Publications

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2017

  1. Incorporation of Phosphorylated Tyrosine into Proteins: In Vitro Translation and Study of Phosphorylated IκB-α and Its Interaction with NF-κB. Chen S, Maini R, Bai X, Nangreave RC, Dedkova LM, Hecht SM. J Am Chem Soc. 2017 Oct 11;139(40):14098-14108. doi: 10.1021/jacs.7b05168. Epub 2017 Sep 27. PMID: 28898075
  2. Bai X, Talukder P, Daskalova SM, Roy B, Chen S, Li Z, Dedkova LM, Hecht SM. Enhanced Binding Affinity for an i-Motif DNA Substrate Exhibited by a Protein Containing Nucleobase Amino Acids. J Am Chem Soc. 2017 Apr 5;139(13):4611-4614. doi: 10.1021/jacs.6b11825. Epub 2017 Mar 17. PubMed PMID: 28263595.
  3. Daskalova SM, Bhattacharya C, Dedkova LM, Hecht SM. Probing the Flexibility of the Catalytic Nucleophile in the Lyase Catalytic Pocket of Human DNA Polymerase β with Unnatural Lysine Analogues. Biochemistry. 2017 Jan 24;56(3):500-513. doi: 10.1021/acs.biochem.6b00807. Epub 2017 Jan 12. PubMed PMID: 28005340.

2016

  1. Talukder, P; Dedkova, L. M.; Ellington, A.D.; Yakovchuk, P.; Lim, J.; Anslyn, E.V.; Hecht, Sidney M. (2016) “Synthesis of alanyl nucleobase amino acids and their incorporation into proteins” Bioorganic & Medicinal Chemistry, 24(18) 4177-4187.

  2. Chowdhury, S. R., Chauhan, P, Dedkova, L.M., Bai, X., Chen, S., Taluketer, P., and Hecht, S.M. (2016) “Synthesis and Evaluation of a library of fluorescent dipeptidomimetic analogues as substrates for modified bacteria ribosome” Biochemistry, 55(17), 2427-2440.


2015

  1. Chowdhury, S. R., Maini, R., Dedkova, L.M., and Hecht, S.M. (2015) “Synthesis of fluorescent dipeptidomimetics and their ribosomal incorporation into green fluorescent protein” Bioorg. Med. Letters, 25(21), 4715-4718.

  2. Gerasimova, Y.V., Yakovchuk, P., Dedkova, L.M., Hecht, S.M., and Kolpashchikov, D.M. (2015) “Expedited quantification of mutant ribosomal RNA by binary deoxyribozyme (BiDz) sensor” RNA, 21(10), 1834-1843.

  3. Maini, R., Dedkova, L.M., Paul, R., Madathil, M.M., Chowdhury, S.R., Chen, S., and Hecht, S.M. (2015) Ribosome-Mediated Incorporation of Dipeptides and Dipeptide Analogues into Proteins in Vitro” J. Am. Chem. Soc., 137, 11206-11209.

  4. Maini,R., Chowdhury, S.R. Dedkova, L.M.,  Roy, B., Daskalova, S., Paul, R., Chen, S. and Hecht, S.M. (2015) “Protein Synthesis with Ribosomes Selected for the Incorporation of β-Amino Acids” Biochemistry, 54, 3694-3706.


2014

  1. Yu, X., Talukder, P., Bhattacharya, Ch, Fahmi, N., Lines, J.A., Dedkova, L.M., Labaer, J., Hecht, S.M., and Chen, S. (2014) “Probing of CD4 binding pocket of HIV-1 gp 120 glycoprotein using unnatural phenylalanine analogue” Bioorg. Med. Letters, 24(24), 5699-5703.

  2. Lines, J.A., Yu, Z., Dedkova, L.M., and Chen, S. (2014). “Design and expression of a short peptide as an HIV detection probe” BBRC, 443, 308-312.


2013

Maini, R., Nguyen, D., Chen, S., Dedkova, L.M., Roy Chowdhury, S., Alcala-Torano, R., and Hecht, S.M. (2013) “Incorporation of β-amino acids into dihydrofolate reductase by ribosomes having modification in the peotidyltransferase center” Bioorganic & Medicinal Chemistry, 21(5), 1088-1096.


2012

Dedkova L.M., Fahmi, N., Paul, R., delRossario, M., Zhang, L., Chen, S., Feder, G. and Hecht, S.M. (2012) “β-puromycin selection of modified ribosomes for in vitro incorporation of β-amino acids” Biochemistry, 51, 401-415.


2011

Nangreave, R.C., Dedkova, L.M., Chen, S., and Hecht, S.M. (2011) “A new strategy for the synthesis of bisaminoacylated tRNAs” Org. Letters, 13(18), 4906-4909.


2009

Hecht, S., Fahmi, N., Dedkova, L., Bera, S., Kolanos, R. (2009) “Cyclodextrin derivatives as potentiator for antibiotics”. WO/2009/058327


2008

Gao, Z., Maloney, D.J; Dedkova L.M., and Hecht, S.M. (2008) Inhibitors of DNA polymerase beta: activity and mechanism. Bioorganic & Medicinal Chemistry, 16(8), 4331-4340.


2007

  1. Hecht, S., Deng, J.-Z., Dedkova, L. (2007) Antibacterial compounds and uses thereof. WO/2007/086895

  2. Fahmi, N.E, Dedkova L., Wang, B., Golovine, S., and Hecht, S.M. (2007) Site-specific incorporation of glycosylated serine and tyrosine derivatives into proteins. J. Am. Chem. Soc., 129(12), 3586-3597.

  3. Choudhury, A.K., Golovine, S.Y, Dedkova, L., Laikhter A.L., and Hecht, S.M. (2007) Synthesis of proteins containing modified arginine residues. Biochemistry, 46(13), 4066-4076.


2006

  1. Dedkova, L.M., Fahmi, N.E., Golovin, S.Y. and Hecht, S.M. (2006) Construction of modified ribosomes for incorporation of D-amino acids into proteins. Biochemistry, 45(51), 15541-15551.

  2. Schmidt, F.J., Dedkova, L. and Hecht, S. (2006) Parallel Identification of antibacterial targets and inhibitors. WO/2006/086696

  3. Hecht, S., Deng, J.-Z., and Dedkova, L. (2006) Preparation of polybromodiphenyl ethers as a antibacterial agents. WO/2006/235047

  4. Gao,R., Zhang, Y., Dedkova, L, Choundhury, A.K., Rahier, N.J. and Hecht, S.M. (2006) Effects of modification of the active site tyrosine of human DNA Topoisomerase I. Biochemistry 45(27), 8402-8410.


2005

Gao R., Zhang Y., Choudhury, A.K., Dedkova, L.M., and Hecht, S.M. (2005) Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine. J.Am.Chem.Soc. 127, 3321-3331.


2004

Golovine, S.Y, Hecht, S.M., Dedkova, L.M. (2004) Methods of protein synthesis incorporating D-amino acids using  modified ribosome.  PCT Int. Appl. WO/ 2004/035757


2003

  1. Dedkova, L.M., Fahmi N.E., Golovine, S.Y., and Hecht S.M. (2003). Enhanced D-amino acid incorporation into protein by modified ribosomes. J.Am.Chem.Soc. 125, 6616-6617

  2. Poryvayeva, V.A., Aborneva, I. V., Bormotov, N.I., Gladkova, S.E., Reshetnikov, S.S., Kuvshinova, I.N., Rukavishnikov, M. Yu., Dedkova, L.M., Belanov, E.F. (2003) Production and characterization of a panel of monoclonal antibodies to Toxoplasma gondii antigens   Molekulyarnaya Genetika, Mikrobiologiya i Virusologiya, N 4, 20-24 (Russ.)


2002

Zubavichene N.M., Dedkova L.M., Sergeev N.N., Ofitserov V.I. (2002) Sensitizing and virus-neutralizing characteristics of goat immunoglobulins against Ebola virus. Voprosy Virusologii, V.47, N 2, P. 45-48. (Russ.).


2000

  1. Poryvaeva V.A., Aborneva I.V., Dedkova L.M., Rukavishnikov M.Yu., Bormotov N.I., Belanov E.F. (2000) Immunocemical characterization of the collection of monoclonal antibodies to the Toxoplasma gondii antigens. Acta Parasitologica, V.45, N.3. P.199-200.

  2. Belanov E.F., Tkachenko T.N., Gladkova S.E., Poryvaeva V.A., Aborneva I.V., Dedkova L.M. (2000) Determination of circulating antigens of Toxoplasma gondii in blood sera. Acta Parasitologica, V.45, N.3, P.205.

  3. Gladkova S. Ye, Bormotov N.I., Dedkova L.M., Belanov E.F., Golubiatnikova A.V, Kiseleva Z.F., Reshetnikov S.S. (2000) Examining the composition of circulating immune complexes in acute toxoplasmosis. Med. Parazitologiya  N 4,  15-18 (Russ.)

  4. Dedkova L.M., Bormotov N.I., Gladkova S.Ye., Belanov Ye.F. (2000) Investigation of protein composition and  immunochemical properties of excreted/secreted antigens of Toxoplasma gondii. Med. Parazitologiya, N1, pp.20-24 (Russ.).


Before 2000

  1. Dedkova L.M., Volkov G.N., Serova O.A., Belanov Ye.F (1999) Immunoassay of antibodies to the antigens of Lamblia trophozoites.  Med. parazitologiya, N.1, P.46-48. (Russ.)

  2. Gladkova S.Ye., Bormotov N.I., Dedkova L.M., Reshetnikov S.S., Belanov Ye.F. (I998)  An immunochemical study of the antigens from Toxoplasma gondii tachyzoites obtained in different cultivation systems.  Med. parazitologiya, N.I, P.20-23. (Russ.)

  3. Chepurnov A.A., Kudoyarova N.M., Dedkova L.M., Sergeyev N.N., Netesov S.V. (I998) Developing methods of specific heterologic immunoglobulins preparation for urgent prevention of Ebola fever and study of their properties. Vestnik Rossiiskoi akademii  nayk, N 4, P.24-29. (Russ.)

  4. Frolova S.B., Volkov G.N., Bormotov N.I., Dedkova L.M., Belanov Ye.F. (1997) The seroepidemiology of toxocariasis in an opisthorchiasis focus in the western Siberian region.  N 4, P.21-24. (Russ.)

  5. Jurkina E.A., Ofitserov V.I., Samukov V.V., Dedkova L.M., Mizenko G.A.(1997) Immunoenzyme method of the determination of human chorionic gonadotropin using polyclonal antibodies.  Klinicheskaya u laboratornaya diagnostika, NI, P.8-10. (Russ).

  6. Kudojarova N.M., Kizimov N.V., Dedkova L.M., Smolina M.P. and Sergeev N.N. (1997) Method of preparation of geterological immunoglobulins against Ebola and Marburg virus infection. RU2089217

  7. Dedkova L.M., Kudoyarova N.M., Chepurnov A.A., Ofitserov. V.I. (1994) Composition and immunochemical characteristics of goat immunoglobulins to Ebola virus. Voprosy Virusologii, V.39 (5), P.229-232. (Russ.)

  8. Ofitserov V.I., Yastrebov S.I., Nikolaeva E.N., Dedkova L.M., Pokrovsky A.G. (1994) Composite sorbents for affinity chromatography of proteins. Bioorganic Chemistry, V.20, N10, P.1089-1094. (Russ.)

  9. Kipriyanov S.M., Ofitserov. V.I, Dedkova L.M., Serpinskij, O.I. (1994) Recombinant Plasmid DNA PUE41 encoding envelope protein fragments GP120 and GP41 of Human Immunodeficiancy virus type 1.” SU 1766070.

  10. Dedkova L.M., Kudoyarova N.M., Shaprov V.N., Sabirov A.N., Ofitserov V.I. (1993) Subclasses of immunoglobulin G from normal and hyperimmune sera of goat. Izvestiya Sibirskogo otdeleniya Akademii Nauk, N 6, P.8-13. (Russ.).

  11. Dedkova L.M., Yastrebov S.I., Ofitserov V.I. (1992) Activity of IgG subclasses, produced from hyperimmune sera against TBE virus. Izvestiya Sibirskogo otdeleniya Akademii Nauk, N3, P.21-24. (Russ.).