Publications

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  1. Snowden R, Harrington H, Morrill K, Jeane L, Garrity J, Orian M, Lopez E, Rezaie S, Hassberger K, Familoni D, Moore J, Virdee K, Albornoz-Sanchez L, Walker M, Cavins J, Russell T, Guse E, Reker M, Tschudy O, Wolf J, True T, Ukaegbu O, Ahaghotu E, Jones A, Polanco S, Rochon Y, Waters R, Langland J. A comparison of the anti-Staphylococcus aureus activity of extracts from commonly used medicinal plants. J Altern Complement Med. 2014 May;20(5):375-82. doi: 10.1089/acm.2013.0036. Epub 2014 Mar 17.

  2. Morrill K, May K, Leek D, Langland N, Jeane LD, Ventura J, Skubisz C, Scherer S, Lopez E, Crocker E, Peters R, Oertle J, Nguyen K, Just S, Orian M, Humphrey M, Payne D, Jacobs B, Waters R, Langland J.Spectrum of antimicrobial activity associated with ionic colloidal silver. J Altern Complement Med. 2013 Mar;19(3):224-31. doi: 10.1089/acm.2011.0681. Epub 2012 Sep 27.

  3. Arndt, W., Mitnik, C., Denzler, K.L., Waters, R.F., Jacobs, B.L., Rochon, Y., and Langland, J.O. (2010). Rediscovery of a 19th century cure for smallpox. Nature (manuscript in preparation).

  4. Willis, K.L., Langland, J.O., and Shisler, J.L. (2010). Viral dsRNA from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-KB activation, when the K1 protein is absent or mutated. (submitted).

  5. Waters, R.F., Langland, J.O., Woffinden, S., Worsham, A., Leek, D., Orian, M., Gelinas, B., Reziae, S., and Russell, T., (2010). A Mathematical Comparison of Multiple Linear Regression Analysis with Inductive Rule Extraction in the Analysis of Data in Alternative Medicine (submitted).

  6. White, S.D., Conwell, K., Langland, J.O. and Jacobs, B.L. (2010). Use of a Negative Selectable Marker for Rapid Selection of Recombinant Vaccinia Virus. Biotechniques (submitted).

  7. Denzler, K.L., Waters, R.F., Jacobs, B.L., Rochon, Y., and Langland, J.O. (2010). Regulation of inflammatory gene expression by immunostimulatory botanicals. PLoS ONE (in press).

  8. Morrill, K., May, K., Leek, D., Langland, N., Jeane, L., Ventura, J., Skubisz, C., Scherer, S., Lopez, E., Crocker, E., Peters, R., Oertle, J., Nguyen, K., Just, S., Phair, M., Humphrey, M., Payne, D., Jacobs, B., Waters, R, Langland, J. (2010). Spectrum of antimicrobial activity associated with colloidal silver. J. Med. Micro. (submitted).


2009

  1. Jacobs, B., Langland, J., Kibler, K., Denzler, K., Holecheck, S., White, S., Lanzter, S., Huynh, T., and Baskin, C. (2009). Vaccinia virus vaccines: past, present and future Antiviral Res..

  2. Zhang P, Langland JO, Jacobs BL, Samuel CE. (2009) Protein kinase PKR-dependent activation of mitogen- activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. J Virol. 83:5718-25


2008

  1. Jentarra, G.M., Heck, M.C., Youn, J.W., Kibler, K., Langland, J.O., Baskin, C.R., Ananieva, O., Chang, Y., and Jacobs, B.L. (2008) Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination. Vaccine, 26:2860-72

  2. Langland, J., Waters, R., and Rochon, Metabolic genetic expression analysis of Astragalus sp. herbal extract on ex vivo immuno-stimulated human peripheral blood mononuclear cells Y. Int. J. Nat. Med., AANP Convention Proceedings, 2008, 316-319.


2007

  1. Ye, Y., Hauns, K, Langland, J.O., Jacobs, B.L. and Hogue, B.G. (2007). Mouse hepatitis coronavirus A59 nucleocapsid protein is a type I interferon antagonist. J. Virol. 81:2554-2563.


2006

  1. Langland, J.O., Kash, J.C., Carter, V., Thomas, M.J., Katze, M.G., and Jacobs, B.L. (2006). Suppression of Proinflammatory Signal Transduction and Gene Expression by the Dual Nucleic Acid Binding Domains of the Vaccinia Virus E3L Proteins. J. Virology 80: 10083-10095.

  2. Langland, J.O., Cameron, J.M, Heck, M.C., Jancovich, J.K. and Jacobs, B.L. (2006). Inhibition of PKR by RNA and DNA Viruses. Virus Research 119: 100-110.


2005

  1. Langland, J.O., Lancaster, V., and Jacobs, B.L. (2005). Viral Countermeasures to the Host Interferon Response: Role of the Vaccinia Virus E3L and K3L Genes. Antiviral Drug Discovery for Emerging Diseases and Bioterrorism Threats. Editor: P.A. Torrence; John Wiley and Sons, Inc.


2004

  1. Langland, J.O. and Jacobs, B.L. (2004). Inhibition of PKR by Vaccinia Virus: Role of the N- and C-Terminal Domains of E3L. J. Virology 324: 419-429.


2003

  1. Langland, J.O. Kao, P., and Jacobs, B.L. (2003). Regulation of IL-2 Gene Expression and Nuclear Factor-90 Translocation in Vaccinia Virus-Infected Cells. J. Interferon Cytokine Res. 23:489-500.

  2. Vijaysri, S., Talasela, L., Mercer, A.A., Mcinnes, C.J., Jacobs, B.L., and Langland, J.O., (2003). The Orf Virus E3L Homologue is Able to Complement Deletion of the Vaccinia Virus E3L Gene in vitro but no in vivo. Virology 15:305-314.


2002

  1. Langland, J.O., and Jacobs, B.L. (2002). The Role of the PKR Inhibitory Genes, E3L and K3L, in Determining Vaccinia Virus Host Range. Virology 299:133-141.


2001

  1. He, Y., Tan, S.L., Tareen, S.U., Vijaysri, S., Langland, J.O., Jacobs, B.L. and Katze, M.G. (2001). Regulation of mRNA Translation and Cellular Signaling by Hepatitis C Virus Nonstructural Protein NS5A. J. Virol. 75: 5090-5098.


Prior to 2000

  1. Langland, J.O., Kao, P.N. and Jacobs, B.L. (1999). Nuclear Factor-90 of Activated T-Cells: A Double-Stranded RNA-Binding Protein and Substrate for the Double-Stranded RNA-Dependent Protein Kinase, PKR. Biochemistry 38:6361-6368.

  2. Langland, J.0., Langland, L.A. and Roth, D.A. (1998). Differential Location and Accumulation of the Plant Double- Stranded RNA Dependent Protein Kinase During Virus Infection Plant Physiology and Biochemistry, 36:395-400.

  3. Jacobs, B.L. and Langland, J.O. (1998). Reovirus Sigma3 Protein: dsRNA-Binding and Inhibition of PKR. CTMI, Springer-Verlag, Berlin, pp 185-196.

  4. Jacobs, B.L., Langland. J.O. and Brandt, T. (1998). Characterization of Double-stranded RNA-Binding Proteins. Methods, 15, 225-232.

  5. Rager, K.J., Langland, J.O., Jacobs, B.L., Marsh, D.G. and Imani, F. (1998) Activation of Anti-Viral Protein Kinase (PKR) Leads to IgE Class Switching in Human B Cells. J. Virology, 72:1171-1176.

  6. Langland, J.0., Langland, L.A., Gupta, N. and Roth, D.A. (1997). Developmental Regulation of a Plant-Encoded Inhibitor of eIF-2 PlaKnitnJaosuernAaclt,i1v2it:y.393-400.

  7. Langland, J.O. and Jacobs, B.L. (1997). Viral inhibitors of interferon action: inhibitors of the PKR and 2'5' oligoadenylate synthetase/RNase L pathways. In: "Gamma Interferon in Antiviral Defense". G. Karupiah, ed. R.G. Landes, Texas.

  8. Kibler, K., Shors, T, Perkins, K.B. Zeman, C.C., Banaszak, M.P. Biesterfeldt, J., Langland, J.0., and Jacobs, B. (1997). Double-Stranded RNA as a Trigger for Apoptosis in Vaccinia Virus Infected Cells. J. Virology, 71: 1922-2005.

  9. Langland, J.0., Langland, L.A., Browning, K.S. and Roth, D.A. (1996). Phosphorylation of the Plant Eukaryotic Initiation Factor-2 by the Plant-Encoded Double-Stranded RNA-Dependent Protein Kinase, pPKR, and Inhibition of Protein Synthesis In Vitro. J. Biol. Chem., 271: 4539-4544.

  10. Langland, J.0., Langland, L.A. and Roth, D.A. (1996). Polyanion Regulation of the Plant-Encoded dsRNA- Dependent Protein Kinase, pPKR. Plant Phys. and Biochem, 34: 521-526.

  11. Roth, D.A. and Langland, J.0. (1996). Functional Significance of Plant Encoded dsRNA Dependent Protein Activity in the Regulation of Protein Synthesis. Current Top. in Plant Biochem. Mol. Biol., 15: 77-78.

  12. Jacobs, B. and Langland, J.0. (1996). When Two Stands are Better Than One: The Modulators and Mediators of Double-Stranded RNA. Virology, 219: 339-349.

  13. Langland, J.0., Jacobs, B.L. and Roth, D.A. Identification of a Plant-Encoded Analog of PKR, the Mammalian Interferon-Induced, Double-Stranded RNA-Dependent Protein Kinase. (1995). Plant Physiol, 108: 1259- 1267.

  14. Langland, J.0., Pettiford, S., Jiang, B. and Jacobs, B.L. (1994). Products of the Porcine Rotavirus Group C NSP3 Gene Bind Specifically to Double-Stranded RNA and Regulate Activation of the Interferon-Induced Protein Kinase, PKR. J. Virology 68:3821-3829.

  15. Langland, J.0., Pettiford, S. and Jacobs, B.L. (1994). Nucleic Acid Affinity Chromatography: Preparation and Characterization of Double-Stranded RNA Agarose. Protein Expression and Purification 6: 25-32.

  16. Park, H., Davies, M.V., Langland, J.0., Chang, H.W., Nam, Y.S., Tartaglia, J., Paoletti, E., Jacobs, B.L. Kaufman, R.J. and Venkatesan, S. (1994). A Cellular Protein That Binds Several Structured Viral RNAs is an Inhibitor of the Interferon-induced PKR Protein Kinase in vitro and in vivo. Proc. Natl. Acad. Sci. USA 91: 4713- 4717.

  17. Langland, J.0. and Jacobs, B.L. (1992). Cytosolic Double-stranded RNA-dependent Protein Kinase Is Likely a Dimer of Partially Phosphorylated Mr=66,000 Subunit. J. Biol. Chem. 267: 10729-10736.

  18. Langland, J.O., and Jacobs, B.L. Kidney Cell Expression of an Endogenous Inhibitor of the PKR-Mediated Antiviral Response. Virology (in preparation).


OTHER PUBLICATIONS:

  1. Langland, J.O. and Waters, R.F. (2010). Rediscovery of a 19th Century Cure for Smallpox. SCNM Now Spring 2010, 16-17.

  2. Langland, J.O. and Waters, R.F. (2009). Breaking news in research. SCNM Now Fall 2009, 14-16.

  3. Langland, J.O. and Waters, R.F. (2008). SCNM Research Department Collaborates with Arizona State University/Biodesign Institute, Translational Genomics Institute and the University of Arizona; SCNM Students First in the Profession to Perform Genetic Expression Analysis. SCNM Now 4: 1-8.