Publications

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2020

Jacqueline Leung*, Eiji Nagayasu*, Yu-Chen Hwang, Phil Pierce, Isabelle Phan, Robin Stacy, John M. Murray, Ke Hu. “A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers”  BMC Molecular and Cell Biology. 21(1):8.  doi: 10.1186/s12860-020-0249-5


2019

  1. Jacqueline Leung*, Jun Liu*, Laura Wetzel, John M. Murray, Ke Hu. "Centrin2 from the human parasite Toxoplasma gondii is required for its invasion and intracellular replication" Journal of Cell Science 132: jcs228791 (* Equal Contribution)

  2. Jacqueline Leung*, Eiji Nagayasu*, Yu-Chen Hwang, Phil Pierce, Isabelle Phan, Robin Stacy, John M. Murray, Ke Hu. “A doublecortin-domain protein of Toxoplasma and its orthologues bind to and modify the structure and organization of tubulin polymers” bioRxiv doi: https://doi.org/10.1101/623140 (* Equal Contribution)


2018

Yulia Pivovarova, Jun Liu, Johannes Lesigang, Oliver Koldyka, Rene Rauschmeier, Ke Hu* and Gang Dong*. "Structure of a novel dimeric set domain methyltransferase that regulates cell motility" Journal of Molecular Biology, S0022-2836(18)30422-4. (* Equal Contribution)


2017

  1. Jacqueline M. Leung, Yudou He, Fangliang Zhang, Yu-Chen Hwang, Eiji Nagayasu, Jun Liu, John M. Murray, Ke Hu "Stability and function of a putative microtubule organizing center in the human parasite Toxoplasma gondii"  Molecular Biology of the Cell E17-01-0045 (Featured on Cover of Journal) 

  2. Rachel Stadler, Lauren White, Ke Hu, Brian Helmke, William Guilford "Direct measurement of cortical force generation and polarization in a living parasite" Molecular Biology of the Cell, doi: 10.1091/mbc.E16-07-0518 (Selected for the special issue “Forces On and Within Cells”)


2016

Nagayasu, E., Y.-c. Hwang, J. Liu, J. Murray, and K. Hu, "Loss of a doublecortin (DCX) domain containing protein causes structural defects in a tubulin-based organelle of Toxoplasma gondii and impairs host cell invasion." Molecular Biology of the Cell. 10.1091/mbc.E16-08-0587


2015

J. Liu*, Y. He*, I. Benmerzouga, W. J. Sullivan Jr., N. S. Morrissette, J. M. Murray, K. Hu. “An ensemble of specifically targeted proteins stabilizes cortical microtubules in the human parasite Toxoplasma gondii” Molecular Biology of the Cell E15-11-0754. PMID:26680740 (Featured on cover of journal)(* Equal contributions)


2013

  1. Senthilkumar Sivagurunathan, Aoife Heaslip, Jun Liu, Ke Hu. 2013. "Identification of functional modules of AKMT, a novel lysine methyltransferase regulating the motility of Toxoplasma gondii" Molecular & Biochemical Parasitology 189: 43–53.

  2. Jun Liu, Laura Wetzel, Ying Zhang, Eiji Nagayasu, Stephanie Ems-McClung, Laurence Florens, Ke Hu. "Novel thioredoxin-like proteins are components of a protein complex coating the cortical microtubules of Toxoplasma gondii" Eukaryotic Cell 12(12):1588-99 (Featured on cover of journal)


2011

A.T. Heaslip, M. Nishi, B. Stein, K. Hu . "The motility of a human protozoan parasite, Toxoplasma gondii, is regulated by a novel lysine methyltransferase" PLoS Pathogens 7(9): e1002201 (Faculty of 1000 Selection)


2010

A.T. Heaslip, F. Dzierszinski, B. Stein, K. Hu. "TgMORN1 is a key organizer of the basal complex in Toxoplasma gondii" PLoS Pathogens 6(2):e1000754


2009

A. T. Heaslip, S. C. Ems-McClung, K. Hu 2009. "TgICMAP1 is a novel microtubule binding protein in Toxoplasma gondii" PLoS One 4(10): e7406. doi:10.1371/journal.pone.0007406


2008

  1. Natalia de Miguel, Maryse Lebrun, Aoife Heaslip, Ke Hu, Con J. Beckers, Mariana Matrajt, Jean François Dubremetz and Sergio O. Angel. "Toxoplasma gondii Hsp20 is a stripe-arranged chaperone localized in the outer leaflet of the inner membrane complex" Biology of the Cell 100(8):479-89

  2. Hu K 2008. "Organizational changes of the daughter basal complex during the parasite replication of Toxoplasma gondii" PLoS Pathogens 4(1): e10 doi:10.1371/journal.ppat.0040010

  3. Manami Nishi, Ke Hu, John M. Murray, and David S. Roos. "How to Build a Parasite: Organellar Dynamics during the Cell Cycle of Toxoplasma gondii" Journal of Cell Science 121:1559-1568


2007

Hu, K*., Ji L*., Applegate, K.T., Danuser G., Waterman-Storer C. "Differential Transmission of Actin Motion Within Focal Adhesions" Science 315:111-115. (Featured in "Editor's Choice" in Science: S. M. Hurtley, Cellular Mechanics Up Close and Personal. Sci. STKE 2007, tw15 (2007))(Faculty of 1000 Selection)(* Equal Contribution)


2006

  1. K. Hu, J. Johnson, L. Florens, M. Fraunholz, S. Suravajjala, C. DiLullo, J. Yates, D. S. Roos and J. M. Murray."Cytoskeletal components of an invasion machine – the apical complex of Toxoplasma gondii" (cover) PloS Pathogens, 2(2): 0121-0138 (Faculty of 1000 Selection)

  2. Stacey D. Gilk, Yossef Raviv, Ke Hu, John Murray, Con J.M. Beckers, and Gary E. Ward. "Identification of PhIL1, a Novel Cytoskeletal Protein of the Toxoplasma gondii Pellicle, through Photosensitized Labeling with 5-[125I]Iodonaphthalene-1-Azide" Eukaryotic Cell 5: 1611-1621


2004

K. Hu, D. S. Roos, S. O. Angel and J. M. Murray. "Variability and heritability of cell division pathways in T. gondii" Journal of Cell Science 2004 117: 5697-5705


2003

D. M. Wetzel, S. Hakansson, K. Hu, D. Roos, and L. D. Sibley. "Actin Filament Polymerization Propels Gliding Motility by Apicomplexan Parasites" Molec. Biol. Cell 14: 396-406


2002

  1. Hu, K., T. Mann, B. Striepen, C.J. M. Beckers, D. S. Roos and J. M. Murray. "Daughter cell assembly in the protozoan parasite Toxoplasma gondii" Molec. Biol. Cell 13: 593-606.

  2. Pelletier, L., Stern, A., Pypaert, M., Sheff, D., Ngo, H., Roper, N., He, C., Hu, K., Toomre, D., Coppens, I., Roos, D., Joiner, K and Warren, G. "Golgi Biogenesis in Toxoplasma gondii" Nature 418, 548-552.

  3. Swedlow, J.R., K. Hu, P.D. Andrews, D. S. Roos and J. M. Murray. "Measurement of tubulin content in the conoid and spindle pole of the parasite Toxoplasma gondii: A comparison of laser scanning confocal and wide field fluorescence microscopy for quantitative analysis in living cells" Proc. Nat'l Acad. Sci. USA 99:2014-2019.

  4. Hu, K., D. S. Roos and J. M. Murray. "A novel polymer of tubulin forms the conoid in Toxoplasma gondii"(cover) J. Cell Biol. 156:1039-1050.