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  1. Veneziano R, Ratanalert S, Zhang K, Zhang F, Yan H, Chiu W, Bathe M. Science. 2016 May 26. pii: aaf4388. [Epub ahead of print] Designer nanoscale DNA assemblies programmed from the top down.

  2. Dhakal S, Adendorff MR, Liu M, Yan H, Bathe M, Walter NG. Nanoscale. 2016 Feb 7;8(5):3125-37. doi: 10.1039/c5nr07263h. Rational design of DNA-actuated enzyme nanoreactors guided by single molecule analysis.


  1. Zhang, F.; Jiang, S.; Wu, S.; Li, Y.; Mao, C.; Liu, Y.; Yan, H., Complex wireframe DNA origami nanostructures with multi-arm junction vertices. Nat Nanotechnol 2015, 10 (9), 779-84;

  2. Yang, Y. R.; Liu, Y.; Yan, H., DNA Nanostructures as Programmable Biomolecular Scaffolds. Bioconjug Chem 2015, 26 (8), 1381-95;

  3. Georges, J. F.; Liu, X.; Eschbacher, J.; Nichols, J.; Mooney, M. A.; Joy, A.; Spetzler, R. F.; Feuerstein, B. G.; Preul, M. C.; Anderson, T.; Yan, H.; Nakaji, P., Use of a conformational switching aptamer for rapid and specific ex vivo identification of central nervous system lymphoma in a xenograft model. PLoS One 2015, 10 (4), e0123607;


  1. Zhang, F.; Nangreave, J.; Liu, Y.; Yan, H., Structural DNA nanotechnology: state of the art and future perspective. J Am Chem Soc 2014, 136 (32), 11198-211;

  2. Wang, D.; Capehart, S. L.; Pal, S.; Liu, M.; Zhang, L.; Schuck, P. J.; Liu, Y.; Yan, H.; Francis, M. B.; De Yoreo, J. J., Hierarchical assembly of plasmonic nanostructures using virus capsid scaffolds on DNA origami templates. ACS Nano 2014, 8 (8), 7896-904;

  3. Seeman, N. C.; Mao, C.; Yan, H., Guest editorial: nucleic acid nanotechnology. Acc Chem Res 2014, 47 (6), 1643-4;

  4. Samanta, A.; Zhou, Y.; Zou, S.; Yan, H.; Liu, Y., Fluorescence quenching of quantum dots by gold nanoparticles: a potential long range spectroscopic ruler. Nano Lett 2014, 14 (9), 5052-7;

  5. Pan, K.; Kim, D. N.; Zhang, F.; Adendorff, M. R.; Yan, H.; Bathe, M., Lattice-free prediction of three-dimensional structure of programmed DNA assemblies. Nat Commun 2014, 5, 5578;

  6. Liang, L.; Li, J.; Li, Q.; Huang, Q.; Shi, J.; Yan, H.; Fan, C., Single-particle tracking and modulation of cell entry pathways of a tetrahedral DNA nanostructure in live cells. Angewandte Chemie 2014, 53 (30), 7745-50;

  7. Li, W.; Yang, Y.; Jiang, S.; Yan, H.; Liu, Y., Controlled nucleation and growth of DNA tile arrays within prescribed DNA origami frames and their dynamics. J Am Chem Soc 2014, 136 (10), 3724-7;

  8. Johnson-Buck, A.; Jiang, S.; Yan, H.; Walter, N. G., DNA-cholesterol barges as programmable membrane-exploring agents. ACS Nano 2014, 8 (6), 5641-9;

  9. Jiang, S.; Yan, H.; Liu, Y., Kinetics of DNA tile dimerization. ACS Nano 2014, 8 (6), 5826-32;

  10. Fu, J.; Yang, Y. R.; Johnson-Buck, A.; Liu, M.; Liu, Y.; Walter, N. G.; Woodbury, N. W.; Yan, H., Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm. Nat Nanotechnol 2014, 9 (7), 531-6;

  11. Flory, J. D.; Simmons, C. R.; Lin, S.; Johnson, T.; Andreoni, A.; Zook, J.; Ghirlanda, G.; Liu, Y.; Yan, H.; Fromme, P., Low temperature assembly of functional 3D DNA-PNA-protein complexes. J Am Chem Soc 2014, 136 (23), 8283-95;

  12. Edwards, A.; Yan, H., DNA Origami. In Nucleic Acid Nanotechnology, Kjems, J.; Ferapontova, E.; Gothelf, K. V., Eds. 2014; Vol. 29, pp 93-133;

  13. Dutta, P. K.; Lin, S.; Loskutov, A.; Levenberg, S.; Jun, D.; Saer, R.; Beatty, J. T.; Liu, Y.; Yan, H.; Woodbury, N. W., Reengineering the optical absorption cross-section of photosynthetic reaction centers. J Am Chem Soc 2014, 136 (12), 4599-604;

  14. Dutta, P. K.; Levenberg, S.; Loskutov, A.; Jun, D.; Saer, R.; Beatty, J. T.; Lin, S.; Liu, Y.; Woodbury, N. W.; Yan, H., A DNA-directed light-harvesting/reaction center system. J Am Chem Soc 2014, 136 (47), 16618-25.


  1. A. Johnson-Buck, J. Nangreave, D. Kim, M. Bathe, H. Yan, N. Walter. Super-Resolution Fingerprinting Detects Chemical Reactions and Idiosyncrasies of Single DNA Pegboards. Nano Letters.

  2. A. Johnson-Buck, J. Nangreave, S. Jiang, H. Yan, N. Walter. Multifactorial Modulation of Binding and Dissociation Kinetics on Two-Dimensional DNA Nanostructures. Nano Letters.

  3. D. Han, S. Jiang, A. Samanta, Y. Liu, H.Yan. Unidirectional Scaffold-Strand Arrangement in DNA Origami. Angew Chem Int Ed.

  4. D. Han, S. Pal, Y. Yang, S. Jiang, J. Nangreave, Y. Liu, H. Yan. DNA Gridiron Nanostructures Based on Four-Arm Junctions. Science.

  5. F. Zhang, Y. Liu, H. Yan. Complex Archimedean Tiling Self-assembled from DNA Nanostructures. J. Am. Chem. Soc.

  6. J. Flory, S. Shinde, S. Lin, Y. Liu, H. Yan, G. Ghirlanda, P. Fromme. PNA-peptide Assembly in a 3D DNA Nanocage at Room Temperature. J. Am. Chem. Soc.

  7. M. Liu, J. Fu, C. Hejesen, Y. Yang, N. W. Woodbury, K. Gothelf, Y. Liu, H. Yan. A DNA Tweezer-Actuated Enzyme Nanoreactor. Nature Communications.

  8. O. Schulz, Z. Zhao, A. Ward, M. Koenig, F. Koberling, Y. Liu, J. Enderlein, H. Yan and R. Ros. Tip Induced Fluorescence Quenching for Nanometer Optical and Topographical Resolution. Optical Nanoscopy.

  9. Q. Mei, R. H. Johnson, X. Wei, F. Su, Y. Liu, L. Kelbauskas, S. Lindsay, D. R. Meldrum, and H. Yan. On-chip isotachophoresis separation of functional DNA origami capture nanoarrays from cell lysate. Nano Research.

  10. S. Pal, P. Dutta, H. Wang, Z. Deng, S. Zou, H. Yan, Y. Liu. Quantum Efficiency Modification of Organic Fluorophores Using Gold Nanoparticles on DNA Origami Scaffolds. J. Phys. Chem. C.

  11. W. Li, Y. Yang, H. Yan, Y. Liu. 3-Input Majority Logic Gate and Multiple Input Logic Circuit Based on DNA Strand Displacement. Nano Letters.

  12. X. Liu, Y. Liu, H. Yan. Functionalized DNA Nanostructures for Nanomedicine. Israel Journal of Chemistry.

  13. X. Wei, J. Nangreave, S. Jiang, H. Yan, Y. Liu. Mapping the Thermal Behavior of DNA Origami Nanostructures. J. Am. Chem. Soc.

  14. Y. Yang, Z. Zhao, F. Zhang, J. Nangreave, Y. Liu, H. Yan. Self-assembly of DNA Rings from Scaffold Free DNA Tiles. Nano Letters.

  15. Z. Deng, S. Pal, A. Samanta, H. Yan, Y. Liu. DNA Functionalization of Colloidal II-VI Semiconductor Nanowires. Chemical Sciences.

  16. Z. Zhao, Y. Liu, H. Yan. DNA Origami Templated Self-assembly of Discrete Length Single Wall Carbon Nanotubes. Org. Biomol. Chem.


  1. A. V. Pinheiro, J. Nangreave, S, Jiang, H. Yan, Y. Liu. Steric Crowding and the Kinetics of DNA Hybridization within a DNA Nanostructure System. ACS Nano.

  2. F. Zhang, J. Nangreave, Y. Liu, H. Yan. Reconfigurable DNA Origami to Generate Quasi-Fractal Patterns. Nano Letters.

  3. J. Fu, H. Yan. Controlled Drug Release by a Nanorobot. Nature Biotechnology.

  4. J. Fu, M. Liu, Y. Liu, H. Yan. Spatially-Interactive Biomolecular Networks Organized by Nucleic Acid Nanostructures. Acc. Chem. Res.

  5. J. Fu, M. Liu, Y. Liu, N. W. Woodbury, H. Yan. Interenzyme Substrate Diffusion for an Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures. J. Am. Chem. Soc.

  6. N. Lu, H. Pei, Z. Ge, C. R. Simmons, H. Yan, C. Fan. Charge Transport within A Three-Dimensional DNA nanostructure Framework. J. Am. Chem. Soc (2012).

  7. Q. Jiang, C. Song, J. Nangreave, X. Liu, L. Lin, D. Qiu, Z. Wang, G. Zou, X. Liang, H. Yan, B. Ding. DNA Origami as a Carrier for Circumvention of Drug Resistance. J. Am. Chem. Soc.

  8. X. Liu, Y. Xu, T. Yu, C. Craig, Y. Liu, H. Yan, Y. Chang. A DNA Nanostructure Platform for Directed Assembly of Synthetic Vaccines,. Nano Letters.

  9. Y. Yang, D. Han, J. Nangreave, , Y. Liu, H. Yan,. DNA Origami with Double-Stranded DNA As a Unified Scaffold. ACS Nano.

  10. Z. Deng, A. Sanmanta, J. Nangreave, H. Yan, Y. Liu. Robust DNA Functionalized Core/Shell Quantum Dots with Fluorescent Emission Spanning from UV-Vis to Near IR and Compatible with DNA Directed Self-Assembly. J. Am. Chem. Soc.

  11. Z. Li, L. Wang, H. Yan, Y. Liu. Effect of DNA Hairpin Loops on the Twist of Planar DNA Origami Tiles. Langmuir.

  12. J. Fu, H. Yan. Controlled Drug Release by a Nanorobot. Nature Biotechnology.


  1. A. Pinheiro, D. Han, W. M. Shih,*, H. Yan*. Challenges and Opportunities for Structural DNA Nanotechnology. Nature Nanotechnology.

  2. D. Han*, S. Pal, J. Nangreave, Z. Deng, Y. Liu*, H. Yan*. DNA Origami with Complex Curvatures in Three-dimensional Space. Science.

  3. J. Nangreave, H. Yan, Y. Liu*. DNA Nanostructures as Models for Evaluating the Role of Enthalpy and Entropy in Polyvalent Binding. J. Am. Chem. Soc.

  4. P. Dutta, R. Varghese, S. Lin, H. Yan, Y. Liu*. DNA Directed Artificial Light Harvesting Systems. J. Am. Chem. Soc.

  5. Q. Mei, X. Wei, F. Su, Y. Liu, C. Youngbull, R. Johnson, S. Lindsay, H. Yan*, D. Meldrum*. Stability of DNA Origami Nanoarrays in Cell Lysate. Nano Letters.

  6. S. Pal, Z. Deng, Y. Liu*, H. Yan*. DNA Origami Directed Self-assembly of Anisotropic Plasmonic Nanostructures.. J. Am. Chem. Soc.

  7. S.Pal, R. Varghese, H. Yan*, Y. Liu*. Site Specific Synthesis and in-situ Immobilization of Fluorescent Silver Nanoclusters on DNA Nanoscaffolds Using Tollens Reaction. Angew Chem Int Ed.

  8. T. Torring, N. V. Voigt, J. Nangreave, H. Yan*, K. Gothelf*. DNA Origami: A quantum leap for self-assembly of complex structures. Chem. Soc. Rev.

  9. X. Liu, H. Yan, Y. Liu*, Y. Chang*. Targeted Cell-Cell Interactions by DNA Nanoscaffold-Templated Multivalent Bi-specific Aptamers. Small.

  10. Z. Deng, L. Tong, S. Lin, M. Flores, J. Cheng, H. Yan, Y. Liu*. High Quality Manganese-Doped Zinc Sulfide Quantum Rods with Tunable Dual-Color and Multi-Photon Emissions. J. Am. Chem. Soc.

  11. Z. Zhao, Y. Liu*, H. Yan*. Encapsulation of Gold Nanoparticles in a DNA Origami Cage. Angew Chem Int Ed..