Publications

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In Process

  1. Todd, PW, Ferl, RJ, Bhattacharya, S, Hood, LE, Mills, AL, Nelson, GR., Nickerson, CA, Ott, CM, Pawelczyk, JA, Quinn, RC, Sander, MJ, Venkateswaran, K, Wittenberg, C, Young, LR, 2018. Life Beyond Low Earth Orbit, Report of a Science Working Group. Submitted to the National Aeronautics and Space Administration Human Exploration and Operations Mission Directorate; Space Life and Physical Sciences Division. In Press.

  2. Barrila, J, Sarker S.F., Hansmeier N., Sato K., Rayl N., Ly D., Kosnik C., Yang J., Shimoda C., Bondi M., Landenberger A., Halden R., Davis R., 61. Forsyth R., Ott C.M., Cannon T., and Nickerson C.A. Microgravity Uniquely Alters the Host-Pathogen Interaction between Human Intestinal Cells and Salmonella enterica serovar Typhimurium. Manuscript in preparation.


2018

  1. C.M. Dussik, M. Hockley, A. Grozi., I. Kaneko, L. Zhang, M.S. Sabir, Jin Park, J. Wang, C.A. Nickerson, S.H. Yale, A. Foxx-Orenstein, T. Sandrin1, and P.W. Jurutka, 2017. Gene Expression Profiling and Assessment of Vitamin D and Serotonin Pathway Variations in Patients with Irritable Bowel Syndrome. J Neurogastroenterol Motil. 2018 Jan 30;24(1):96-106. doi: 10.5056/jnm17021.

  2. Barrila, J., Crabbe, A., Yang, J., Franco, K., Nydam, S., Forsyth, R., Davis, R., Gangaraju, S., Ott, C.M., Coyne, C, Bissell, M, and C.A. Nickerson. 2018. Modeling Host-Pathogen Interactions in the Context of the Microenvironment: 3-D Cell Culture Comes of Age (Invited Review). Infect Immun. 2018 Sep 4. pii: IAI.00282-18. doi:10.1128/IAI.00282-18. [Epub ahead of print]


2017

  1. Barrila, J, Yang, J, Crabbé, A., Sarker, S., Liu, Y., Ott, C.M., Nelman-Gonzales, M, Clemett, S.J., Nydam, S.D., Forsyth, R., Davis, R.R., Crucian, B., M., Quiriarte, Roland, K., H., Brenneman, K., Sams, C., Loscher, C., and Nickerson, C.A. 2017. Three-dimensional organotypic co-culture model of intestinal epithelial cells and macrophages to study Salmonella enterica colonization patterns. npj Microgravity. 3, doi:10.1038/s41526-017-0011-2

  2. Crabbé, A., Yulong L, Matthijs, N, de La Fuente-Núñez, C, Davis, R, Phrasavath, S, Ledesma, MA, Sarker, S., Van Houdt, R, Hancock, R.E.W, Coenye, T, and CA. Nickerson. 2017. Pseudomonas aeruginosa co-cultured with three-dimensional lung epithelial cells exerts decreased susceptibility to antimicrobial agents. Sci Reports. 7, doi: 10.1038/srep43321


2016

  1. McConkey, C., Delorme-Axford, E., Kim, K.S., Stolz, D., Nickerson, C.A., Sadovsky, Y, Boyle, J.P., and C.B. Coyne, 2016. A three-dimensional co-culture system recapitulates placental syncytiotrophoblast development and microbial resistance. Science Advances. 2016 Mar 4;2(3):e1501462. doi: 10.1126/sciadv.1501462.

  2. Yang, J, Barrila, J, Roland, K, Ott, C.M., and Nickerson, C.A. 2016. Physiological Fluid Shear Alters the Virulence Potential of Invasive Multidrug Resistant Non-Typhoidal Salmonella Typhimurium D23580. npj Microgravity. 2, 16021; doi:10.1038/npjmgrav.2016.21

  3. C.M. Ott, T. Marshburn, C.A. Nickerson. 2016. Microbiological Research on the International Space Station: An Extreme Environment for Innovative Microbial and Host-Microbe Discoveries. (Invited Review). ASM Microbe. 11:253-261.
    This publication received the cover image illustration for the June issue of ASM Microbe.

  4. Barrila, J, Ott, C.M., LeBlanc, C, Mehta, S.K., Nelman-Gonzales, M, Crabbé, A., Stafford, P., Pierson, D., and Nickerson, C.A. 2016. Spaceflight modulates gene expression in the whole blood of astronauts. npj Microgravity. 2, 16039; doi:10.1038/npjmgrav.2016.39


2015

  1. Crabbé, A. Liu, Y, Sarker, S., Bonenfant, N.R., Barrila, J., Lee, J.L., Weiss, D.J., and C.A. Nickerson. 2015. Improved recellularization of decellularized lung scaffold in low fluid shear suspension. PLoS ONE. 2015 May 11;10(5):e0126846. doi: 10.1371/journal.pone.0126846.

  2. Yang J, Barrila J, Roland KL, Kilbourne J, Ott CM, Forsyth R, and C.A. Nickerson CA. 2015. Characterization of the Invasive, Multidrug Resistant Nontyphoidal Salmonella strain D23580 in a Murine Model of Infection. PLoS Neglected Tropical Diseases. 2015 Jun 19;9(6):e0003839.

  3. Nickerson, C.A. 2015. Introducing npj Microgravity. npj Microgravity. 30 July (2015) doi:10.1038/npjmgrav.2015.6.

  4. C. Drummond, Nickerson, C.A., and C.B. Coyne, 2016. A three-dimensional cell culture model to study enterovirus infection of polarized intestinal epithelial cells. mSphere. 1(1):e00030-15. doi:10.1128/mSphere.00030-15.


2014

  1. Crabbé, A., Ledesma-Barrera, A., and C.A. Nickerson. 2014. Mimicking the host and its microenvironment in vitro for studying mucosal infections by Pseudomonas aeruginosa. Pathog Dis. 2014 Jun;71(1):1-19. doi: 10.1111/2049-632X.12180. Epub 2014 May 23.

  2. A. Soni, L. O’Sullivan, L.N. Quick, C.M. Ott, C.A. Nickerson, J.W. Wilson. 2014. Conservation of the low-shear modeled microgravity response in Enterobacteriaceae. Open Microbiol J. 2014 Jun 13;8:51-8.

  3. Ann R. Kennedy, D.Sc., Brian Crucian, Janice Huff, Sabra Klein, David Moren, Donna Murasko, Cheryl A. Nickerson and Gerald Sonnenfeld. 2014. Effects of Sex and Gender on Adaptation to Space: Immune System. Journal of Women’s Health. Nov 23 (11):956-8.

  4. Bell, J., Nickerson, C., Lopez-Alegria, M., Jones, T., and Pomerantz, William. 2014. Leveraging the Academic-Commercial Partnership for NewSpace. New Space. DOI: 10.1089/space.2014.0009.

  5. Scott-Conner, CEH., Masys, D.R., Bloomfield, S.A., Cook, K.S., Jayaraman, S., Nickerson, CA., Pawelczyk, J.A., Satcher, R.L., Shumaker, R., Stuster, J., Woloschak, G.E., and L.R. Young. 2015. Review of NASA’s Evidence Reports on Human Health Risks: 2014 Letter Report. Institute of Medicine of the National Academies. The National Academies Press, Washington, D.C.


2013

  1. Crabbé, A., Nielsen-Press, S., Woolley, Barrila, J., Buchanan, K., McCracken, J., Ott, M., Nelman-Gonzalez, M., Pierson, D., Wilson, J.W., Stefanyshyn-Piper, H.M., and C.A. Nickerson. Spaceflight enhances aggregation and random budding in Candida albicans. PLoS ONE (2013).

  2. M. Herbst-Kralovetz, A.L. Radtke, M.K. Lay, B.E. Hjelm, A.N. Bolick, S.S. Sarker, R.L. Atmar, D.H. Kingsley, C.J. Arntzen, M.K. Estes, and C.A. Nickerson. 2013. Correlation between lack of norovirus replication and histo-blood group antigen expression in three-dimensional INT-407 intestinal epithelial cell cultures. Emerging Infectious Diseases. Emerg Infect Dis. 2013 March; 19(3): 431–438. Correlation between lack of norovirus replication and histo-blood group antigen expression in three-dimensional INT-407 intestinal epithelial cell cultures. Emerging Infectious Diseases (2013).


2012

  1. De Weirdt, R., Crabbé, A., Roos, S., Vollenweider, S., Lacroix, C., van Pijkeren, J.P., Britton, R.A., Sarker, S., Van de Wiele, T., and C.A. Nickerson. .. Glycerol supplementation enhances Lactobacillus reuteri’s protective effect against colonization by Salmonella enterica serovar Typhimurium in a three-dimensional model of colonic epithelium.. PLoS ONE (2012).

  2. M. Mellata, S. Sarker, C.A. Nickerson, J. Maddux, and R. Curtiss III. New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli.. PLoS ONE (2012).


2011

  1. A. Crabbé, S. Sarker, R.V. Houdt, C.M. Ott, N. Leys, P. Cornelis and C.A. Nickerson. Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model.. Cellular Microbiology (2011).

  2. Castro S.L., Nelman-Gonzalez M., Nickerson C.A., Ott, C.M.. Low fluid shear culture of Staphylococcus aureus induces attachment-independent biofilm formation and represses hfq expression. Environ Microbiol (2011).

  3. Crabbe, A., Schurr, M., Schurr, J., Wilson, J.W., Tsaprailis, R. Bober, J. Devich, A. Ruggles, G, Stefanyshyn-Piper, H.M., and C.A. Nickerson.Hfq is an evolutionarily conserved spaceflight response regulator in Pseudomonas aeruginosa.. Appl. Environ. Microbiol. (2011).

  4. Crabbé, A., Schurr, M., Schurr, J., Wilson, J.W., Tsaprailis, R. Bober, J. Devich, A. Ruggles, G, Stefanyshyn-Piper, H.M., and C.A. Nickerson.Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. Appl. Environ. Microbiol. (2011).

  5. Jennings M.E., Quick L.N., Soni A., Davis R.R., Crosby K, Ott C.M., Nickerson CA., and J.W. Wilson. Characterization of the Salmonella enterica serovar Typhimurium ydcI gene which encodes a conserved DNA binding protein required for full acid stress resistance. J. Bacteriol (2011).

  6. Nickerson, C.A., V.M. Garcia, T.L. Molina, S.L. Castro, C.M. Ott, J. Briggler, A.L. Pitt, J.K. Byram, and M.A. Nickerson. Evaluation of Microorganisms Cultured from Injured and Repressed Tissue Regeneration Sites in Endangered Giant Aquatic Ozark Hellbender Salamanders.PLoS ONE. 2011;6(12):e28906. Epub 2011 Dec 19. (2011).

  7. Ott, C.M., Crabbe, A., Wilson, J.W., Barrila, J.B, and C.A. Nickerson. Effect of spaceflight on microbial gene expression and virulence, in Stress Challenges and Immunity in Space, Ed. Alexander Chouker. 2011.. Springer (2011).


2010

  1. A. Crabbé, S. Sarker, R.V. Houdt, C.M. Ott, N. Leys, P. Cornelis and C.A. Nickerson. Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model. Cellular Microbiology (2010).

  2. Crabbe, A., Pyke, B., Monsierus, P., Van Houdt, R., Nickerson, C.A., Leys, N., and P. Cornelis. Response of Pseudomonas aeruginosa to low shear modeled microgravity involves AlgU regulation. Environ. Microbiol. (2010).

  3. Hjelm, B., A.N. Berta, C.A. Nickerson, C.J. Arntzen, and M.M. Herbst-Kralovetz. Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model. Biology of Reproduction (2010).

  4. L.E. O’Sullivan, C.A. Nickerson, and J.W. Wilson. A series of IncQ-based reporter plasmids for use in a range of Gram negative genera. Journal of Microbiology and Biotechnology May;20(5):871-4. (2010).

  5. Radtke, A., Wilson, J.W., Sarker, S., and C.A. Nickerson. 2010. Radtke, A., Wilson, J.W., Sarker, S., and C.A. Nickerson .. Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells. PLoS ONE (2010).

  6. Skardal, A., S. Sarker, A. Crabbé, C.A. Nickerson, G.D. Prestwich. The Generation of 3-D Tissue Models based on Hyaluronan Hydrogel-Coated Microcarriers within a Rotating Wall Vessel Bioreactor. Biomaterials (2010).

  7. Barrila, J., Radtke, A., Sarker, S., Crabbe, A., Herbst-Kralovetz, M., Ott, C.M., and C. A. Nickerson. Organotypic 3-D cell culture models: Applying the rotating wall vessel to study host-pathogen interactions. Nature Reviews Microbiology (2010).

  8. Sarker, S., Ott, C.M., Barrila, J., and C.A. Nickerson D. iscovery of Spaceflight-regulated Virulence Mechanisms in Salmonella and other Microbial Pathogens: Novel Approaches to Commercial Vaccine Development. Gravitational and Space Biology (2010).


2009

  1. Hjelm, B., A.N. Berta, C.A. Nickerson, C.J. Arntzen, and M.M. Herbst-Kralovetz. Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model. Biology of Reproduction (2009).

  2. La Belle, J.T., Shah, M., Reed, J., Nandakumar, V., Alford, T.L., Wilson, J.W., Nickerson, C.A., and Joshi, L.. A novel sensor for rapid and ultra-low level detection of Salmonella enterica Serovar Typhimurium. Electroanalysis (2009).


2008

  1. J.W. Wilson, C.M. Ott, L. Quick, R. Davis, E. Richter, S. Sarker, A. Crabbe, M. Porter, K. Höner zu Bentrup, R. Ramamurthy, G. Tsaprailis, M. Shah, M. Nelman-Gonzalez, R. Bober, J. Devich, A. Ruggles, J. Barrila, Benjamin, J., C. Goulart, M. Rupert, L. Stodieck, P. Stafford, L. Catella, M.J. Schurr, K. Buchanan, D.L. Pierson, Gorie, D., and C.A. Nickerson. Media ion content inhibits spaceflight-induced increases in microbial virulence. PLoS ONE (2008).

  2. T.A. Myers, C.A. Nickerson, D. Kaushal, C.M. Ott, K. Honer zu Bentrup, R. Ramamurthy, M. Nelman-Gonzales, D.L. Pierson, M.T. Philipp.Closing the Phenotypic Gap between Transformed Neuronal Cell Lines in Culture and Untransformed Neurons. Journal of Neuroscience Methods (2008).

  3. W Cody, J Wilson, D Hendrixson, K McIver, K Hagman, C Ott, Cheryl Nickerson, M Schurr. Skim mild enhances the viability of frozen bacterial stocks. Journal of Microbiol Methods (2008).


2007

  1. E Nauman, C Ott, E Saunders, D Tucker, D Pierson, J Wilson, Cheryl Nickerson. A Novel Quantitative Biosystem to Model Physiological Fluid Shear Stress on Cells. Appl. Environ. Microbiol (2007).

  2. Santander, J.M, Wanda, S.Y., Nickerson, C.A., and R. Curtiss III. Role of RpoS in fine-tuning the synthesis of Vi capsular polysaccharide in Salmonella enterica serotype Typhi. Infect Immun. (2007).


2006

  1. Cheryl Nickerson, E Richter, C Ott. Studying host-pathogen interactions in 3-D: Organotypic models for infectious disease and drug development. Journal of Neuroimmune Pharmacology (2006).

  2. J Santander, S Wanda, Cheryl Nickerson, R Curtiss. Role of RpoS in fine-tuning the synthesis of Vi capsular polysaccharide in Salmonella enterica serotype Typhi (2006).

  3. J Wilson, Cheryl Nickerson. A new experimental approach for studying bacterial genomic island evolution identifies island genes with bacterial host-specific expression patterns. BMC Evol Biol (2006).

  4. K Honer zu Bentrup, S Alexander, N Pellis, K Buchanan, Cheryl Nickerson, R Ramamurthy, M Ott, K Emami, M Nelman-Gonzalez, J Wilson, E Richter, T Goodwin, D Pierson. 3-D organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis.Microbes and Infection (2006).

  5. K Johanson, K Muse, J Freeman, L Stodieck, T Hammond, P Allen, A Gonzalez-Villalobos, J Nesbitt, Cheryl Nickerson, K Honer zu Bentrup, J Wilson, R Ramamurthy, R D'Elia. Haploid deletion strains of Saccharomyces cerevisiae that determine survival during spaceflight. Acta Astronautica (2006).

  6. T Straub, M Abbaszdegan, Cheryl Nickerson, K Höner zu Bentrup, B Mayer, R Bartholomew, C Valdez, C Bruckner-Lea, A Dohnalkova, P Orosz Coghlan, C Gerba. First Report of In Vitro Infection of a 3-Dimensional Organoid Model of Human Small Intestinal Epithelium with Human Noroviruses. Emerging Infectious Diseases (2006).

  7. Nickerson, C.A. and Schurr, M.J. (Eds). Molecular Paradigms of Infectious Disease: A Bacterial Perspective. Kluwer Academic/Plenum Press, New York (2006).

  8. Edited book: Nickerson, Cheryl, Schurr, M J. Molecular Paradigms of Infectious Disease: A Bacterial Perspective. Kluwer Academic/Plenum Press (2006).

  9. Book chapter: C. Coleman, C. Baker, and C.A. Nickerson. The Role of Sigma Factors in Regulating Bacterial Stress Responses and Pathogenesis. Molecular Paradigms of Infectious Disease: A Bacterial Perspective. Kluwer Academic/Plenum Press (2006).

  10. Book chapter: J.W. Wilson and C.A. Nickerson. In-vivo excision, cloning and broad-host-range transfer of large bacterial DNA segments using VEX-Capture. Methods in Molecular Biology. Humana Press (2006).


2005

  1. A Carterson, K Honer zu Bentrup, C Ott, M Clarke, C Vanderburg, K Buchanan, D Pierson, Cheryl Nickerson, M Schurr. A549 lung epithelial cells grown as 3-D aggregates: Alternative tissue culture model for P. aeruginosa pathogenesis. Infect Immun (2005).

  2. H LaMarca, C Ott, K Höner zu Bentrup, C LeBlanc, D Pierson, Cheryl Nickerson, A Nelson, C Morris. A Novel Three-Dimensional Model of Human Placentation for the Study of Human Cytomegalovirus Pathogenesis. Placenta (2005).

  3. J Wilson, Cheryl Nickerson. Cloning of a functional Salmonella SPI-I type III secretion system and development of a method to create mutations and epitope fusions in the cloned genes. Journal of Biotechnology (2005).

  4. R D'Elia, P Allen, K Johanson, Cheryl Nickerson, T Hammond. Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance. Appl Microbiol Biotech (2005).