Chemical and enzymatic strategies for complex molecule synthesis

Chemical and enzymatic strategies for complex molecule synthesis

January 22, 2021

Location

Zoom

Date and Time

March 25, 2021, 12:00 pm (Length: 1 hour 0 minutes)

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Kyle Biegasiewicz, PhD
Biodesign Center for Molecular Design and Biomimetics

presents: Chemical and enzymatic strategies for complex molecule synthesis

The chemical synthesis of structurally and stereochemically complex molecules is a focal point of the pharmaceutical, agriculture and materials industries.  In an effort to optimize the desired parameters affiliated with their synthesis (step, atom, redox economies) we rely heavily upon the discovery of catalysts that can accomplish early and late-stage bond construction under mild conditions and with broad functional group tolerance.  Moreover, a premium is placed on the development of sustainable catalysts that can accomplish these goals with little to no waste generation.   

This talk will feature a combination of chemical and enzymatic strategies for achieving catalytic C-C bond formation.  It will be divided into three segments including 1) the development of an organocatalytic hydroxymethylation protocol and its application in the total synthesis of the apoptosis inducer, (-)-rasfonin, 2) photoexcitation of flavoenzymes for stereoselective C-C bond formation, and 3) the development of a class of terpene cyclases using oxyanion hole catalysis in hydrolases.

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This is part of Biodesign Center for Sustainable Macromolecular Materials and Manufacturing Spring 2021 seminar series.