Publications

Books

  1. Hartwell, L.H., Hood, Leroy, Goldberg, Michael L., Reynolds, Ann E., Silver, Lee M., Veres, Ruth C. 1999 Genetics –From Genes to Genomes. McGraw Hill

  2. Brewer, Bonita J., Friedman, Jan M., Hartwell, L. H., Manoil, Colin C., Sibley, Carol, Toriello, Helga V. 1993 Solving The Puzzle: Careers in Genetics The Genetics Society of America

2006

  1. Hartwell, L., Mankoff, D, Paulovich, A, Ramsey, S., Swisher, E. 2006 Cancer biomarkers: a systems approach Nature Biotechnology 24(8): 905-908

2005

  1. Aebersold, R, Anderson, L., Caprioli, R., Druker, B., Hartwell, L., Smith, R 2005 Perspective: a program to improve protein biomarker discovery for cancer. J Proteome Res Jul-Aug; 4(4):1104-09

2004

  1. *Hartman, J.L. and Tippery, N.P. 2004 Systematic quantification of gene interactions by phenotypic array analysis Genome Biology 5:R49

  2. Hartwell, L. 2004 Robust Interactions Science 303: 774 (5659)

2003

  1. Etzioni, R., Urban, N., Ramsey, S., McIntosh, M., Schwartz, S., Reid, B., Radich, J, Anderson, G, Hartwell, L. 2003

  2. The Case for Early Detection Nature Reviews / Cancer Vol 3: 243-252

2001

  1. Hartman, J., Hartwell, L.H., Garvik, B. 2001 Principles for the Buffering of Genetic Variation. Science 291:1001-1004

  2. Emili, A., Schieltz, D.M., Yates, J.R., Hartwell, L.H. 2001. Dynamic Interaction of DNA Damage Checkpoint Protein Rad53 with Chromatin Assembly Factor Asf1. Molecular Cell 7: 13-20.

  3. *Foss, E.J. 2001. Tof1p Regulates DNA Damage Responses During S Phase in Saccharomyces cerevisiae Genetics 157: 567-577

 

Before 2000

  1. Simon, J.A., Szankasi, P., Nguyen, D.K., Ludlow, C., Dunstan, H.M., Roberts, C.J., Jensen, E.L., Hartwell, L.H., Friend, S.H. 2000. Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae. Cancer Res. 60(2): 328-333.

  2. *Foss, E. J. 2000 Is Rad9p Upstream or Downstream fromMec1p? Cold Spring Harbor Symposia on Quantitative Biology, Vol LXV

  3. Hartwell, L.H., Hopfield, J. J., Leibler, S., Murray, A.W. 1999 From molecular to modular cell biology. Nature 402 supplement (6761): C47-C52.

  4. Marton, M. J., DeRisi, J. L., Bennett, H. A, Iyer, V. R., Meyer, M. R., Roberts, C. J., Stoughton, R., Burchard, J., Slade, D., Dai, H., Bassett, D. E., Jr., Hartwell, L. H., Brown, P. O., Friend, S.H. 1998 Drug target validation and identification of secondary drug target effects using DNA microarrays. Nature Medicine 4(11): 1293-1301.

  5. Nurse, P., Masui, Y., Hartwell, L. 1998 Understanding the cell cycle. Nature Medicine 4(10):1103-1106.

  6. * Emili, A. 1998. MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Molecular Cell 2: 183-189

  7. Paulovich, A. G., Armour, C. D. and Hartwell, L. H. 1998. The Saccharomyces cerevisiae RAD9, RAD17, RAD24, and MEC3 genes are required for tolerating irreparable, UV-induced DNA damage. Genetics 150(1):75-93.

  8. Brown, P. O. and Hartwell, L. H. 1998. Genomics and human disease - variations on variation. Nature Genetics 18: 91- 93.

  9. Hartwell, L. H., Szankasi, P. Roberts, C. J., Murray, A. W., and Friend, S. H. 1997. Integrating Genetic Approaches into the Discovery of Anti-cancer drugs. Science 278(5340): 1064-1068.

  10. Schrick, K, Garvik, B, and Hartwell, L. 1997. Mating in Saccharomyces cerevisiae: Pheromone receptor and G protein but not components of the MAP kinase cascade are required for response to pheromone. Genetics147: 19-32.

  11. Hartwell, L. 1997. Theoretical biology: A robust view of biochemical pathways. Nature 387(6636): 855, 857. Toczyski, D.P., Galgoczy, D.J., and Hartwell, L.H. 1997. CDC5 and CKII control adaptation to the yeast DNA damage checkpoint. Cell 90(6):1097-1106.

  12. Wooden, JM, Hartwell, LH, Vasquez, B. and Sibley, CH. 1997. Analysis in yeast of antimalaria drugs that target the dihydrofolate reductase of Plasmodium falciparum. Molec. & Biochem. Parasitology. 85: 25-40.

  13. Paulovich, A. G., Toczyski D. P. and Hartwell, L. H. 1997. When Checkpoints Fail. Cell 88(3): 315-321. Dorer, R, Boone, C, Tyler, K, Kim, J, and Hartwell, L. 1997. Genetic Analysis of Default Mating Behavior in Saccharomyces cerevisiae. Genetics 146: 39-55.

  14. Paulovich, M, Margulies, B, Garvik, B.M., and Hartwell, l. 1997. RAD9, RAD17, AND RAD24 are required for S phase regulation in S. cerevisiae in response to DNA damage. Genetics 145: 45-62.

  15. Prychiak, Peter, M. and Hartwell,. L. 1996. AKR1 encodes a candidate effector of the Gbg complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction. Molec. & Cell Biol. 16: 2614-26.

  16. Garvik, B., Carson, M. and Hartwell, L. 1995. Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell Biol. 15:6128-38.

  17. Dorer, R., Pryciak, P., Schrick, K., and Hartwell, L. 1995. The induction of cell polarity by pheromone in S. cerevisiae. Harvey Lectures.

  18. Paulovich, A.G. and Hartwell, L.H. 1995. A checkpoint regulates the rate of progression through S phase in S. ceevisiae in response to DNA damage. Cell 82: 841-7.

  19. Dorer, R., Pryciak, P.M., and Hartwell, L.H. 1995. Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients. J. Cell Biol. 131: 845-861.

  20. Hartwell, L.H. 1995. Introduction to cell cycle controls. Cell Cycle Control: A Practical Approach. Ed. C. Hutchison and D.M. Glover. Oxford University Press.

  21. Hartwell, L., Weinert, T., Kadyk, L., and Garvik, B. 1994. Cell cycle checkpoints, genomic integrity, and cancer. Cold Spring Harbor Symposia Quant. Biol. 59: 259-264.

  22. Hartwell, L.H. 1994. Forbeck Cancer Forum on Cell Cycle Checkpoints. Clinical Cancer Research 1(9):1067, 1995 Sep.

  23. Hartwell, L. H. and Kastan M. B. 1994. Cell cycle control and cancer. Science 266: 1821-1828.

  24. Weinert, T. A., Kiser, G. L. and Hartwell, L. H. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8: 652-665.

  25. Brown, M. T., Goetsch, L. and Hartwell, L. H. 1993. MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. J. Cell Biol. 123: 387-403.

  26. Hartwell, L. H. 1993. Getting started in the cell cycle. The early days of yeast genetics. M. N. Hall and P. Linder. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.

  27. Weinert, T. A. and Hartwell, L. H. 1993. Cell cycle arrest of cdc mutants and specificity of the RAD9 checkpoint. Genetics 134: 63-80.

  28. Kadyk, L. C. and Hartwell, L. H. 1993. Replication-dependent sister chromatid recombination in rad1 mutants of Saccharomyces cerevisiae. Genetics 133: 469-487.

  29. Hartwell, L. H. 1992. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells. Cell 71: 543-546.

  30. Kadyk, L. C. and Hartwell, L. H. 1992. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae. Genetics 132: 387-402.

  31. Hartwell, L. H. 1992. Bringing the basic scientist into human disease research. Mol. Biol. Cell 3: 837.

  32. Hartwell, L. H. 1992. Role of yeast in cancer research. Cancer 69: 2615-2621.

  33. Hartwell, L. H. 1991. Twenty-five years of cell cycle genetics. Genetics 129: 975-980.

  34. Neiman, P.E., and Hartwell, L.H. 1991. Malignant instability. Workshop on Genetic Instability and its Role in Carcinogenesis sponsored by the Programs in Molecular Medicine of the Fred Hutchinson Cancer Research Center and the University of Washington. New Biol. 3(4): 347-251.

  35. *Konopka, J. B. and Jenness, D. D. 1991. Genetic fine-structural analysis of the Saccharomyces cerevisiae -pheromone receptor. Cell Regulation 2: 439-452.

  36. Jackson, C. L., Konopka, J. B. and Hartwell, L. H. 1991. S. cerevisiae -pheromone receptors activate a novel signal transduction pathway for mating partner discrimination. Cell 67: 389-402.

  37. Brown, M., Garvik, B., Hartwell, L., Kadyk, L., Seeley, T. and Weinert, T. 1991. Fidelity of mitotic chromosome transmission. Cold Spring Harbor Symposia on Quantitative Biology, Volume LVI. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, pp. 359-365.

  38. Hartwell, L. H. and Weinert, T. A. 1991. Genetic control of mitotic fidelity and its relation to cancer. Origins of human cancer: A comprehensive review. Joan Brugge, Tom Curran, Ed Harlow and Frank McCormick, eds. Cold Spring Harbor Laboratory Press, pp. 45-49.

  39. Weinert, T. A. and Hartwell, L. H. 1990. Characterization of RAD9 of Saccharomyces cerevisiae and evidence its function acts posttranslationally in cell cycle arrest after DNA damage. Mol. Cell. Biol. 10: 6554-6564.

  40. Jackson, C. L. and Hartwell, L. H. 1990. Courtship in Saccharomyces cerevisiae: Both cell types choose mating partners by responding to the strongest pheromone signal. Cell 63: 1039-1051.

  41. Jackson, C. L. and Hartwell, L. H. 1990. Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating. Mol. Cell. Biol. 10: 2202-2213.

  42. Hartwell, L. and Weinert, T. 1989. Checkpoints: Controls that ensure the order of cell cycle events. Science 246: 629- 634.

  43. Weinert, T. and Hartwell, L. 1989. Control of G2, delay by the RAD9 gene of Saccharomyces cerevisiae. J. Cell Sci. Suppl. 12: 145-148.

  44. Burke, D., Gasdaska, P., and Hartwell, L. H. 1989. Dominant effects of tubulin overexpression in Saccharomyces cerevisiae. Mol. Cell. Biol. 9: 1049-1059.

  45. Konopka, J., Jenness, D., Hartwell, L. H. 1988. The C-terminus of the Saccharomyces cerevisiae -pheromone receptor mediates an adaptive response to pheromone. Cell 54: 609-620.

  46. Cross, F., Hartwell, L. H., Jackson, C. and Konopka, J. B. 1988. Conjugation in Saccharomyces cerevisiae. Ann. Rev. Cell Biol. 4: 429-457.

  47. Weinert, T. A., and Hartwell, L. H. 1988. The RAD9 gene controls the cell cycle response to DNA damage in Saccharomyces cerevisiae. Science 241: 317-322.

  48. Weinert, T. A., and Hartwell, L. H. 1988. RAD9 gene function controls the cell-cycle response to DNA damage in the yeast Saccharomyces cerevisiae. In: Cell cycle control in eukaryotes. Ed. David Beach, Claudio Basilico and John Newport. Cold Spring Harbor Press, pp. 151-154.

  49. Koshland, D. and Hartwell, L. H. 1987. The structure of sister minichromosome DNA before anaphase in Saccharomyces cerevisiae. Science 238: 1713-1716.

  50. Koshland, D., Rutledge, L., Fitzgerald-Hayes, M., and Hartwell, L. 1987. A genetic analysis of dicentric minichromosomes in Saccharomyces cerevisiae. Cell 48: 801-812.

  51. Jenness, D., Goldman, B. and Hartwell, L. H. 1987. Saccharomyces cerevisiae mutants unresponsive to -factor pheromone: -factor binding and extragenic suppression. Mol. Cell. Biol. 7: 1311-1319.

  52. Jenness, D. D., Burkholder, A.C. and Hartwell, L. H. 1986. Hormonal control of cell division in Saccharomyces cerevisiae. In: Cell cycle and oncogenes, 37th Mosbach Colloquium, Ed. W. Tanner and D. Gailwitz. Springer- V erlag.

  53. Meeks-Wagner, D., Wood, J. S., Garvik, B. and Hartwell, L. H. 1986. Isolation of two genes that affect mitotic chromosome transmission in S. cerevisiae. Cell 44: 53-63.

  54. Meeks-Wagner, D. and Hartwell, L. H. 1986. Normal stoichiometry of histone dimer sets is necessary for the high fidelity of mitotic chromosome transmission. Cell 44: 43-52.

  55. Jenness, D. D., Burkholder, A. C. and Hartwell, L. H. 1986. Binding of -factor pheromone to Saccharomyces cerevisiae a cells: Dissociation constant and number of binding sites. Mol. Cell. Biol. 6: 318-320.

  56. Burkholder, A. C. and Hartwell, L. H. 1985. The yeast -factor receptor: Structural properties deduced from the sequence of the STE2 gene. Nucl. Acids Res. 13: 8463-8475.

  57. Carson, M. J. and Hartwell, L. 1985. CDC17: An essential gene that prevents telomere elongation in yeast. Cell 42: 249-257.

  58. Hartwell, L. and Smith, D. 1985. Altered fidelity of mitotic chromosome transmission in cell cycle mutants of S. cerevisiae. Genetics 110: 381-395.

  59. Koshland, D., Kent, J. C. and Hartwell, L. 1985. Genetic analysis of mitotic transmission of minichromosomes. Cell 40: 393-403.

  60. *Moore, Susan A. 1984. Yeast cells recover from mating pheromone -factor-induced division arrest by desensitization in the absence of  factor destruction. J. Biol. Chem. 259: 1004-1010.

  61. *Moore, Susan A. 1984. Synchronous cell growth occurs upon synchronizing the two regulatory steps of the Saccharomyces cerevisiae cell cycle. Exp. Cell Res. 151: 542-556.

  62. *Moore, Susan A. 1983. Comparison of dose-response curves for -factor-induced cell division arrest, agglutination, and projection. J. Biol. Chem. 258: 13849-13856.

  63. Jenness, D. D., Burkholder, A. and Hartwell, L. 1983. Binding of -factor pheromone to yeast a cell: Chemical and genetic evidence for an -factor receptor. Cell 35: 521-529.

  64. Dutcher, S. K. and Hartwell, L. H. 1983. Genes that act before conjugation to prepare the S. cerevisiae nucleus for karyogamy. Cell 33: 203-210.

  65. Dutcher, S.K. and Hartwell, L. H. 1983. A test for temporal or spatial restrictions in gene product function during the cell division cycle. Mol. Cell. Biol. 3: 1255-1265.

  66. Hartwell, L. H., Dutcher, S. K., Wood, J. S. and Garvik, B. 1982. The fidelity of mitotic chromosome reproduction in S. cerevisiae. Rec. Adv. Yeast Mol. Biol. 1: 28-38.

  67. *Shuster, J. R. 1982. Start mutants of Saccharomyces cerevisiae are suppressed in carbon catabolite derepressing medium. J. Bacteriol. 151: 1059-1061.

  68. *Shuster, J. R. 1982. Mating defective STE mutations are suppressed by cell division cycle start mutations in Saccharomyces cerevisiae. Mol. Cell Biol. 2: 1052-1063.

  69. *Wood, J. S. 1982. Genetic effects of methyl benzimidazole-2-yl-carbamate on Saccharomyces cerevisiae. Mol. Cell Biol. 2: 1064-1079.

  70. *Wood, J. S. 1982. Mitotic chromosome loss induced by methyl-benzimidazole-2-yl-carbamate as a rapid mapping method in Saccharomyces cerevisiae. Mol. Cell Biol. 2: 1080-1087.

  71. *Dutcher, S. K. 1982. Two cell division cycle mutants of Saccharomyces cerevisiae are defective in transmission of mitochondria to zygotes. Genetics 102:9-17.

  72. *Holm, C. 1982. Clonal lethality caused by the yeast plasmid 2m DNA. Cell 29: 585-594.

  73. *Holm, C. 1982. Sensitivity to the yeast plasmid 2m DNA is conferred by the nuclear allele nib. Mol. Cell Biol. 2: 985- 992.

  74. Wood, J. S. and Hartwell, L. H. 1982. A dependent pathway of gene functions leading to chromosome segregation in S. cerevisiae. J. Cell Biol. 94: 718-726.

  75. Dutcher, S. K. and Hartwell, L. H. 1982. The role of cell division cycle genes in nuclear fusion in Saccharomyces cerevisiae. Genetics 100: 175-184.

  76. *Dutcher, S. K. 198 1. Internuclear transfer of genetic information in karl-1/KAR1 heterokaryons in Saccharomyces cerevisiae. Mol. Cell. Biol. 1: 245-253.

  77. Pringle, J. R. and Hartwell, L. H. 1981. The Saccharomyces cerevisiae cell cycle. In: Molecular biology of the yeast Saccharomyces. I. Ed. J. N. Strathern, E. W. Jones, and J. R. Broach. Cold Spring Harbor Laboratory, pp. 97- 142..

  78. *Nasmyth, K. A. and Reed, S. I. 1980. Isolation of genes by complementation in yeast: Molecular cloning of a cell-cycle gene. Proc. Natl. Acad. Sci. 77: 2119-2123.

  79. *Reed, S. 1980b. The selection of amber mutation in genes required for completion of start, the controlling event of the cell division cycle of S. cerevisiae. Genetics 95: 579-588.

  80. *Reed, S. 1980a. The selection of S. cerevisiae mutants defective in the start event of cell division. Genetics 95: 561- 577.

  81. Hartwell, L. H. 1980. Mutants of Saccharomyces cerevisiae unresponsive to cell division control by polypeptide mating hormone. J. Cell Biol. 85: 811-822.

  82. Hartwell, L. H. 1978. Cell division from a genetic perspective. J. Cell Biol. 77: 627- 637

  83. *Unger, M. W. 1977. Methionyl-transfer RNA deficiency during GI arrest of Saccharomyces cerevisiae. J. Bacteriol.130:11-19.

  84. *Livingston, D. M. and Kupfer, D. 1977. Control of Saccharomyces cerevisiae 2 mm DNA replication by cell division cycle genes that control nuclear DNA replication. J. Mol. Biol. 116: 249-260.

  85. *Livingston, D. M. 1977. Inheritance of the 2 mm DNA plasmid from Saccharomyces. Genetics 86: 73-84.

  86. *Chan, R. K. 1977. Recovery of Saccharomyces cerevisiae mating-type  cells from GI Arrest by  Factor. J. Bacteriol. 130: 766-774.

  87. Hartwell, L. H. and Unger, M. W. 1977. Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division. J. Cell Biol. 75: 422-435.

  88. Reid, Brian J. and Hartwell, L. H. 1977. Regulation of mating in the cell cycle of Saccharomyces cerevisiae. J. Cell Biol. 75: 355-365.

  89. Johnston, G. C., Pringle, J. R. and Hartwell, L. H. 1977. Coordination of growth with cell division in the yeast Saccharomyces cerevisiae. Exp. Cell Res. 105: 79-98.

  90. Hartwell, L. H. 1976. Sequential function of gene products relative to DNA synthesis in the yeast cell cycle. J. Mol. Biol. 104: 803-817.

  91. Unger, M. W. and Hartwell, L. H. 1976. Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA. Proc. Nat. Acad. Sci. 73: 1664-1668.

  92. *Wilkinson, L. E. and Pringle, J. R. 1974. Transient GI arrest of S. cerevisiae cells of mating type a by a factor produced by cells of mating type . Exp. Cell Res. 89: 175-187.

  93. Hartwell, L. H. 1974. Saccharomyces cerevisiae cell cycle. Bact. Rev. 38: 164-198.

  94. Hereford, L. M. and Hartwell, L. H. 1974. Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis. J. Mol. Biol. 84: 445-461.

  95. Hartwell, L. H., Culotti, J., Pringle, J. R. and Reid, B. J. 1974. Genetic control of the cell division cycle in yeast. Science 183: 46-51.

  96. Hereford, L. M. and Hartwell, L. H. 1973. Role of protein synthesis in the replication of yeast DNA. Nature New Biol. 244: 129-131.

  97. Shulman, R. W., Hartwell, L. H. and Warner, J. R. 1973. Synthesis of ribosomal proteins during the yeast cell cycle. J. Mol. Biol. 73: 513-525.

  98. Hartwell, L. H. 1973. Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae. J. Bact. 115: 966-974.

  99. Hartwell, L. H., Mortimer, R. K., Culotti, J. and Culotti, M. 1973. Genetic control of the cell division cycle in yeast: V. Genetic analysis of cdc mutants. Genetics 74: 267-286.

  100. Hartwell, L. H. 1973. Synchronization of haploid yeast cell cycles, a prelude to conjugation. Exp. Cell Res. 76: 111- 117.

  101. Bucking-Throm, E., Duntze, W., Hartwell, L. H. and Manney, T. R. 1973. Reversible arrest of haploid yeast cells at the initiation of DNA synthesis by a diffusible sex factor. Exp. Cell Res. 76: 99-110.

  102. Hereford, Lynna M. and Hartwell, Leland H. 1971. Defective DNA synthesis in permeabilized yeast mutants. Nature New Biol. 234: 171-172.

  103. Hartwell, L. H. 1971. Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp. Cell Res. 69: 265-276.

  104. Culotti, J. and Hartwell, L. H. 1971. Genetic control of the cell division cycle in yeast. III. Seven genes controlling nuclear division. Exp. Cell Res. 67: 389-401.

  105. Hartwell, L. H. 1971. Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation. J. Mol. Biol. 59: 183-194.

  106. Hartwell, L. H. 1970. Periodic density fluctuation during the yeast cell cycle and the selection of synchronous cultures. J. Bact. 104: 1280-1285.

  107. Hartwell, L. H., McLaughlin, C. S. and Warner, J. R. 1970. Identification of ten genes that control ribosome formation in yeast. Mol. Gen. Genetics 109: 42-56.

  108. Hartwell, L. H. 1970. Biochemical genetics of yeast. Ann. Rev. Gen. 4: 373-396.

  109. Hartwell, L., Culotti, J. and Reid, B. 1970. Genetic control of the cell-division cycle in yeast, I. Detection of mutants. Proc. Nat. Acad. Sci. 66: 352-359.

  110. Hartwell, L. H., Hutchison, H. Terry, H., Trudy M. and McLaughlin C. S. 1970. The effect of cycloheximide upon polyribosome stability in two yeast mutants defective respectively in the initiation of polypeptide chains and in messenger RNA synthesis. Mol. Gen. Genetics 106: 347-361.

  111. Martin, T. E. and Hartwell, L. H. 1970. Resistance of active yeast ribosomes to dissociation by KC1. J. Biol. Chem. 245: 1504-1508.

  112. McLaughlin, C. S., Magee, P. T. and Hartwell, L. H. 1969. Role of isoleucyltransfer ribonucleic acid synthetase in ribonucleic acid synthesis and enzyme repression in yeast. J. Bact. 100: 579-584.

  113. Hutchison, H. T., Hartwell, L. H. and McLaughlin, C. S. 1969. Temperature sensitive yeast mutant defective in ribonucleic acid production. J. Bact. 99: 807-814.

  114. McLaughlin, C. S. and Hartwell, L. H. 1969. A mutant of yeast with a defective methionyl-tRNA synthetase. Genetics 61: 557-566.

  115. Hartwell, L. H. and McLaughlin, C. S. 1969. A mutant of yeast apparently defective in the initiation of protein synthesis. Proc. Nat. Acad. Sci. 62:468-474.

  116. Hartwell, L. H. and McLaughlin, C. S. 1968. Temperature-sensitive mutants of yeast exhibiting a rapid inhibition of protein synthesis. J. Bact. 96: 1664-1671.

  117. Hartwell, L. H. and McLaughlin, C. S. 1968. Mutants of yeast with temperature- sensitive isoleucyl-tRNA synthetases. Proc. Nat. Acad. Sci. 59: 422-428.

  118. Hutchison, H. T. and Hartwell, L. H. 1967. Macromolecule synthesis in yeast spheroplasts. J. Bact. 94: 1697-1705.

  119. Hartwell, L. H. 1967. Macromolecule synthesis in temperature-sensitive mutants of yeast. J. Bact. 93: 1662-1670.

  120. Hartwell, L. H., Vogt, M. and Dulbecco, R. 1965. Induction of cellular DNA synthesis by polyoma virus II. Increase in the rate of enzyme synthesis after infection with polyoma virus in mouse kidney cells. Virology 27: 262-272.

  121. Dulbecco, R., Hartwell, L. H. and Vogt, M. 1965. Induction of cellular DNA synthesis by polyoma virus. Proc. Natl. Acad. Sci. 53: 403-410.

  122. Hartwell, L. H. and Magasanik, B. 1964. The mechanism of histidase induction and formation in Bacillus subtilis. J. Mol. Biol. 10: 105-119.

  123. Hartwell, L. H. and Magasanik, B. 1963. The molecular basis of histidase induction in Bacillus subtilis. J. Mol. Biol. 7: 401-420.

  124. Hartwell, L H. 1961. An upper limit to the map distance separating the two cistrons of the rII region of bacteriophage T4B. Virology 15: 510-511.

* Work done in Hartwell lab and supported by grants awarded to L. Hartwell.