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* denotes corresponding author; ‡ denotes student/postdoctoral fellow/visiting scholar mentored by Gu; + denotes co-first author


  1. X. Shi‡, S. Wang‡, P. Jasbi‡, C. Turner‡, J. Hrovat‡, Y. Wei‡, J. Liu‡, and H. Gu*, "Database Assisted Globally Optimized Targeted Mass Spectrometry (dGOT-MS): Broad and Reliable Metabolomics Analysis with Enhanced Identification", Anal. Chem., 21, 13737-13745, 2019, PMID: 31556994

  2. P. Jasbi‡, O. Baker, X. Shi‡, L. Gonzalez, S. Wang‡, S. Anderson, B. Xi, H. Gu*, C. Johnston*, “Daily red wine vinegar ingestion for eight weeks improves glucose homeostasis and affects the metabolome but does not reduce adiposity in adults”, Food Funct., 10, 7343, 2019. PMID: 31647087

  3. X. Wang+‡, H. Gu+, S. Palma-Duran, A. Fierro, P. Jasbi‡, X. Shi‡, W. Bresette‡, N. Tasevska*, “Influence of Storage Conditions and Preservatives on Metabolite Fingerprints in Urine”, Metabolites, 9, 203, 2019. PMCID: PMC6836253

  4. D. Scoville, C. Y. Li, D. Wang‡, J. L. Dempsey, D. Raftery, S. Mani, H. Gu*, J. Y. Cui*, “Polybrominated Diphenyl Ethers and Gut Microbiome Modulate Metabolic Syndrome-Related Aqueous Metabolites in Mice”, Drug Metab Dispos, 47, 928-940, 2019. PMID: 31123037

  5. P. Jasbi‡, N. M. Mitchell, X. Shi‡, T. E. Grys, Y. Wei‡, L. Liu‡, D. F. Lake, H. Gu*, "Coccidioidomycosis Detection Using Targeted Plasma and Urine Metabolic Profiling", J. Proteome Res., 18, 72791-2802, 2019. PMID: 31244214

  6. J. Liu‡, P. D. Hanavan, K. Kras, Y. W. Ruiz, E. P. Castle, D. F. Lake, X. Chen, D. O’Brien, H. Luo, K. D. Robertson, H. Gu*, T. H. Ho*, “Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation”, J. Proteome Res., 18, 331-340, 2019. PMID: 30406665

  7. P. Jasbi‡, D. Wang‡, L. Cheng, Q. Fei‡, Y. Cui, L. Liu, Y. Wei‡, D. Raftery, H. Gu*, “Breast cancer detection using targeted plasma metabolomics”, J. Chromatogr. B, 1105, 26-37, 2019. PMID: 30562627

  8. Q. Fei‡, D. Wang‡, P. Jasbi‡, P. Zhang‡, G. A. Nagana Gowda, D. Raftery*, H. Gu*, "Combining NMR and MS with Chemical Derivatization for Absolute Quantification with Reduced Matrix Effects", Anal. Chem., 91, 4055-4062, 2019. PMID: 30801179

  9. D. Bearden, D. Sheen*, Y. Simon-Manso, B. Benner, W. Rocha, N. Blonder, K. Lippa, R. Beger, L. Schnackenberg, J. Sun, K. Mehta, A. Cheema, H. Gu, R. Marupaka, G. Gowda, D. Raftery, “Metabolomics Test Materials for Quality Control: A Study of a Urine Materials Suite”, Metabolites, 9, 270, 2019. PMCID: PMC6918257

  10. G. Kurgan, L. Kurgan, A. Schneider, M. Onyeabor, Y. Rodriguez-Sanchez, E. Taylor, R. Martinez, P. Carbonell, X. Shi‡, H. Gu, X. Wang*, “Identification of major malate export systems in an engineered malate-producing Escherichia coli aided by substrate similarity search”, Appl Microbiol Biotechnol., 103, 9001, 2019. PMID: 31641813

  11. D. Gutierrez, A. Weinstock, V. Antharam, H. Gu, P. Jasbi‡, X. Shi‡, B. Dirks, R. Krajmalnik-Brown, J. Maldonado, J. Guinan, S. Thangamani*, "Antibiotic-induced gut metabolome and microbiome alterations increase the susceptibility to Candida albicans colonization in the gastrointestinal tract," FEMS Microbiol. Ecol., 96, pii: fiz187, 2019, PMCID: PMC6934136

  12. S. Navarro, A. Tarkhan, A. Shojaie, T. Randolph, H. Gu, D. Djukovic, K. Osterbauer, M. Hullar, M. Kratz, M. Neuhouser, P. Lampe, D. Raftery, J. Lampe*, “Plasma metabolomics profiles suggest beneficial effects of a low-glycemic load dietary pattern on inflammation and energy metabolism”, Am J Clin Nutr., 110, 984, 2019. PMCID: PMC6766441

  13. J. Dempsey, D. Wang‡, G. Siginir, Q. Fei‡, D. Raftery, H. Gu, J. Y. Cui*, “Pharmacological Activation of PXR and CAR Downregulates Distinct Bile Acid-Metabolizing Intestinal Bacteria and Alters Bile Acid Homeostasis”, Toxicol Sci., 168, 40-60, 2019. PMID: 30407581

  14. D. Wang‡, S. Cheng, Q. Fei‡, H. Gu, D. Raftery, B. Cao, X. Sun, J. Yan, C. Zhang, J. Wang*, “Metabolic profiling identifies phospholipids as potential serum biomarkers for schizophrenia”, Psychiatry Res., 272, 18-29, 2019. PMID: 30579177

  15. X. Zhang, X. Xie, B. Heckmann, A. Saarinen, H. Gu, R. Zechner, J. Liu*, "Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)", FASEB J., 33, 6655-6666, 2019. PMID: 30802154

  16. B. Zhu, H. Cao, G. Li, W. Du, G. Xu, J. Santo Domingo, H. Gu, N. Xu, S. Duan, J. Lu*, "Biodiversity and dynamics of cyanobacterial communities during blooms in temperate lake (Harsha Lake, Ohio, USA)", J. Harmful Algae, 82, 9-18, 2019. PMID 30928013

  17. E. Quarles, N. Basisty, Y. Chiao, G. Merrihew, H. Gu, M. Sweetwyne, J. Fredrickson, N. Nguyen, M. Razumova, K. Kooiker, F. Moussavi-Harami, M. Regnier, C. Quarles, M. MacCoss, P. Rabinovitch*, “Rapamycin persistently improves cardiac function in aged, male and female mice, even following cessation of treatment”, Aging Cell, e13086, 2019. PMID: 31823466

  18. A. Pilon, H. Gu, D. Raftery, V. Bolzani, N. Lopes, I. Castro-Gamboa, F. Neto*, “Mass Spectral Similarity Networking and Gas-Phase Fragmentation Reactions in the Structural Analysis of Flavonoid Glycoconjugates”, Anal. Chem., 91, 10413, 2019. PMID: 31313915

  19. R. Burr, H. Gu, K. Cain, D. Djukovic, X. Zhang, C. Han, N. Callan, D. Raftery, M. Heitkemper*, “Tryptophan Metabolites in Irritable Bowel Syndrome: An Overnight Time-course Study”, J Neurogastroenterol Motil., 25, 551, 2019. PMCID: PMC6786437


  1. C. Li, J. L. Dempsey, D. Wang‡, S. Lee, K. M. Weigel, Q. Fei‡, D. K. Bhatt, B. Prasad, D. Raftery, H. Gu*, J. Y. Cui*, “PBDEs Altered Gut Microbiome and Bile Acid Homeostasis in Male C57BL/6 Mice”, Drug Metab. Dispos., 46, 1226-1240, 2018. PMCID: PMC6053593

  2. D. Wang‡, X. Sun, J. Yan, B. Ren, B. Cao, Q. Lu, Y. Liu, J. Zeng, N. Huang, Q. Xie, H. Gu*, J. Wang*, “Alterations of eicosanoids and related mediators in patients with schizophrenia”, J Psychiatr. Res., 102:168-178, 2018. PMID: 29674269

  3. P. Lohavanichbutr, Y. Zhang, P. Wang, H. Gu, G. A. N. Gowda, D. Djukovic, M. Buas, D. Raftery, C. Chen*, “Salivary metabolite profiling distinguishes patients with oral cavity squamous cell carcinoma from normal controls”, PLoS One, e0204249, 2018. PMCID: PMC6147497

  4. B. Roshanravan, L. Zelnick, D. Djucovic, H. Gu, J. Alvarez, T. Ziegler, J. Gamboa, K. Utzschneider, B. Kestenbaum, J. Himmelfarb, S. Kahn, D. Raftery, I. de Boer*, “Chronic kidney disease attenuates the plasma metabolome response to insulin”, JCI Insight, 3, e122219, 2018. PMCID: PMC6141172

  5. R. Centini, M. Tsang, T. Iwata, H. Park, J. Delrow, D. Margineantu, B. Iritani, H. Gu, H. Liggitt, J. Kang, L. Kang, D. Hockenbery, D. Raftery, B. Iritani*, “Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation”, PLoS One, e0197973, 2018. PMCID: PMC5999084  

  6. D. Du‡, H. Gu, D. Djukovic, L. Bettcher, M. Gong‡, W. Zheng, L. Hu, X. Zhang, R. Zhang, D. Wang‡, D. Raftery*, “Multiplatform Metabolomics Investigation of Antiadipogenic Effects on 3T3-L1 Adipocytes by a Potent Diarylheptanoid”, J. Proteome Res., 17, 2092-2101, 2018. PMID: 29688022

  7. D. Shao, O. Villet, Z. Zhang, S. Choi, J. Yan, J. Ritterhoff, H. Gu, D. Djukovic, D. Christodoulou, S. Kolwicz, D. Raftery, R. Tian*, “Glucose promotes cell growth by suppressing branched-chain amino acid degradation”, Nat. Commun., 9, 2935, 2018. PMCID: PMC6062555

  8. B. N. R. Ginos, S. L. Navarro, Y. Schwarz, H. Gu, D. Wang, T. W. Randolph, A. Shojaie, M. A. J. Hullar, P. D. Lampe, M. Kratz, M. L. Neuhouser, D. Raftery, J. W. Lampe, “Circulating bile acids in healthy adults respond differently to a dietary pattern characterized by whole grains, legumes and fruits and vegetables compared to a diet high in refined grains and added sugars: A randomized, controlled, crossover feeding study”, Metabolism, 83,197-204, 2018. PMCID: PMC5960615 

  9. R. J. Davis, M. Gönen, D. H. Margineantu, S. Handeli, J. Swanger, P. Hoellerbauer, P. J. Paddison, H. Gu, D. Raftery, J. E. Grim, D. M. Hockenbery, A. A. Margolin, B. E. Clurman, “Pan-cancer transcriptional signatures predictive of oncogenic mutations reveal that Fbw7 regulates cancer cell oxidative metabolism”, PNAS, 115, 5462-5467, 2018. PMID: 29735700

  10. G. A. N. Gowda, D. Djukovic, L. Bettcher, H. Gu, D. Raftery*, “NMR-Guided Mass Spectrometry for Absolute Quantitation of Human Blood Metabolites”, Anal. Chem., 90, 2001-2009, 2018. PMID: 29293320

  11. R. Li, S. Grimm, D. Mav, H. Gu, D. Djukovic, R. Shah, B. Merrick, D. Raftery, P. Wade*, “Transcriptome and DNA Methylome Analysis in a Mouse Model of Diet-Induced Obesity Predicts Increased Risk of Colorectal Cancer”, Cell Rep., 624-637, 2018. PMCID: PMC5793878  


  1. C. Chen, G. A. N. Nagana, J. Zhu, L. Deng, H. Gu, E. G. Chiorean, M. Abu Zaid, M. Harrison, D. Zhang, M. Zhang*, D. Raftery*, “Altered metabolite levels and correlations in patients with colorectal cancer and polyps detected using seemingly unrelated regression analysis”, Metabolomics, 12, 125, 2017.   

  2. J. R. Chao*, K. Knight, A. L. Engel, C. Jankowski, Y. Wang, M. A. Manson, H. Gu, D. Djukovic, D. Raftery, J. B. Hurley, J. Du*, “Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side”, J. Bio. Chem., 292, 12895-12905, 2017. PMCID: PMC5546030

  3. F. Miles, S. Navarro, Y. Schwarz, H. Gu, D. Djukovic, T. Randolph, A. Shojaie, M. Kratz, M. Hullar, P. Lampe, M. Neuhouser, D. Raftery, J. Lampe*, “Plasma metabolite abundances are associated with urinary enterolactone excretion in healthy participants on controlled diets”, Food Funct., 8, 3209-3218, 2017. PMID: 28808723

  4. M. Buas, H. Gu, D. Djukovic, J. Zhu, L. Onstad, B. Reid, D. Raftery*, T. Vaughan*, “Candidate serum metabolite biomarkers for differentiating gastroesophageal reflux disease, Barrett's esophagus, and high-grade dysplasia/esophageal adenocarcinoma”, Metabolomics, 13, 23, 2017. PMCID: PMC5295138

  5. H. Lu, H. Zhu*, T. Zhu, Y. Xiao, S. Xie, H. Gu, M. Cui, L. Luo, “Metabolic Effects of Clenbuterol and Salbutamol on Pork Meat Studied Using Internal Extractive Electrospray Ionization Mass Spectrometry”, Sci. Reports, 7, 5136, 2017. PMCID: PMC5506000.

  6. T. Li, Z. Zhang, S. Kolwicz, L. Abell, N. Roe, M. Kim, B. Zhou, Y. Cao, J. Ritterhoff, H. Gu, D. Raftery, H. Sun, R. Tian*, “Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury”, Cell Metab., 25, 374-385, 2017. PMCID: PMC5301464. 

  7. J. Rabinowitz, A. Robitaille, Y. Wang, C. Ray, R. Thummel, H. Gu, D. Djukovic, D. Raftery, J. Berndt, R. Moon*, “Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish”, PNAS, 114, E717-E726, 2017. PMCID: PMC5293114.


  1. F. Carnevale Neto, A. C. Pilon, D. M. Selegato, R. T. Freire, H. Gu, D. Raftery, N. P. Lopes*, I. Castro-Gamboa*, “Dereplication of Natural Products Using GC-TOF Mass Spectrometry: Improved Metabolite Identification by Spectral Deconvolution Ratio Analysis”, Front. Mol. Biosci., 3, 59, 2016. PMCID: PMC5044510

  2. H. Zhao, J. Shen, D. Djukovic, C. Daniel-MacDougall, H. Gu, X. Wu, W. H. Chow, “Metabolomics-identified metabolites associated with body mass index and prospective weight gain among Mexican American women”, Obes. Sci. & Pract., 2, 309-317, 2016. PMCID: PMC5043515

  3. H. Gu, J. Du, P. A. Carroll, J. Zhu, F. Carnevale Neto, R. N. Eisenman, D. Raftery*, “Quantitative Method to Investigate the Balance between Metabolism and Proteome Biomass: Starting from Glycine”, Angew. Chem. Int. Ed., 55, 15656-15650, 2016. PMID: 27860107

  4. B. Parent*, M. Seaton, R. Sood, H. Gu, D. Djukovic, D. Raftery, G. O'Keefe, “Use of Metabolomics to Trend Recovery and Therapy After Injury in Critically Ill Trauma Patients”, JAMA Surg., 151, e160853, 2016. PMID: 27223119

  5. L. Deng+, H. Gu+*, J. Zhu, G. A. Nagana Gowda, D. Djukovic, E. G. Chiorean, D. Raftery*, “Combining NMR and LC/MS Using Backward Variable Elimination: Metabolomics Analysis of Colorectal Cancer, Polyps, and Healthy Controls”, Anal. Chem., 88, 7975-7983, 2016. PMID: 27437783

  6. M. Buas, H. Gu, D. Djukovic, J. Zhu, C. W. Drescher, N. Urban, D. Raftery, C. Li*, “Identification of Novel Candidate Plasma Metabolite Biomarkers for Distinguishing Serous Ovarian Carcinoma and Benign Serous Ovarian Tumors”, Gynecol. Oncol., 140, 138-144, 2016. PMID: 26521694 

  7. M. Heitkemper*, C. Han, M. Jarrett, H. Gu, D. Djukovic, R. Shulman, D. Raftery, W. Henderson, K. Cain, “Serum Tryptophan Metabolite Levels During Sleep in Patients With and Without Irritable Bowel Syndrome (IBS)”, Biol. Res. Nurs., 18, 193-198, 2016. PMID: 26156003

  8. J. Du, A. Rountree, W. M. Cleghorn, L. Contreras, K. J. Lindsay, M. Sadilek, H. Gu, D. Djukovic, D. Raftery, J. Satrústegui, M. Kanow, L. Chan, S. H. Tsang, I. R. Sweet, J. B. Hurley*, “Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina”, J. Bio. Chem., 291, 4698-4710, 2016. PMCID: PMC4813492

  9. Y. Chiao, S. C. Kolwicz, N. Basisty, A. Gagnidze, J. Zhang, H. Gu, D. Djukovic, R. P. Beyer, D. Raftery, M. MacCoss, R. Tian, P. S. Rabinovitch*, “Rapamycin Transiently Induces Mitochondrial Remodeling to Reprogram Energy Metabolism in Old Hearts”, Aging, 8, 314-327, 2016. PMID: 26872208

  10. S. Lim, C. Li, W. Xia, H. Lee, S. Chang, J. Shen, J. Hsu, D. Raftery, D. Djukovic, H. Gu, W. Chang, H. Chang, H. Wang, M. Chen, L. Huo, C. Chen, Y. Wu, A. Sahin, S. Hanash, G. Hortobagyi, M. Hung*, “EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape”, Cancer Res., 76, 1284-1296, 2016. PMCID: PMC4775355 


  1. H. Gu*, P. Zhang, J. Zhu, D. Raftery*, “Globally Optimized Targeted Mass Spectrometry (GOT-MS): Reliable Metabolomics Analysis with Broad Coverage”, Anal. Chem., 87, 12355-12362, 2015. PMID: 26579731

  2. S. Chandrasekaran, C. C. Rittschof, D. Djukovic, H. Gu, D. Raftery, N. D. Price*, G. E. Robinson*, “Aggression is associated with aerobic glycolysis in the honey bee brain”, Genes Brain Behav., 14, 158-166, 2015. PMCID: PMC4449359

  3. H. Sperber, J. Mathieu, Y. Wang, A. Ferreccio, J. Hesson, Z. Xu, K. A. Fischer, A. Devi, D. Detraux, H. Gu, S. L. Battle, M. Showalter, C. Valensisi, J. H. Bielas, N. G. Ericson, L. Margaretha, A. M. Robitaille, D. Margineantu, O. Fiehn, D. Hockenbery, C. A. Blau, D. Raftery, A. A. Margolin, R. D. Hawkins, R. T. Moon, C. B. Ware, H. Ruohola-Baker*, “The Metabolome Regulates the Epigenetic Landscape During Naive-to-Primed Human Embryonic Stem Cell Transition”, Nat. Cell Bio., 17, 1523-1535, 2015. PMCID: PMC4662931

  4. J. Zhu, D. Djukovic, L. Deng, H. Gu, F. Himmati, M. Abu Zaid, E. G. Chiorean, D. Raftery*, “Targeted Serum Metabolite Profiling and Sequential Metabolite Ratio analysis for Colorectal Cancer Progression Monitoring”, Anal. Bioanal. Chem., 407, 7857-7863, 2015. PMID: 26342311

  5. J. Wang, Q. Li, H. Gu, X. Guo, S. Yang*, Z. Wang, “Direct Analysis of Micro Area on Tooth Surface by Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry”, Chem. J. Chin. Univ., 36, 1067-1073, 2015. 

  6. H. Gu*, J. Du, F. Carnevale Neto, P. Carroll, S. Turner, G. Chiorean, R. Eisenman, D. Raftery, “Metabolomics Method to Comprehensively Analyze Amino Acids in Different Domains”, Analyst, 140, 2726-2734, 2015. PMCID: PMC4380628 

  7. P. Carroll, D. Diolaiti, L. McFerrin, H. Gu, D. Djukovic, J. Du, P. Cheng, S. Anderson, M. Ulrich, J. Hurley, D. Raftery, D. Ayer, R. Eisenman*, “Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis”, Cancer Cell, 27, 271-285, 2015. PMCID: PMC4326605

  8. N. Reyes, G. Banks, M. Tsang, D. Margineantu, H. Gu, D. Djukovic, J. Chan, M. Torres, H. Liggitt, D. Hirenallur-S, D. Hockenbery, D. Raftery, B. Iritani*, “Fnip1 Regulates Skeletal Muscle Fiber Type Specification, Fatigue Resistance, and Susceptibility to Muscular Dystrophy”, PNAS, 112, 424-429, 2015. PMCID: PMC4299192

  9. R. Sood, H. Gu, D. Djukovic, L. Deng, M. Ga, L. Muffley, D. Raftery, A. Hocking*, “Targeted Metabolic Profiling of Wounds in Diabetic and Nondiabetic Mice”, Wound Repair Regen., 23, 423-34, 2015. PMID: 25845676

  10. S. Barton, S. Navarro, M. Buas, Y. Schwarz, H. Gu, D. Djukovic, D. Raftery, M. Kratz, M. Neuhouser, J. Lampe*, “Targeted Plasma Metabolome Response to Variations in Dietary Glycemic Load in a Randomized, Controlled, Crossover Feeding Trial in Healthy Adults”, Food Funct., 6, 2949-2956, 2015. PMID: 26165375

  11. S. Pan, Y. Tian, M. Li, J. Zhao, L. Zhu, W. Zhang, H. Gu*, H. Wang, J. Shi, X. Fang, P. Li, H. Chen, “Quantitative Detection of Nitric Oxide in Exhaled Human Breath by Extractive Electrospray Ionization Mass Spectrometry”, Sci. Reports, 5, 8725, 2015. PMCID: PMC4348632

  12. C. Chen, L. Deng, S. Wei, G.A.N. Gowda, H. Gu, E.G. Chiorean, M. Abu Zaid, M. Harrison, J. Pekny, P. Patrick, D. Zhang, M. Zhang*, D. Raftery*, “Exploring Metabolic Profile Differences between Colorectal Polyp Patients and Controls Using Seemingly Unrelated Regression”, J. Proteome Res., 14, 2492-2499, 2015. PMID: 25919433


  1. W. Yao, H. Gu, J. Zhu, G. Barding, H. Cheng, B. Bao, L. Zhang*, A. Ding*, W. Li, “Integrated Plasma and Urine Metabolomics Coupled with HPLC/QTOF-MS and Chemometric Analysis on Potential Biomarkers in Liver Injury and Hepatoprotective Effects of Er-Zhi-Wan”, Anal. Bioanal. Chem., 406, 7367-7378, 2014. PMID: 25245419

  2. J. Zhu, D. Djukovic, L. Deng, H. Gu, F. Himmati, E. Chiorean, D. Raftery*, “Colorectal Cancer Detection Using Targeted Serum Metabolic Profiling”, J. Proteome Res., 13, 4120-4130, 2014. PMID: 25126899

  3. D. Dai, P. Karunadharma, Y. Chiao, N. Basisty, D. Crispin, E. Hsieh, T. Chen, H. Gu, D. Djukovic, D. Raftery, R. Beyer, M. Maccoss, P. Rabinovitch*, “Altered Proteome Turnover and Remodeling by Short-term Caloric Restriction or Rapamycin Rejuvenate the Aging Heart”, Aging Cell, 13, 529-539, 2014. PMCID: PMC4040127


  1. H. Gu, A. N. Gowda, F. Carnevale Neto, M. Opp, D. Raftery*, “RAMSY: Ratio Analysis of Mass Spectrometry to Improve Compound Identification”, Anal. Chem., 85, 10771-10779, 2013. PMCID: PMC3867450

  2. N. Xu, Z. Zhu, S. Yang, J. Wang, H. Gu*, H. Chen, “Direct Detection of Amino Acids Using Extractive Electrospray Ionization Tandem Mass Spectrometry”, Chin. J. Anal. Chem., 41, 523–528, 2013.

  3. H. Baniasadi, A. N. Gowda, H. Gu, A. Zeng, S. Zhuang, N. Skill, M. Maluccio, D. Raftery*, “Targeted Metabolic Profiling of Hepatocellular Carcinoma and Hepatitis C using LC-MS/MS”, Electrophoresis, 34, 2910-2917, 2013. PMCID: PMC3826436 

  4. H. Zhang, H. Gu, F. Yan, N. Wang, Y. Wei, J. Xu, H. Chen*, “Direct Characterization of Bulk Samples by Internal Extractive Electrospray Ionization Mass Spectrometry”, Sci. Reports, 3, 2495, 2013. PMCID: PMC3750536

  5. M. Li, J. Ding, H. Gu, Y. Zhang, S. Pan, N. Xu, H. Chen*, H. Li, “Facilitated Diffusion of Acetonitrile Revealed by Quantitative Breath Analysis Using Extractive Electrospray Ionization Mass Spectrometry”, Sci. Reports, 3, 1205, 2013. PMCID: PMC3564039

  6. Y. Qi, H. Gu, Y. Song, X. Dong, A. Liu, Z. Lou, G. Fan, Y. Chai*, “Metabolomics Study of Resina Draconis on Myocardial Ischemia Rats Using Ultraperformance Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry Combined with Pattern Recognition Methods and Metabolic Pathway Analysis”, Evid. Based Complement. Alternat. Med., 438680, 2013. PMCID: PMC3677627

  7. F. Tayyari, A. N. Gowda, H. Gu, D. Raftery*, “15N-Cholamine-A Smart Isotope Tag for Combining NMR- and MS-Based Metabolite Profiling”, Anal. Chem., 85, 8715-8721, 2013. PMCID: PMC3803152


  1. H. Gu, A. N. Gowda, D. Raftery*, “Metabolic Profiling: Are We en route to Better Diagnostic Tests for Cancer?”, Future Oncol., 8, 1207-1210, 2012. PMID: 23130920

  2. H. Gu, N. Xu, H. Chen*, “Direct Analysis of Biological Samples Using Extractive Electrospray Ionization Mass Spectrometry (EESI-MS)”, Anal. Bioanal. Chem., 403, 2145-2153, 2012. PMID: 22434271

  3. H. Gu, Qi, Y. Qi, N. Xu, J. Ding, Y. An, H. Chen*, “Nuclear Magnetic Resonance Spectroscopy and Mass Spectrometry-Based Metabolomics for Cancer Diagnosis”, Chin. J. Anal. Chem., 40, 1933–1937, 2012.

  4. C. Liu, X. Zhang, S. Xiao, B. Jia, S. Cui, J. Shi, N. Xu, X. Xie, H. Gu*, H. Chen, “Detection of Trace Levels of Lead in Aqueous Liquids Using Extractive Electrospray Ionization Tandem Mass Spectrometry”, Talanta, 98, 79-85, 2012. PMID: 22939131

  5. Z. Zhu, J. Han, Y. Zhan, Y. Zhou, N. Xu, B. Zhang, H. Gu, H. Chen*, “Sensitive Ionization of Non-volatile Analytes Using Protein Solutions as Spray Liquid in Desorption Electrospray Ionization Mass Spectrometry”, Rapid Commun. Mass Spectrom., 26, 2770-2776, 2012. PMID: 23124668


  1. H. Gu, Y. Huang, M. Filgueira, P. W. Carr*, “Effect of First Dimension Phase Selectivity in Online Comprehensive Two Dimensional Liquid Chromatography (LCxLC)”, J. Chrom. A., 1218, 6675-6687, 2011. PMCID: PMC3256932 

  2. H. Gu, Z. Pan, B. Xi, V. Asiago, B. Musselman, D. Raftery*, “Principal Component Directed Partial Least Squares Analysis for Combining NMR and MS Data in Metabolomics: Application to the Detection of Breast Cancer”, Anal. Chim. Acta, 686, 57-63, 2011. PMCID: PMC3040422 

  3. Y. Huang, H. Gu, M. Filgueira, P. W. Carr*, “An Experimental Study of Sampling Time Effects on the Resolving Power of Online Two-Dimensional HPLC”, J. Chrom. A., 1218, 2984-2994, 2011. PMCID: PMC3132878 

  4. B. Hu, S. Yang, M. Li, H. Gu, H. Chen*, “Direct Detection of Native Proteins in Biological Matrices Using Extractive Electrospray Ionization Mass Spectrometry”, Analyst, 136, 3599-3601, 2011. PMID: 21734987


  1. H. Gu, Y. Huang, P. W. Carr*, “Peak Capacity Optimization in Comprehensive Two Dimensional Liquid Chromatography: A Practical Approach”, J. Chrom. A., 1218, 64-73, 2010. PMCID: PMC3034304 

  2. H. Gu, S. Yang, J. Li, B. Hu, H. Chen*, L. Zhang, Q. Fei, “Geometry Independent Neutral Desorption Device Sampling Explosives on Various Surfaces for Sensitive EESI-MS Detection”, Analyst, 135, 779-788, 2010. PMID: 20349542

  3. H. Gu, B. Hu, J. Li, S. Yang, J. Han, H. Chen*, “Rapid Analysis of Aerosol Drugs Using Nano Extractive Electrospray Ionization Tandem Mass Spectrometry”, Analyst, 135, 1259-1267, 2010. PMID: 20498877

  4. B. Hu, X. Peng, S. Yang, H. Gu, H. Chen*, Y. Huan, T. Zhang, X. Qiao, “Fast Quantitative Detection of Cocaine in Beverages Using Nanoextractive Electrospray Ionization Tandem Mass Spectrometry”, J. Am. Soc. Mass Spectrom., 21, 290-293, 2010. PMID: 19939702


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  2. S. Yang, J. Han, Y. Huan, Y. Cui, X. Zhang, H. Chen, H. Gu*, “Desorption Electrospray Ionization Tandem Mass Spectrometry for Rapid Detection of 24 Carcinogenic Aromatic Amines in Textiles”, Anal. Chem., 81, 6070-6079, 2009.

  3. J. Ding, H. Gu, S. Yang, M. Li, J. Li, H. Chen*, “Selective Detection of Diethylene Glycol in Toothpaste Products Using Neutral Desorption Reactive Extractive Electrospray Ionization Tandem Mass Spectrometry”, Anal. Chem., 81:8632-8638, 2009. PMID: 19761215

  4. S. Yang, H. Chen*, Y. Yang, B. Hu, X. Zhang, Y. Zhou, L. Zhang, H. Gu, “Imaging Melamine in Egg Samples by Surface Desorption Atmospheric Pressure Chemical Ionization Mass Spectrometry”, Chin. J. Anal. Chem., 37, 315-318, 2009. 


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  4. Z. Pan, H. Gu, N. Talaty, H. Chen, B. E. Hainline, R. G. Cooks*, D. Raftery*, “Principal Component Analysis of Urine Metabolites Detected by NMR and DESI-MS in Patients with Inborn Errors of Metabolism”, Anal. Bioanal. Chem., 387, 539-549, 2007. PMID: 16821030