Jia Fan

Jia Fan

Assistant Research Professor, Biodesign Virginia G. Piper Center for Personalized Diagnostics

Bio

I have a strong background in biochemistry, molecular biology, analytical chemistry and nanotechnology, starting from my Ph.D. studies, during which I worked on several interdisciplinary projects. My research focuses on developing and validating integrated nanotechnique-based strategies for marker discovery and development of non-invasive clinical diagnostics approaches that use blood or urine samples. My goal is to provide translatable solutions for personalized medicine in early disease diagnosis to improve patient outcomes. My previous works including discovery and quantification of circulating disease-derived exosome markers for early diagnosis, detection of pathogenic antigens for rapid diagnosis of M. tuberculosis, and development of a nanopore-based method for low molecular weight protein/peptide detection that addresses a bottleneck in the measurement of low-abundance peptides in bodily fluids. I intend to further develop or adapt these approaches for use in my future clinical biomarker studies. I have published 20 peer-reviewed papers (7 first-author), filed three patents (one awarded, two provisional), and received awards and recognition from several scientific societies, including the US Human Proteome Organization (US HUPO) and The Association for Mass Spectrometry: Applications to the Clinical Laboratory (MSACL). My studies served as the basis for three RO1, one R21 and two Foundation awards (total $8.5M). Based on my extensive experience with multidisciplinary approaches for leveraging nanotechnology applications in our projects with clinicians, biostatisticians and clinical chemists, I will be a qualified candidate and be able to complete the proposed plan.