Associate Research Professor, Biodesign Center for Applied Structural Discovery
Associate Faculty, Biodesign Center for Innovations in Medicine
Dr. Debbie T. Hansen joined ASU in 2012. She has been developing recombinant technologies for over a decade, and her publications have been cited 1400+ times. Dr. Hansen is an Associate Research Professor in the Biodesign Center for Applied Structural Discovery (CASD), directed by Dr. Petra Fromme, and is an Associate Faculty member of the Biodesign Center for Innovations in Medicine (CIM), directed by Dr. Stephen A. Johnston.
Dr. Hansen develops technologies to support the highly challenging atomic-resolution structural determination of integral membrane proteins that are central to disease processes. Her work includes the first report of the efficiency of genetic immunization for generating antibody reagents against membrane proteins. Her co-authored publications include the first reported lipoprotein structure from the tick-borne bacterial pathogen that causes tularemia and development of a recombinant vaccine candidate for AIDS. Additional proteins of structural interest are those critical to the pathogenicities of Lyme disease, African swine fever, Middle East Respiratory Syndrome (MERS), and malaria, and to the patient disorders of pain, allergy, asthma, inflammation, Parkinson’s disease, schizophrenia, cystic fibrosis, fatty liver diseases, cardiovascular diseases, metabolic diseases, glioblastoma, multiple myeloma and mixed lineage leukemia. With CIM, Dr. Hansen also contributed to vaccine development against the African swine fever virus and cancer.
Prior to ASU, Dr. Hansen was a Research Assistant Professor at the Medical University of South Carolina where she co-developed a novel recombinantly-expressed and active form of human telomerase, the RNA-protein complex that is central to cancer and aging. At Yale University, as a Post-doctoral Fellow and an Associate Research Scientist with Dr. Dieter Söll, Dr. Hansen elucidated the origins of the fundamental biochemical pathways of protein translation that are used by the three domains of life. She was also the first to characterize both the recombinant archaeal tRNA amidotransferase protein complexes and the molecular basis of discrimination by the archaeal aspartyl-tRNA synthetases.
Dr. Hansen earned her Ph.D. in Microbiology from the University of Georgia, where she identified novel biochemical pathways and developed genetics tools for diverse microbes. She acquired skills in classical microbial genetics during her B.S. studies in Genetic Biology at Purdue University. Currently at ASU, Dr. Hansen leads collaborations to develop technologies that enable the structural and mechanistic elucidation of membrane proteins, which will provide a basis for the structure-based development of therapeutics. She enjoys extremely challenging research, which requires a highly collaborative and analytical approach