivers of Scientific Productivity

Jan 30, 2020 11:00am | Event
Biodesign Institute, Auditorium

Aaron Clauset, PhD, Associate Professor, University of Colorado Boulder Although meritocracy is a key organizing principle of academia, the social mechanisms that explain individual and institutional differences in scholarly outputs are poorly understood. What shapes a researcher's productivity over the course of their career? Which is a better predictor of early-career productivity and prominence, where a scientist was trained or where they currently work? Sixty years of research shows that...

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Moving Beyond Animals with Microphysiological Systems and 3D Bioprinting

Jan 31, 2020 1:30pm | Event
Biodesign Institute Auditorium

Thomas Neumann, MD, President/CEO, Nortis Bio Mark Skylar-Scott, PhD, Research Associate in the Wyss Institute for Biologically Inspired Engineering, Harvard University Begum Alaybeyoglu, PhD, Computational Biologist in the Department of Biological Engineering, Massachusetts Institute of Technology This is part of the 21st Century Research: Moving Beyond Animals Seminar Series. Reception to follow.  Register

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Atomically Precise Nanoparticles

Feb 07, 2020 10:30am | Event
Biodesign Institute, CL1-21

Thalappil Pradeep, PhD, Institute Professor, Indian Institute of Technology Madras Recent research has revealed many nanoparticles whose properties depend on the number and spatial arrangement of their constituent atoms. This distinct atom-dependence of properties is particularly noticeable in ligand protected, atomically precise clusters of noble metals. They behave like molecules and show unusual properties such as luminescence in the visible and near-infrared regions. Their molecule-like...

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Elucidating the UV-A regulon of Nostoc punctiforme and Data Mining Insights into the ebo Gene Cluster

Feb 07, 2020 3:00pm | Event
Biodesign Institute, Auditorium

Kevin Klicki, Molecular and Cellular Biology Graduate Student This is part of the Molecular and Cellular Biology Seminar Series.

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Moving Beyond Animals through Bioengineering

Feb 28, 2020 1:30pm | Event
Biodesign Institute, Auditorium

Mehdi Nikkhah, PhD Assistant Professor of Biomedical Engineering at the School of Biological and Health Systems Engineering, Arizona State University Brian Niemeyer, PhD, Postdoctoral Fellow in the Benam Lab for Translational and Multidisciplinary Lung Microengineering, University of Colorado, Anschutz Medical School Himanshu Kaul, D.Phil., Post-Doctoral Fellow at Michael Smith Foundation for Health Research, The University of British Columbia, School of Biomedical Engineering,...

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Moving Beyond Animal Models through In Vitro and In Silico Toxicity Testing

Mar 27, 2020 1:30pm | Event
Biodesign Institute, Auditorium

Erin Hill, President, Institute for In Vitro Sciences Michael Lawless, PhD, Senior Principal Scientist, Simulations Plus, Inc. This is part of the 21st Century Research: Moving Beyond Animals Seminar Series. Reception to follow. Register

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Moving Beyond Animal Models in the Neurosciences and Infectious Disease Research

Apr 24, 2020 1:30pm | Event
Biodesign Institute, Auditorium

Cheryl Nickerson, PhD, Professor, School of Life Sciences, Biodesign Center for Fundamental and Applied Microbiomics Lena Smirnova, PhD, Research Associate, Director of the Systems Biology and Microphysiological Systems Program & Director of Education, Johns Hopkins University Center for Alternatives to Animal Testing (CAAT) Cleber Trujillo, PhD, Associate Project Scientist in the Field of Neuroscience and Stem Cells, University of California, San Diego, School of Medicine, Department...

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