Publications

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2019

  1. Wenjun Deng, C.X., Rob David, Diego Mastroeni, MingMing Ning, Eng H Lo, Paul D Coleman, AmpliSeq Transcriptome of Laser Captured Neurons from Alzheimer Brain: Comparison of Single Cell Versus Neuron Pools. Aging and disease, 2019.

  2. Stern, R.A., et al., Tau Positron-Emission Tomography in Former National Football League Players. N Engl J Med, 2019. 380(18): p. 1716-1725.

  3. Roy Lardenoije, J.R., Ehsan Pishva, Markus Leber, Holger Wagner, Artemis Iatrou, Adam Smith, Rebecca Smith, Lars Eijssen, Luca Kleineidam, Amit Kawalia, Per Hoffmann, Tobias Luck, Steffi Riedel-Heller, Frank Jessen, Wolfgang Maier, Michael Wagner, Gunter Kenis, Muhammad Ali, Antonio del Sol, Diego Mastroeni, Elaine Delvaux, Paul Coleman, Jonathan Mill, Bart Rutten, Katie Lunnon, Alfredo Ramirez, Daniël van den Hove, Alzheimer’s Disease DNA (Hydroxy) Methylome in the Brain and Blood: Evidence for OXT Methylation as a Preclinical Marker. Biological Psychiatry, 2019. 85(10): p. S144.

  4. Renjie Liao, M.M., Christopher D Nazaroff, Diego Mastroeni, Paul D Coleman, Jia Guo, Highly sensitive in situ proteomics with cleavable fluorescent tyramide reveals human neuronal heterogeneity. Cold Spring Harbor Laboratory (bioRxiv), 2019.

  5. Renjie Liao, D.M., Paul D Coleman, Jia Guo, Highly sensitive and multiplexed in situ protein profiling with cleavable fluorescent streptavidin. Cold Spring Harbor Laboratory (bioRxiv), 2019.

  6. Piras, I.S., et al., Transcriptome Changes in the Alzheimer's Disease Middle Temporal Gyrus: Importance of RNA Metabolism and Mitochondria-Associated Membrane Genes. J Alzheimers Dis, 2019. 70(3): p. 691-713.

  7. Piras, I.S., et al., Association of AEBP1 and NRN1 RNA expression with Alzheimer's disease and neurofibrillary tangle density in middle temporal gyrus. Brain Res, 2019. 1719: p. 217-224.


2018

  1. Tan, Y., et al., Upregulation of histone deacetylase 2 in laser capture nigral microglia in Parkinson's disease. Neurobiol Aging, 2018. 68: p. 134-141.

  2. Mastroeni, D., et al., Correction: ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 2018. 13(1): p. e0191382.

  3. Mastroeni, D., et al., Laser-captured microglia in the Alzheimer's and Parkinson's brain reveal unique regional expression profiles and suggest a potential role for hepatitis B in the Alzheimer's brain. Neurobiol Aging, 2018. 63: p. 12-21.

  4. Mastroeni, D., et al., Oligomeric amyloid beta preferentially targets neuronal and not glial mitochondrial-encoded mRNAs. Alzheimers Dement, 2018. 14(6): p. 775-786.

  5. Johansson, J.U., et al., Peripheral complement interactions with amyloid beta peptide in Alzheimer's disease: Polymorphisms, structure, and function of complement receptor 1. Alzheimers Dement, 2018.


2017

  1. Mastroeni, D., et al., ANK1 is up-regulated in laser captured microglia in Alzheimer's brain; the importance of addressing cellular heterogeneity. PLoS One, 2017. 12(7): p. e0177814.

  2. Mastroeni, D., et al., Nuclear but not mitochondrial-encoded oxidative phosphorylation genes are altered in aging, mild cognitive impairment, and Alzheimer's disease. Alzheimers Dement, 2017. 13(5): p. 510-519.

  3. Delvaux, E., et al., Multivariate analyses of peripheral blood leukocyte transcripts distinguish Alzheimer's, Parkinson's, control, and those at risk for developing Alzheimer's. Neurobiol Aging, 2017. 58: p. 225-237.

  4. Cummings, J.L. and J. Pillai, Neurodegenerative diseases : unifying principles. 2017, Oxford ; New York: Oxford University Press. xi, 346 pages.

  5. Coleman, P.D. and D. Mastroeni, A call for new approaches to Alzheimer's disease research. Neurobiol Aging, 2017. 57: p. iii-iv.

  6. Brubaker, W.D., et al., Peripheral complement interactions with amyloid beta peptide: Erythrocyte clearance mechanisms. Alzheimers Dement, 2017. 13(12): p. 1397-1409.


2016

  1. Fonseca, M.I., et al., Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function. PLoS One, 2016. 11(2): p. e0149792.

  2. Diego Mastroeni, L., Daniel L.Van den Hove, JenniferNolz, Bart P.F.Rutten, Elaine Delvaux, Paul D.Coleman, Increased 5-hydroxymethylation levels in the sub ventricular zone of the Alzheimer's brain. Neuroepigenetics, 2016. Volume 6: p. 26-31.

  3. Delvaux, E., et al., Novel method to ascertain chromatin accessibility at specific genomic loci from frozen brain homogenates and laser capture microdissected defined cells. Neuroepigenetics, 2016. 6: p. 1-9.


2015

  1. Mastroeni D, Delvaux E, Nolz J, Tan Y, Grover A, Oddo S, Coleman PD. Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease. Neurobiol Aging. 2015 Dec;36(12):3121-9. 2015.08.017. Epub 2015 Sep 10.

  2. Lardenoije R, Iatrou A, Kenisa G, Kompotis K, Steinbusch H, Mastroeni D, Coleman P,. Lemered C, Hof P, van den Hove D, Rutten B (2015). The Epigenetics of Aging and Neurodegeneration. Progress in Neurobiology, Jun 11, 2015

  3. Mastroeni D*, Khdour O*, Arce P, Hecht S, Coleman PD (2015). Novel antioxidants protect mitochondria from the effects of oligomeric amyloid Beta and contribute to the maintenance of epigenome function ACS Chem Neurosci. Apr 15;6(4):588-98. *Joint first authors


2014

  1. Fitzsimons et al. (2014). Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease. Mol Neurodegener. Jun 25;9:25 J Molecular Neurodegeneration. REVIEW

  2. Nural-Guvener HF, Zakharova L, Nimlos J, Popovic S, Mastroeni D, Gaballa MA  (2014) HDAC class I inhibitor, Mocetinostat, reverses cardiac fibrosis in heart failure and diminishes CD90+ cardiac myofibroblast activation. Fibrogenesis Tissue Repair Jul 2;7:10.


2013

  1. Mastroeni D, Chouliaras L, Grover A, Liang WS, Hauns K, et al. (2013) Reduced RAN Expression and Disrupted Transport between Cytoplasm and Nucleus; A Key Event in Alzheimer's Disease Pathophysiology. PLoS One 8: e53349.

  2. Lucin KM, O'Brien CE, Bieri G, Czirr E, Mosher KI, Mastroeni, D. et al. (2013) Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease. Neuron 79: 873-886.

  3. Chouliaras L*, Mastroeni D*, Delvaux E, Grover A, Kenis G, et al. (2013) Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients. Neurobiol Aging 34: 2091-2099. *joint first author


2012

  1. Takahashi R, Giannini C, Sarkaria JN, Schroeder M, Rogers J, Mastroeni D et al. (2012) p53 isoform profiling in glioblastoma and injured brain. Nature Publishing Group, Oncogene.

  2. Synapses and Epigenetics in the Alzheimer’s Brain. Mastroeni D, Berchtold, Coleman P. Society for Neuroscience 2012


2011

  1. Webster J, Reiman EM, Zismann VL, Joshipura KD, Pearson JV, Mastroeni D et al. (2011) Whole genome association analysis shows that ACE is a risk factor for Alzheimer's disease and fails to replicate most candidates from Meta-analysis. Int J Mol Epidemiol Genet 1: 19-30.

  2. Rogers J, Mastroeni D, Grover A, Delvaux E, Whiteside C, et al. (2011) The epigenetics of Alzheimer's disease--additional considerations. Neurobiol Aging 32: 1196-1197.

  3. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, et al. (2011) Epigenetic mechanisms in Alzheimer's disease. Neurobiol Aging 32: 1161-1180.


2010

  1. van den Berge SA, Middeldorp J, Zhang CE, Curtis MA, Leonard BW, Mastroeni, D et al. (2010) Longterm quiescent cells in the aged human subventricular neurogenic system specifically express GFAP-delta. Aging Cell 9: 313-326.

  2. Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Mastreoni D,  et al. (2010) Evidence for an association between KIBRA and late-onset Alzheimer's disease. Neurobiol Aging 31: 901-909.

  3. Zakharova L, Mastroeni D, Mutlu N, Molina M, Goldman S, et al. (2010) Transplantation of cardiac progenitor cell sheet onto infarcted heart promotes cardiogenesis and improves function. Cardiovasc Res 87: 40-49.


2009

  1. Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD (2009) Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One 4: e6617.

  2. Mastroeni D, Grover A, Leonard B, Joyce JN, Coleman PD, et al. (2009) Microglial responses to dopamine in a cell culture model of Parkinson's disease. Neurobiol Aging 30: 1805-1817.

  3. Leonard BW*, Mastroeni D*, Grover A, Liu Q, Yang K, et al. (2009) Subventricular zone neural progenitors from rapid brain autopsies of elderly subjects with and without neurodegenerative disease. J Comp Neurol 515: 269-294. *joint first author


2008

  1. Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, et al. (2008) Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging 31: 2025-2037.

  2. Liang WS, Reiman EM, Valla J, Dunckley T, Beach TG, Mastroeni D,  et al. (2008) Alzheimer's disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons. Proc Natl Acad Sci U S A 105: 4441-4446.

  3. Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, et al. (2008) Neuronal gene expression in non-demented individuals with intermediate Alzheimer's Disease neuropathology. Neurobiol Aging.

  4. Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, et al. (2008) Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set. Physiol Genomics 33: 240-256.


2007

  1. Rogers J, Mastroeni D, Leonard B, Joyce J, Grover A (2007) Neuroinflammation in Alzheimer's disease and Parkinson's disease: are microglia pathogenic in either disorder? Int Rev Neurobiol 82: 235-246.

  2. Reiman EM, Webster JA, Myers AJ, Hardy J, Dunckley T,Mastroeni D, et al. (2007) GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers. Neuron 54: 713-720.

  3. Liang WS, Dunckley T, Beach TG, Grover A, Mastroeni D, et al. (2007) Gene expression profiles in anatomically and functionally distinct regions of the normal aged human brain. Physiol Genomics 28: 311-322.


2006

  1. Rogers J, Li R, Mastroeni D, Grover A, Leonard B, et al. (2006) Peripheral clearance of amyloid beta peptide by complement C3-dependent adherence to erythrocytes. Neurobiol Aging 27: 1733-1739.

  2. Dunckley T, Beach TG, Ramsey KE, Grover A, Mastroeni D, et al. (2006) Gene expression correlates of neurofibrillary tangles in Alzheimer's disease. Neurobiol Aging 27: 1359-1371.


2005

Strohmeyer R, Kovelowski CJ, Mastroeni D, Leonard B, Grover A, et al. (2005) Microglial responses to amyloid beta peptide opsonization and indomethacin treatment. J Neuroinflammation 2: 18.