Publications

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2020

 

  1. J. Veldhuizen, J. Cutts, D. Brafman, R. Migrino, M. Nikkhah*,”Development of a Stem Cell-Derived Human Myocardium in a Microengineered Tissue-Chip Platform”, Submitted, (In Review),  (2020).

  2. H. Saini, J. Veldhuizen, A. Zare, M. Alaam, C. Silva, D. Truong, G. Mouneimne, J. LaBaer, R. Ros, M. Nikkhah*, “The Role of Tumor-Stroma Interactions on Desmoplasia and Tumorigenicity within a Microengineered 3D Platform”, Biomaterials, Accepted, In Press, (2020). 

  3. A. Pal, C. Smith, J. Palade, S. Nagaraju, B. A. Benedetto, J. Kilbourne, A. Rawls, J. Wilson-Rawls, B. Vernon*, M. Nikkhah*, “Poly(N-isopropylacrylamide)-based Dual-Crosslinking Biohybrid Injectable Hydrogels for Vascularization”, Acta Biomaterialia, Accepted, In Press, (2020)

  4. N. Karamanova, S. Truran, J. Madine, V. Weissig, J. Veldhuizen, M. Nikkhah, H. A. Davies, G. E. Serrano, M. Hansen, W. Zhang, D. A. Franco, T. G. Beach, R. Q. Migrino*, “Endothelial Immune Activation by Amyloidogenic Medin and Its Potential Role in Aging-Related Cerebrovascular Disease”, Journal of American Heart Association (JAHA)9 (2), 1-13, 2020. 


2019

  1. D. Truong, A. Kratz, J. Park, E. S. Barrientos, H. Saini, T. Nguyen, B. A. Pockaj, G. Mouneimne, J. LaBaer, M. Nikkhah*, “Human Organotypic Microfluidic Tumor Model Permits Investigation of the Interplay Between Patient-derived Fibroblasts and Breast Cancer Cells”, Cancer Research, 7(12), 3139-3151, 2019.

  2. A. Singh*, M. Nikkhah*, N Annabi*, “Editorial: Biomaterials, Cells, and Patho-physiology: Building Better Organoids and On-Chip Technologies”, Biomaterials, 198, 1-2, 3, 2019. 

  3. J. Veldhuizen, R. Q. Migrino, M. Nikkhah*, “Three Dimensional Microengineered Models of Human Cardiac Diseases” Journal of Biological Engineering13:29, 1-12, 2019.

  4. S. Talebian, M. Mehrali, N. Taebnia, C. P. Pennisi, M. Hasany, M. Nikkhah, M. Akbari, G. Orive, Alireza Dolatshahi-Pirouz*, “Self-healable hydrogels: The next big thing in tissue engineering”, Advanced Sciences, 6:6, 1-47, 2019. 

  5. Navaei, K. Rahmani, R. Ros, R. Q. Migrino, B. C. Willis,  M. Nikkhah*, “The Influence of Electrically Conductive and Non-conductive Nanocomposit Scaffolds on Maturation and Excitability of Engineered Cardiac Tissues”, Biomaterial Science7, 585-595, 2019. [2019 Biomaterials Science Emerging Investigators Issue]

  6. D. Truong, R. Fiorelli, E. S. Barrientos, E. L. Melendez, N. Sanai, S. Mehta*, M. Nikkhah*, “A Three Dimensional (3D) Organotypic Microfluidic Model for Glioma Stem Cells-Vascular Interactions”, Biomaterials, 198, 63-77, 2019. [Special Issue on Biomaterials and Bioengineering Innovations for Ex Vivo Tissue Chip Model Development]


2018

  1. A. R Donaldson, P. B. Narayanan, M. Nikkhah, L. Hall, A. Khademhosseini A. Ghaemmaghami*, “Photocrosslinkable Gelatin Hydrogels Modulate the Production of the Major Pro-Inflammatory Cytokine, TNF-α, by Human Mononuclear Cells”, Frontiers in Bioengineering and Biotechnology, Biomaterials Section6, Article 116, 2018.  

  2. H. Saini, K. Rahmani, C. Silva, M. Allam, G. Mouneimne, R. Ros, M. Nikkhah*, “The Role of Desmoplasia and Stromal Fibroblasts on Anti-Cancer Drug Resistance in a Microengineered Tumor Model”, Cellular and Molecular Bioengineering (CMBE)., 11, 419-433, 2018. [Special Issue on BMES/CMBE Young Innovator Awards]

  3. S. Nagaraju#, D. Truong#, G. Mouneimne, M. Nikkhah*, "Microfluidic Tumor-Vascular Model to Study Breast Cancer Cell Invasion and Intravasation,", Advanced Healthcare Materials., 7, 1701267, 1-12, 2018. [Highlighted in Advanced Sciences News]

  4. A. Pal, B. Vernon, M. Nikkhah*, "Therapeutic Neovascularization Promoted by Injectable Hydrogels,", Bioactive Materials, 3, 389-400, 2018.


2017

 

  1. N. Peela#, E. Barrientos#, D. Truong, G. Mouneimne, M. Nikkhah*, “Effect of Suberoylanilide Hydroxamic Acid (SAHA) on Breast Cancer Cells Within a Tumor-stroma Microfluidic Model”, Integrative Biology, 9, 988-999, 2017.

  2. S. Liu, A. Navaei, X. Meng, M. Nikkhah* & J. Chae*, “Wireless Passive Stimulation of Engineered Cardiac Tissues”, ACS Sensors, 2, 1006-1012, 2017.

  3. R. Q. Migrino, H. Davies, S. Truran, N. Karamanova, D. A. Franco, T. Beach, G. Serrano, D. Truong, M. Nikkhah, Jill“Amyloidogenic Medin Induces Endothelial Dysfunction and Vascular Inflammation through the Receptor for Advanced Glycation Endproducts”, Cardiovascular Research, 113, 1389- 1402, 2017.

  4. N. Peela#, D. Truong#, H. Saini#, H. Chu, S. Mashaghi, S. L. Ham, S. Singth, H. Tavana, B. Mossadegh, M. Nikkhah*, “Advanced Biomaterials and Microengineering Technologies to Recapitulate the Stepwise Process of Cancer Metastasis”, Biomaterials, 113, 176-207, 2017. [Among the Most Downloaded Articles in Biomaterials]

  5. A. Memic, A. Navaei, B. Mirani, J. A Cordova, M. Aldhahri, A. Dolatshahi-Pirouz, M. Akbari, M. Nikkhah*, “Bio-Printing Technologies for Disease Modeling”, Biotechnology Letters133, 1279-1290, 2017.

  6. D. Pedde, B. Mirani, A. Navaei, T. Styan, S. Wong, M. Mehrali, A. Thakur, M. K. Mohtaram, A. Bay, A. Dolatshahi, M. Nikkhah, S. Willerth, M. Akbari*, “Emerging Biofabrication Strategies of Complex Tissue Constructs”, Advanced Materials, 39, 1-27, 2017. 

  7. A. Navaei, N. Moore, R. Sullivan, D. Truong, R. Migrino, and M. Nikkhah*, “Electrically Conductive Hydrogel-Based Micro-Topographies for the Development of Organized Cardiac Tissues”, RSC Advances, 7: 3302-3312, 2017.

  8. M. Mehrali, A. Thakur, C. Pablo, S. Talebian, A. Arpanaei, M. Nikkhah, A. Dolatshahi*, “Nanoreinforced Hydrogels for Tissue Engineering: Biomaterials that are Compatible with Load-Bearing and Electroactive Tissues”, Advanced Materials, 29, 1-26, 2017. 

 


2016

 

  1. D. Truong, J. Puleo, A. Llave, G. Mouneimne, R. D. Kamm, and M. Nikkhah*, “Breast Cancer Cell Invasion into a Three Dimensional Tumor-Stroma Microenvironment,” Scientific Reports, 6: 34094, 2016. [Highlighted on Scientific Reports Editor’s Choice]

  2. A. Navaei, H. Saini, W. Christenson, R. Sullivan, R. Ros, and M. Nikkhah*, “Gold Nanorod-Incorporated Gelatin-Based Conductive Hydrogels for Engineering Cardiac Tissue Constructs”, Acta Biomaterialia, 41: 133-146, 2016. [Acta Biomaterialia Best Student Paper Award]

  3. M. Kharaziha, A. Memic, M. Akbari, D. Brafman, and M. Nikkhah*, “Nano-Enabled Approached for Stem Cell-Based Cardiac Tissue Engineering”, Advanced Healthcare Materials5: 1533-1553, 2016. [Front Piece Cover]

  4. S. R. Shin, C. Zihlmann, M. Akbari, P. Assawes, L. Cheung, K. Zhang, V. Manoharan, Y. S. Zhang, M. Yüksekkaya, K. Wan, M. Nikkhah, M. R. Dokmeci, S. Tang, A. Khademhosseini, “Conductive Reduced Graphene Oxide-GelMA Hydrogels as Scaffolding Materials for Cardiac Tissue Engineering”, Small, 12, 3677-3689, 2016.

  5. A. Navaei#, D. Truong#, J. Heffernan, J. Cutts, D. Brafman, R. Sirianni, B. Vernon, and M. Nikkhah*, “PNIPAAm-based Biohybrid Injectable Hydrogel for Cardiac Tissue Engineering”, Acta Biomaterialia, 32: 10-23, 2016. [#Equal Contribution]

  6. N. Peela#, F. S. Sam#, W. Christenson, D. Truong, A. W. Watson, G. Mouneimne, R. Ros, M. Nikkhah*, “A Three Dimensional Micropatterned Tumor Model for Breast Cancer Cell Migration Studies”, Biomaterials, 81: 72-83, 2016. [#Equal Contribution].

 


2015

 

  1. H. Saini, A. Navaei, A. Van Putten , M. Nikkhah*, “Three Dimensional Cardiac Micro-Tissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts”, Advanced Healthcare Materials 4: 1961-1971, 2015

  2. J. Cutts, M. Nikkhah, D. A. Brafman, “Biomaterial Approaches for Stem Cell-Based Myocardial Tissue Engineering”, Biomarkers Insight, Volume 10, S1,  pp. 77-90, 2015.

  3. A. Gaharwar#, M. Nikkhah#, S. Sant, A. Khademhosseini “Anisotropic Poly (glycerol sebacate)-poly (ε-caprolactone) Electrospun Fibers Promote Endothelial Cell Guidance”, Biofabrication, 7: 015001, 2015. [#Equal Contribution].

  4. D. Brafman, S. Campbell, A. Q. Lam, J. J. Kim, M. Nikkhah, S. Stabenfeldt“Editorial: Stem Cell Biology”, Biomarkers Insight, Volume 10,  pp. 133-137, 2015.

 


2014

 

  1. A. Paul, A.Hasan, H. Al Kindi, A. Gaharwar, V. T. S. Rao, M. Nikkhah, S. R. Shin, M. R. Dokmeci, D. S-Tim and A. Khademhosseini, “Injectable Graphene Oxide/DNAVEGF Based Hydrogel for Vasculogenesis and Cardiac Repair”, ACS Nano, Volume 8, Issue 8, pp. 8050-8062, 2014

  2. S. R. Shin#, B. Aghaei#, S. N. Topkaya, M. Nikkhah, S. B. Kim, S. M. Kim, M. R. Dokmeci, S. Tang, and A. Khademhosseini “Layer-by-Layer Assembly of 3D Tissue Constructs with Functionalized Graphene”, Advanced Functional Materials, Volume 24, Issue 39, pp. 6136-6144, 2014

  3. A. H. Najafabadi, A. Tamayol, N. Annabi, M. Ochoa, P. Mostafalu, M. Akbari, M. Nikkhah, M. R. Dokmeci, S. Sonkusale, B. Ziaie and A. Khademhosseini, “Electrospun Polymers as a Platform for the Fabrication of Biodegradable, Elastic, and Flexible Electronics”, Advanced Materials, Volume 26, Issue 33, pp. 5823-5830, 2014

  4. M. Kharaziha#, S. Shin#, M. Nikkhah, S. N. Topkaya, N. Masoumi, M. R. Dokmeci, and A. Khademhosseini, “Carbon Nanotube Based PGS/Gelatin Nanofibrous scaffolds for Cardiac Tissue Engineering”, Biomaterials, Volume 35, Issue 26, pp. 7346-7354, 2014

  5. L. E. Bertassoni, M. Cecconi, V. Manoharan, M. Nikkhah, J. Hjortnaes, A. L. Cristino, G. Barabaschi, D. Demarchi, M. Dokmeci, Y. Yang and A. Khademhosseinib “Engineering of Microchannel Networks via Bioprinting for Prevascularization of Hydrogels for Tissue Engineering”, Lab on a Chip, Volume 14, Issue 13, pp. 2202-2211, 2014.

  6. A. Dolatshahi, M. Nikkhah, A. Gaharwar, B. Hashmi, E. Guermani, D. Ingber and A. Khademhosseini, “A Combinatorial Cell-laden Gel Microarray for Inducing Osteogenic Differentiation of Human Mesenchymal Stem Cells”, Scientific Reports, Volume 4, 2014. 

 


2013

 

  1. M. Nikkhah, I. G. Arcibal, M. R. Dokmeci, and A. Khademhosseini, “Editorial; Research Highlights”, Lab on a Chip, Volume 13, issue 23, pp. 4499-4502, 2013.

  2. C. Cha, P. Soman, W. Zhu, M. Nikkhah, G. C. Unal, S. Chen, and A. Khademhosseini, “Structural Reinforcement of Cell-Laden Hydrogels with Microfabricated Three Dimensional Scaffolds”Biomaterials Science,  Volume 2, Issue 5, pp. 703–709, 2013.

  3. M. Kharaziha#, M. Nikkhah#, S. Shin, N. Annabi, N. Masoumi, A. Gaharwar, G. C. Unal and A. Khademhosseini, “PGS:Gelatin Nanofibrous Scaffolds with Tunable Mechanical and Structural properties for Engineering Cardiac Tissues”, Biomaterials, Volume 34, Issue 27, pp. 6355–66, 2013.  [#Equal Contribution]. [Among the Most Downloaded Articles in Biomaterials]

  4. P. Hassanzadeh#, M. Kharaziha#, M. Nikkhah, S. Shin, J. Jin, S. He, W. Sun, M. R. Dokmeci, A. Khademhosseini and M. Rolandi, “Micropatterned Chitin Nanofiber Flexible Substrates for Tissue Engineering”, Journal of Materials Chemistry B, Volume 1, Issue 34, pp. 4217-24 , 2013. [Front Piece Cover]

  5. M. Nikkhah, J. S. Strobl, V. Srinivasaraghavan, and M. Agah “Isotropically-etched Silicon Microarrays for Rapid Breast Cancer Cell Capture ”, IEEE Sensors Journal, Volume 13, Issue 3, pp. 1125-1132, 2013.

  6. N. Annabi, K. Tsang, S. M. Mithieux, M. Nikkhah, A. Ameri, A. Khademhosseini, A. S. Weiss, “Highly Elastic Micropatterned Hydrogel for Engineering Functional Cardiac Tissue”, Advanced Functional Materials, Volume 23, Issue 39, pp. 4949, 2013.

  7. S. Shin, S. Jung, M. Zalabany, K. Kim, P. Zorlutuna. S. B. Kim, M. Nikkhah, M. Khabiry, M. Azize, J. Kong, K. Wan, T. Palacios, M. Dokmeci, H. Bae, X. Tang and A. Khademhosseini, “Carbon Nanotube Embedded Hydrogel Sheets for Engineering Functional Cardiac Tissues and Bioactuators”, ACS NanoVolume 7, Issue 3, pp. 2369-80, 2013.

 


2012

 

  1. M. Nikkhah, N. Eshak, M. Castello, N. Annabi, K. Kim. P. Zorlutuna, A. Dolatshahi, F. Edalat, H. Bae, Y. Yang and A. Khademhosseini, “Directed Endothelial Cell Morphogenesis in Micropatterned Gelatin Methacrylate Hydrogels”, Biomaterials, Volume 33, Issue 35, pp. 9009-18, 2012. 

  2. M. Nikkhah, F. Edalat, S. Maouchehri and A. Khademhosseini, “Engineering Microscale Topographies to Control the Cell–Substrate Interface”, Biomaterials, Volume 33, Issue 21, pp. 5230-46, 2012

  3. L. Ngyuen#, N. Annabi#, M. Nikkhah, H. Bae, L. Binan, S. Park, Y. Kang, Y. Yang and A. Khademhosseini “Vascularized Bone Tissue Engineering: Approaches for Potential Improvement”, Tissue Engineering Part B Reviews, Volume 18, Issue 5, pp. 363-82, 2012.

  4. P. Zorlutuna, N. Annabi, G. Camci-Unal, M. Nikkhah, J. M. Cha, J. Nichol, A. Manbachi, H. Bae, S. Chen and A. Khademhossein, “Microfabricated Biomaterials for Engineering 3D Tissues”, Advanced Materials, Volume 24, Issue 14, pp. 1782-1804, 2012.

 


2011

 

  1. A. Dolatshahi, M. Nikkhah, K. Kolind, M. R. Dockmeci and A. Khademhosseini, “Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions”, Journal of Functional Biomaterials, Volume 2, Issue 3, pp. 88-106, 2011.

  2. M. Nikkhah, J. S. Strobl, Eva M. Schmelz and M. Agah, “MCF10A and MDA-MB-231 Human Breast Basal Epithelial Cell Co-Culture in Silicon Microarrays”, Biomaterials, Volume 32, Issue 30, pp. 7625-7632, 2011.

  3. M. Nikkhah, J. S. Strobl, Eva M. Schmelz and M. Agah, “Evaluation of the Influence of Growth Medium Composition on Cell Elasticity”, Journal of Biomechanics, Volume 44, Issue 4, pp. 762-766, 2011.

 


2005-2010

 

  1. M. Nikkhah, J. S. Strobl, R. De Vita, and M. Agah, “The Cytoskeletal Organization of Breast Carcinoma and Fibroblast Cells Inside Three Dimensional (3-D) Isotropic Silicon Microstructures”, BiomaterialsVolume 31, Issue 16, pp. 4552-4561, 2010[Front Piece Cover]

  2. J. S. Strobl#, M. Nikkhah#, and M. Agah, “Actions of the Anti Cancer Drug Suberoylanilide Hydroxamic Acid (SAHA) on Human Breast Cancer Cytoarchitecture in Silicon Microstructures”, BiomaterialsVolume 31, Issue 27, pp. 7043-7050, 2010.[# Equal Contribution].

  3. S. Narayanan, M. Nikkhah, S. Strobl, and M. Agah, “Analysis of the Passivation Layer by Testing and Modeling a Cell-Impedance Micro-Sensor”, Sensors and Actuators A, Physical, Volume 159, Issue 2, pp. 241-247, 2010.

  4. M. Nikkhah, J. S. Strobl, B. Peddi and M. Agah, “Cytoskeletal Role in Differential Adhesion Patterns of Normal Fibroblasts and Breast Cancer Cells inside Silicon Microenvironments”, Biomedical Microdevices, Volume 11, Issue 3, pp. 585-595, 2009.

  5. M. Nikkhah, J. S. Strobl and M. Agah, “Attachment and Response of Human Fibroblast and Breast Cancer Cells to Three Dimensional Silicon Microstructures of Different Geometries”, Biomedical Microdevices, Volume 11, Issue 2, pp. 429-441, 2009.

  6. K. R. Muske, H. Ashrafiuon, S. Nersesov and M. Nikkhah, “Optimal Sliding Mode Cascade Control for Stabilization of Underactuated Nonlinear Systems”ASME Journal of Dynamic Systems, Measurement and ControlVolume 134, Issue 2, Paper # 021020.

  7. M. Nikkhah, H. Ashrafiuon and F. Fahimi, “Robust Control of Underactuated Bipeds Using Sliding Modes”, Robotica, Volume 25, Issue 3, pp. 367-374, 2007. 

  8. S. J. Kadlecek, K. Emami, M. C. Fischer, M. Ishii, J. S. Yu, J. M. Woodburn, M. Nikkhah, et. al., “Imaging physiological parameters with hyperpolarized gas MRI”, Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 47, pp. 187-212, 2005.