Publications

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2019

  1. Song, J., D. Logeswaran, C. Castillo-González, Y. Li, S. Bose, B. Aklilu, Z. Ma, A. Polkhovskiy, J.J.-L. Chen* and D.E. Shippen* (2019). The conserved structure of plant telomerase RNA provides the missing link for an evolutionary pathway from ciliates to humans. Proc. Natl. Acad. Sci. U.S.A. 116(49): doi.org/10.1073/pnas.1915312116 (*co-corresponding) 

  2. Logeswaran, D. and J.J.-L. Chen (2019) Effects of Telomerase Activation. In Encyclopedia of Gerontology and Population Aging, Vol. 1, D. Gu and M. Dupre, eds. Springer Press. doi:10.1007/978-3-319-69892-2_42-1. 


2018

Chen, Y., J.D. Podlevsky, D. Logeswaran and J.J.-L. Chen (2018). A single nucleotide incorporation step limits human telomerase repeat addition activity. EMBO J. 37:e97953, DOI 10.15252/emboj.201797953.


2017

Donaires, F.S., N.F. Scatena, R.M. Alves-Paiva, J.D. Podlevsky, B.A. Santana, A.C. Teixeira, J.J.-L. Chen, R.T. Calado and A.L.C. Martinelli (2017). Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma. PLoS ONE 12(8): e0183287.


2016

  1. Podlevsky, J.D., Y. Li and J.J.-L. Chen (2016) The functional requirement of two structural domains within telomerase RNA emerged early in eukaryotes. Nucleic Acids Research  44(20): 9891-9901. 

  2. Podlevsky, J.D. and J.J.-L. Chen (2016) Evolutionary perspectives of telomerase RNA structure and function. RNA Biology 13(8): 720-732. 

  3. Podlevsky, J.D., Y. Li and J.J.-L. Chen (2016) Structure and function of echinoderm telomerase RNA. RNA 22(2): 204-215.


2015

  1. J.J.-L. Chen and, J.D. Podlevsky (2015) Telomeres and telomerase. In Encyclopedia of Cell Biology, Vol. 1, R. Bradshaw and P. Stahl, eds. Waltham, MA: Academic Press, p. 418-425. 

  2. Qi, X., D.R. Rand, J.D. Podlevsky, Y. Li, A. Mosig, P.F. Stadler and J.J.-L. Chen(2015) Prevalent and distinct spliceosomal 3'-end processing mechanisms for fungal telomerase RNA. Nature Communications 6, 6105. 

  3. Stanley, S.E., J.J.-L. Chen, J.D. Podlevsky, J.K. Alder, N.N. Hansel, R. Mathias, X. Qi, N.N. Rafaels, R.A. Wise, E.K. Silverman, K.C. Barnes and M. Armanios (2015) Telomerase mutations in smokers with emphysema. The Journal of Clinical Investigation 125(2), 563-70.


2014

  1. Brown, A.F., J.D. Podlevsky, X. Qi, Y. Chen, M. Xie, and J.J.-L. Chen (2014) A self-regulating template in human telomerase. Proc. Natl. Acad. Sci. U.S.A. 111(31): 11311-11316. [From the Cover: Commentary] 

  2. Huang, J., A.F. Brown, J. Wu, J. Xue, C.J. Bley, D.P. Rand, L. Wu, R. Zhang, J.J.-L. Chen* and M. Lei* (2014) Structural basis for protein-RNA recognition in telomerase. Nature Structural and Molecular Biology 21:507-512. (*co-corresponding)

  3. Brown, A.F., J.D. Podlevsky and J.J.-L. Chen (2014) Telomerase: A eukaryotic DNA polymerase specialized in telomeric repeat synthesis. In Nucleic Acid Polymerases-1st edition, M. Trakselis and K. Murakami, eds., Springer Press. p.215-236.


2013

  1. Li, Y., J.D. Podlevsky, M. Marz, X. Qi, S. Hoffmann, P.F. Stadler and J.J.-L. Chen(2013)   Identification of purple sea urchin telomerase RNA using a next-generation sequencing based approach. RNA 19(6): 852-860

  2. Gramatges, M.M., X. Qi, G.S. Sasa, J.J.-L. Chen and A.A. Bertuch (2013) A homozygous telomerase T motif variant resulting in markedly reduced repeat addition processivity in siblings with Hoyeraal Hreidarsson syndrome. Blood 121(18):3586-3593


2012

  1. Qi, X., Y. Li, S. Honda, S. Hoffmann, M. Marz. A. Mosig, J.D. Podlevsky, P.F. Stadler, E. Selker and J.J.-L. Chen (2012) The common ancestral core of vertebrate and fungal telomerase RNAs. Nucleic Acids Research 41(1): 450-462. 

  2. Qi, X., M. Xie, A.F. Brown, C.J. Bley, J.D. Podlevsky and J.J.-L. Chen (2012) RNA/DNA hybrid binding affinity determines telomerase template translocation efficiency. EMBO J. 31: 150-161.

  3. Tzfati, Y. and J.J.-L. Chen (2012) Telomerase RNA: Structure, function, and molecular mechanisms. In Telomerases: Chemistry, Biology and Clinical Applications-1st edition, N. Lue and C. Autexier, eds., John Wiley & Sons, Inc. p.23-51.

  4. Podlevsky, J.D. and J.J.-L. Chen (2012) It all comes together at the ends: Structure, function, and biogenesis of telomerase. Mutation Research 730: 3-11.


2011

  1. Bley, C.J., X. Qi, D.P. Rand, C.R. Borges, R.W. Nelson and J.J.-L. Chen (2011) RNA-protein binding interface in the telomerase ribonucleoprotein. Proc. Natl. Acad. Sci. U.S.A. 108(51): 20333-20338. 

  2. Parry, E.M., J.K. Alder, X. Qi, J.J.-L. Chen and M.Y. Armanios (2011) Syndrome complex of bone marrow failure and pulmonary fibrosis predicts germline defects in telomerase. Blood 117(21): 5607-5611. 

  3. Alder, J.K., J.D. Cogan, A.F. Brown, C.J. Anderson, W.E. Lawson, P.M. Lansdorp, J.A. Phillips 3rd, J.E. Loyd, J.J.-L. Chen, and M.Y. Armanios (2011) Ancestral mutation in telomerase causes defects in repeat addition processivity and manifests as familial pulmonary fibrosis. PLoS Genetics 7(3): e1001352. 

  4. Lawrence, R.M., B. Varco-Merth, C.J. Bley, J.J.-L. Chen, and P. Fromme (2011) Recombinant production and purification of the subunit c of chloroplast ATP synthase. Protein Expression and Purification 76: 15-24.


2010

  1. Xie, M., J.D. Podlevsky, X. Qi, C.J. Bley and J.J.-L. Chen (2010) A novel motif in telomerase reverse transcriptase regulates telomere repeat addition rate and processivity. Nucleic Acids Research 38: 1982-1996. 


2009

Stadler,P.F., J.J.-L. Chen, J. Hackermuller, S. Hoffmann, P. Khaitovich, A. Kretzschmar, A. Mosig, S.J. Prohaska, X. Qi, K. Schutt and K. Ullmann (2009) Evolution of vault RNAs. Molecular Biology and Evolution 26: 1975-1991. 


2008

  1. Alder, J.K., J.J.-L Chen, L. Lancaster, S. Danoff, S.C. Su, M. Prince, I. Vulto, M. Xie, X. Qi, R.M. Tuder, J.A. Phillips, P.M. Lansdorp, J.E. Loyd and M.Y. Armanios (2008) Short telomeres are a risk factor for idiopathic pulmonary fibrosis. Proc. Natl. Acad. Sci. U.S.A. 105: 13051-13056. 

  2. Ye, Y., W. Wen, Y. Xiang, X. Qi, J.T. LaBelle, J.J.-L. Chen and J. Wang (2008) Direct electrochemical monitoring of RNase activity. Electroanalysis 20: 919-922.

  3. Xie, M., A. Mosig, X. Qi, Y. Li, P.F. Stadler and J.J.-L. Chen (2008) Structure and function of the smallest vertebrate telomerase RNA from teleost fish. Journal of Biological Chemistry 283: 2049-2059.

  4. Podlevsky, J.D., C.J. Bley, R.V. Omana, X. Qi and J.J.-L. Chen (2008) The telomerase database. Nucleic Acids Research 36: D339-D343.


2007

  1. Li, Y., J.A. Yates and J.J.-L. Chen (2007) Identification and characterization of sea squirt telomerase reverse transcriptase. Gene 400: 16-24.

  2. Xiang, Y, M. Xie, R. Bash, J.J.-L. Chen and J. Wang (2007) Ultrasensitive label-free aptamer-based electronic detection. Angewandte Chemie Int. Ed. 46(47): 9054-9056.

  3. Mosig, A, J.J.-L. Chen and P.F. Stadler (2007) Proc. Worksh. Alg. Bioinf. (WABI) 2007: Homology search with fragmented nucleic acid sequence patterns. Lect. Notes Comput. Sc. 46(45): 335-345.

  4. Armanios, M., J.J.-L. Chen, W.E. Lawson, J.K. Alder, R.G. Ingersoll, C. Markin, M. Xie, J. Cogan, J.A. Philips III, P.M. Lansdorp, C.W. Greider and J.E. Loyd (2007) Telomerase mutations in families with idiopathic pulmonary fibrosis. New England Journal of Medicine 356: 1317-1326.


2006

  1. Lin, C., M. Xie, J.J.-L Chen, Y. Liu and H. Yan (2006) Rolling-circle amplification of a DNA nanojunction. Angewandte Chemie Int. Ed. 45: 7537-7539.

  2. Marquez, S.M., J.-L Chen, D. Evans and N.R. Pace (2006) Structure and function of eukaryotic ribonuclease P RNA. Molecular Cell 24: 445-456.


2005

  1. Armanios, M., J.J.-L Chen, Y.-P. Chang, R. A. Brodsky, A. Hawkins, C.A. Griffin, J.R. Eshleman, A. Chakravarti, A. Hamosh and C.W. Greider (2005) Haploinsufficiency of hTERT leads to anticipation in autosomal dominant dyskeratosis congenital. Proc. Natl. Acad. Sci. U.S.A. 102: 15960-15964. 

  2. Chen, J.-L. and C.W. Greider (2005) Functional analysis of the pseudoknot structure in human telomerase RNA. Proc. Natl. Acad. Sci. U.S.A. 102: 8080-8085.

  3. Chen, J.-L. and C.W. Greider (2005) Telomerase biochemistry and biogenesis. In Telomeres-2nd edition, T. deLange, E. Blackburn and V. Lundblad, eds., Cold Spring Harbor Laboratory Press. p.49-79.


2004

  1. Chen, J.-L. and C.W. Greider (2004) An emerging consensus for telomerase RNA structure. Proc. Natl. Acad. Sci. U.S.A. 101: 14683-14684.

  2. Chen, J.-L. and C.W. Greider (2004) Telomerase RNA structure and function: implications for dyskeratosis congenita. Trends in Biochemical Sciences 29: 183-192.


2003

  1. Chen, J.-L. and C.W. Greider (2003) Template boundary definition in mammalian telomerase. Genes & Development 17: 2747-2752.

  2. Chen, J.-L. and C.W. Greider (2003) Determinants in mammalian telomerase RNA that mediate enzyme processivity and cross-species incompatibility. EMBO J. 22: 304-314.